|本期目录/Table of Contents|

[1]张健,陈茜,周立娜,等.支气管哮喘患儿外周血CRP、NLR和PCT水平变化及临床意义[J].慢性病学杂志,2020,21(12):1773-1777.
　ZHANGJian *,CHENXi,ZHOULi-na,et al.Changes and clinical value of neutrophil-to-lymphocyte ratio, platelet hematocrit and C-reaction protein peripheral blood in children with bronchial asthma[J].,2020,21(12):1773-1777.
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支气管哮喘患儿外周血CRP、NLR和PCT水平变化及临床意义

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
21
期数:
2020年12期
页码:
1773-1777
栏目:
论　著
出版日期:
2020-12-28

文章信息/Info

Title:
Changes and clinical value of neutrophil-to-lymphocyte ratio, platelet hematocrit and C-reaction protein peripheral blood in children with bronchial asthma
作者:
张健1; 陈茜1; 周立娜2; 朱旭明1; 崔玉宝1
南京医科大学附属无锡儿童医院（1.检验科；2.呼吸科），江苏 无锡 224003
Author(s):
ZHANGJian * ; CHENXi; ZHOULi-na; ZHUXu-ming; CUIYu-bao
*DepartmentofClinicalLaboratory,WuxiChildren’sHospitalAffiliatedtoNanjingMedicalUniversity, Wuxi,Jiangsu224003,China Correspondingauthor:CUIYu-bao,E-mail:ybcui1975@hotmail.com
关键词:
支气管哮喘; C-反应蛋白; 中性粒细胞-淋巴细胞比值; 血小板压积; 血小板与淋巴细胞比值
Keywords:
Bronchial asthma;  C-reaction protein;  Neutrophil-to-lymphocyte ratio;  Platelet hematocrit;  Platelet-to-lymphocyte ratio
分类号:
R562.25
DOI:
-
摘要:
目的 探讨支气管哮喘（以下简称哮喘）患儿急性发作期外周血常规指标和C-反应蛋白（C-reaction protein，CRP）的变化及其临床价值。方法 选取2019年1月至2020年8月南京医科大学附属无锡儿童医院呼 吸科确诊的哮喘患儿157例作为研究对象，并按其入院病情分为哮喘缓解期组67例和发作期组90例，并选择年 龄、性别等相近的健康儿童59人作为对照组。采用医院电子病历系统收集研究对象的年龄、性别、血常规检查 结果，并计算中性粒细胞与淋巴细胞比值（neutrophil-to-lymphocyte ratio，NLR）、血小板与淋巴细胞比值 （platelet-to-lymphocyte ratio，PLR），后比较三组年龄、性别等一般情况、血细胞计数、CRP、NLR和PLR 等指标，采用多元logistic回归分析筛选哮喘发作的相关因素，并采用受试者工作特征（receiver operating char-acteristic，ROC）曲线评价其对哮喘发作的诊断价值。结果 三组间白细胞计数（white blood cell，WBC）、 淋巴细胞计数（lymphocyte，LY）、中性粒细胞计数（neutrophil，NE）、血小板计数（platelet，PLT）、血小板 压积（platelet hematocrit，PCT）、血小板分布宽度（platelet distribution width，PDW）、CRP、NLR、PLR 等指标比较，差异有统计学意义（P<0.05）；而嗜酸性粒细胞计数（eosinophil, EO）、血红蛋白（hemoglobin， Hb）和红细胞分布宽度（red blood cell distribution width，RDW）比较，差异无统计学差异（P>0.05）；哮喘 发作期患儿与对照组受试者WBC、LY、NE、PLT、PCT、PDW、CRP、NLR、PLR比较，差异有统计学意 义（P<0.05）；哮喘发作期与缓解期LY、NE、PLT、PCT、PDW、CRP、NLR比较，差异有统计学意义（P< 0.05）。Logistic回归分析发现，年龄、PCT与哮喘急性发作呈负相关，是保护因素；而CRP和NLR是哮喘急性 发作的危险因素。ROC曲线发现CRP、NLR和PCT对哮喘急性发作具有诊断价值，其曲线下面积（AUC）分 别为0.826、0.813和0.737。结论 CRP及外周血常规指标NLR、PCT可作为儿童哮喘急性发作的预测评价指 标。
Abstract:
Objective To explore the changes of C-reaction protein（CRP）, neutrophil-to-lympho-cyte ratio（NLR）and platelet hematocrit（PCT）in children with acute exacerbation of bronchial asth-ma.Methods Totally157 patients with bronchial asthma, including 90 acute exacerbation children and 67 non-acute exacerbation children, were enrolled in this study according to the doctors’diagno-sis, and 59 healthy subjects were selected as the control group. The hospital electronic medical recordsystem was used to collect the age, gender, and blood routine examination results of the research sub-jects, and calculate the NLR and the platelet-to-lymphocyte ratio （PLR）. Age, gender and other general conditions, blood cell count, CRP, NLR and PLR and other indicators were compared among the three groups. Multiple logistic regression analysis was used to screen the relevant factors of asthma attacks, and the receiver operating characteristic（ROC）curve was used to evaluates its diagnostic val-ue for acute exacerbation of bronchial asthma. Results The results of white blood cell（WBC）, lymphocyte （LY）, neutrophil（NE）, platelet（PLT）, PCT, platelet distribution width（PDW）, CRP, NLR and PLR were significant different among the three groups（P<0.05）, but eosinophil （EO）, hemoglobin（Hb）, and red blood cell distribution width（RDW）had no significant difference （P>0.05）. Compared with those in the healthy control group, levels of WBC, LY, NE, PLT, PCT, PDW, CRP, NLR and PLR of acute exacerbation group were significantly different（P<0.05）. Compared with the remission group, levels of LY, NE, PLT, PCT, PDW, CRP and NLR of acute exacerbation group were significantly different（P<0.05）. Logistic regression analysis showed that age and PCT were protective factors, but CRP and NLR were risk factors of acute exacerbation of bron-chial asthma. The areas under the curve of CRP, NLR, PCT were 0.826, 0.813 and 0.737, respec-tively, which were of diagnosis value for acute exacerbation of bronchial asthma. Conclusions CRP, NLR and PCT are independent factors of children with acute episodes of bronchial asthma, having greater clinical diagnosis value in acute exacerbation of bronchial asthma.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：江苏省重点研发计划（BE2018627） 作者简介：张健，大学本科，副主任技师，研究方向：临床检验 通信作者：崔玉宝，E-mail: ybcui1975@hotmail.com
更新日期/Last Update: 2020-12-28