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《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:

21

期数:

2020年12期

页码:

1778-1782

栏目:

论　著

出版日期:

2020-12-28

文章信息/Info

Title:

Clinical value of controlling nutritional status score in evaluating the prognosis of patients with advanced gastric cancer receiving first-line chemotherapy

作者:

叶维1; 毕延智1; 何光照2; 杨全良1

苏州大学附属常州市肿瘤医院（1.肿瘤内科；2.药剂科），江苏 常州 213000

Author(s):

YEwei * ; BIYan-zhi; HEGuang-zhao; YANGQuan-liang

*DepartmentofOncology, Changzhou CancerHospitalofSoochowUniversity,Changzhou,Jiangsu213000,China Corrspondingauthor: YEWei,E-mail:yeweibaby1986@163.com

关键词:

胃癌; 晚期; 控制营养状态; 预后

Keywords:

Gastric cancer;  Advanced stage;  Controlling nutritional status;  Prognosis

分类号:

R735

DOI:

-

摘要:

目的 探讨控制营养状态（CONUT）评分作为晚期胃癌一线化疗预后标志物的潜在应用。方法 回顾 性分析2013年1月至2018年12月苏州大学附属常州肿瘤医院肿瘤内科收治的123例接受一线化疗晚期胃癌患者 化疗前CONUT评分。根据受试者工作特征曲线（ROC曲线）将123例患者分为低控制营养状态评分（≤2分）组 和高控制营养状态评分（≥3分）组，评估CONUT评分与晚期胃癌患者生存之间的关系。结果 生存分析 （Kaplan-Meier）和秩和检验（log-rank）显示高控制营养状态评分组患者的无进展生存期（PFS）（P=0.013） 和总生存期（OS）显著降低（P=0.01）。进一步的多因素分析表明，CONUT评分是影响患者PFS（HR= 1.575，95%CI1.095~2.267，P=0.014）和OS（HR=1.635，95%CI1.118~2.391，P=0.011）的独立因素。 结论 化疗前CONUT评分与晚期胃癌行一线化疗患者的肿瘤进展及不良预后相关，提示化疗前患者免疫营养 状况检测可以获得较好的预后信息。

Abstract:

Objective To investigate the potential value of controlling nutritional status（CONUT） score as a prognostic biomarker in patients with advanced gastric cancer treated with first-line chemo-therapy. Methods The CONUT scores of123 patients with advanced gastric cancer who received first-line chemotherapy in the Department of Oncology of Changzhou Cancer Hospital Affiliated to So-ochow University from January 2013 to December 2018 were retrospectively evaluated. According to re-ceiver operating characteristic （ROC）curve analysis, 123 patients were divided into two groups: low-CONUT group（≤2 points）and high-CONUT group（≥3 points）, and the relationship between CO-NUT score and survival was evaluated.Results Kaplan-meier analysis and log-rank test showed that progression-free survival （PFS）（P=0.013）and overall survival（OS）were significantly reduced in the high-COONUT group（P=0.01）. Further multivariate analysis showed that CONUT score was an independent factor influencing PFS（HR=1.575, 95%CI 1.095-2.267, P=0.014）and OS（HR= 1.635, 95%CI1.118-2.391,P=0.011）. Conclusion The CONUT score before chemotherapy is asso-ciated with tumor progression and poor prognosis in patients with advanced gastric cancer who received first-line chemotherapy, suggesting that host immunonutritional status detection before chemotherapy can obtain better prognosis information.

参考文献/References:

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备注/Memo

备注/Memo:

基金项目：江苏省常州市卫生计生重大科技中心项目（ZD201611）；江苏省常州市科技计划指导性项目（2017331） 作者简介：叶维，硕士，主治医师，研究方向：消化道肿瘤 通信作者：杨全良，E-mail:55831391@qq.com

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更新日期/Last Update: 2020-12-28