|本期目录/Table of Contents|

[1]郭晓飞,邹爱标,王华林.益生元在免疫调节中作用的研究进展[J].慢性病学杂志,2020,21(07):1017-1020.
点击复制

益生元在免疫调节中作用的研究进展

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
21
期数:
2020年07期
页码:
1017-1020
栏目:
综 述
出版日期:
2020-07-28

文章信息/Info

Title:
-
作者:
郭晓飞12邹爱标12王华林13
1.武汉英纽林生物科技有限公司,武汉 430345; 2.清华海峡研究院医学营养(MNT)研究中心,福建 厦门 361006; 3.武汉轻工大学生物与制药工程学院,武汉 430023
Author(s):
-
关键词:
益生元免疫调节作用机理
Keywords:
-
分类号:
R378
DOI:
-
摘要:
益生元作为一种功能性食品成分,在其基本营养价值之外,还可以调节肠道微生物组成及活性,从而在预 防慢性病方面发挥着重要作用。益生元可通过直接刺激免疫系统发挥免疫调节作用,也可通过影响肠道微生物间 接发挥免疫调节作用。本文就益生元在免疫调节方面的研究进展及益生元的免疫调节作用机理进行了综述。
Abstract:
-

参考文献/References:

[1] Gibson GR, Hutkins R, Sanders ME,et al. Expert con-sensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics [J]. Nat Rev Gas-troenterol Hepatol, 2017,14(8):491-502. [2] Shokryazdan P, Jahromi MF, Navidshad B, et al. Effects of prebiotics on immune system and cytokine expression [J]. Med Microbiol Immunol, 2017,206(1):1-9. [3] Dwivedi M, Kumar P, Laddha NC,et al. Induction of regulatory T cells: a role for probiotics and prebiotics to suppress autoimmunity [J]. Autoimm Rev, 2016,15(4):379-392. [4] 高峰,周光宏,韩正康.寡果糖对雏鸡生产性能、免疫功能和内分 泌的影响[J].动物营养学报,2001,17(2):51-55. [5] 胡晓燕,郝选明.补充低聚果糖对递增负荷训练大鼠免疫指标的 影响[J].中国运动医学杂志,2012,31(4):336-340. [6] Li Y, Elmén L, Segota I,et al. Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth [J]. Cell Re-ports,2020,30(6):1753-1766. [7] Knipping K, Orsi A, Boehm G,et al. Microbial and im-mune biomarkers in infants at risk for allergies fed an in-tact cow ’ s milk formula containing specific non- digestible carbohydrates [J]. J Nutr Disorders Ther, 2012,2(3):119. [8] Guigoz Y, Rochat F, Perruisseau-Carrier G,et al. Effects of oligosaccharide on the faecal flora and non-specific im-mune system in elderly people [J]. Nutr Res,2002,22(1-2):13-25.[9] Manhart N, Spittler A, Bergmeister H,et al. Influence of fructooligosaccharides on Peyer’s patch lymphocyte num-bers in healthy and endotoxemic mice [J]. Nutr, 2003,19 (7-8):657-660. [10] Bindels LB, Delzenne NM, Cani PD, et al. Towards a more comprehensive concept for prebiotics [J]. Nat Rev Gastroenterol Hepatol,2015,12(5):303-310. [11] O’Connor EM, O’Herlihy EA, O’Toole PW. Gut micro-biota in older subjects: variation, health consequences and dietary intervention prospects [J]. Proc Nutr Soc, 2014,73 (4):441-451. [12] Oozeer R, Van Limpt K, Ludwig T,et al. Intestinal mi-crobiology in early life: specific prebiotics can have similar functionalities as human- milk oligosaccharides [J]. Am J Clin Nutr,2013,98(2):10-12. [13] Voreades N, Kozil A, Weir TL. Diet and the develop-ment of the human intestinal microbiome [J]. Front Micro-biol,2014,5(1):1-9. [14] 陈亚非,罗琪珊,葛亚中.低聚果糖调节机体免疫功能作用的研究 进展[J].现代食品科技,2005,21(4):83-87. [15] Dou?llou T, Montel MC, Thevenot Sergentet D. Invited review: anti-adhesive properties of bovine oligosaccharides and bovine milk fat globule membrane-associated glycocon-jugates against bacterial food enteropathogens [J]. J Dairy Sci,2017,100(5):3348-3359. [16] Manthey CF, Autran CA, Eckmann L,et al. Human Milk Oligosaccharides Protect Against Enteropathogenic Escherichia coli Attachment In Vitro and EPEC Coloniza-tion in Suckling Mice [J]. J Pediatr Gastroenterol Nutr, 2014,58(2):167-170. [17] Honda K, Littman DR. The microbiota in adaptive im-mune homeostasis and disease [J]. Nature,2016,535(7610): 75-84. [18] Vance RE, Isberg RR, Portnoy DA. Patterns of pathogen-esis: Discrimination of pathogenic and nonpathogenic mi-crobes by the innate immune system [J]. Cell Host Mi-crobe, 2009,6(1):10-21. [19] Schirmer M, Smeekens SP, Vlamakis H, et al. Linking the human gut microbiome to inflammatory cytokine pro-duction capacity [J]. Cell,2016,167(7):1125-1136. [20] Sefik E, Geva-Zatorsky N, Oh S,etal. Individual intesti-nal symbionts induce a distinct population of ROR+ regula-tory T cells [J]. Sci, 2015,349(6251):993-997. [21] Chu H, Khosravi A, Kusumawardhani IP,et al. Gene– microbiota interactions contribute to the pathogenesis of in-flammatory bowel disease [J]. Sci, 2016,352(6289):1116-1120. [22] Donaldson GP, Lee SM, Mazmanian SK. Gut biogeogra-phy of the bacterial microbiota [J]. Nat Rev Microbiol, 2015,14(1):20-32. [23] Bunker JJ, Flynn TM, Koval JC,et al. Innate and adap-tive humoral responses coat distinct commensal bacteria with immunoglobulin a article innate and adaptive humoral responses coat distinct commensal bacteria with immuno-globulin A [J]. Immunity,2015,43(3):1-13. [24] Vinolo MAR, Rodrigues HG, Nachbar RT,et al. Regula-tion of inflammation by short chain fatty acids [J]. Nutr, 2011,3(10):858-876. [25] Suárez-álvarez B, Raneros AB, Ortega F, et al. Epigene-tic modulation of the immune function [J]. Epigenetics, 2013,8(7):694-702. [26] Simeoli R, Mattace Raso G, Pirozzi C, et al. An orally administered butyrate- releasing derivative reduces neutro-phil recruitment and inflammation in dextran sulphate sodi-um-induced murine colitis [J]. Br J Pharmacol, 2017,174 (11):1484-1496. [27] Da Silva MS, Rudkowska I. Dairy nutrients and their ef-fect on inflammatory profile in molecular studies [J]. Mol Nutr Food Res,2015,59(7):1249-1263. [28] Smith PM, Howitt MR, Panikov N,et al. The Microbial Metabolites, Short- Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis [J]. Sci,2013,341(6145):569-573. [29] Wu RY, M??tt?nen P, Napper S,etal. Non-digestible oli-gosaccharides directly regulate host kinome to modulate host inflammatory responses without alterations in the gut microbiota [J]. Microbiome,2017,5(1):135. [30] Huang RL, Deng ZY, Yang CB,et al. Dietary oligochito-san supplementation enhances immune status of broilers [J]. J Sci Food Agricul, 2007,87(1):153-159. [31] Floris F, Sahasrabudhe NM, Marlies E, et al. β2→1-Fructans Modulate the Immune System In Vivo in a Mi-crobiota- Dependent and- Independent Fashion [J]. Fron-tiers Immunol, 2017,8(1):1-14. [32] Seifert S, Watzl B. Inulin and Oligofructose: Review of Experimental Data on Immune Modulation [J]. J Nutr, 2007,137(11Suppl):2563S-2567S. [33] Vogt L, Meyer D, Pullens G,et al. Immunological prop-erties of inulin-type fructans [J]. Crit Rev Food Sci Nutr, 2015,55(3):414-436. [34] Herfel TM, Jacobi SK, Lin X,et al. Polydextrose Enrich-ment of Infant Formula Demonstrates Prebiotic Characteris-tics by Altering Intestinal Microbiota, Organic Acid Con-centrations, and Cytokine Expression in Suckling Piglets [J]. J Nutr, 2011,141(12):2139-2145. [35] Jelena V, Alexandra D, Parveen Y, et al. Modulation of the fecal microflora profile and immune function by a novel trans- galactooligosaccharide mixture (B- GOS) in healthy elderly volunteers [J]. Am J Clin Nutr, 2008,88(5):1438-1446. [36] Capitan- Canadas F, Ortega- Gonzalez M, Guadix E, et al. Prebiotic oligosaccharides directly modulate proinflam-matory cytokine production in monocytes via activation of TLR4 [J]. Mol Nutr Food Res, 2014,58(5):1098-1110. [37] Hansen CHF, Frokiaer H, Christensen AG,et al. Dietary xylooligosaccharide downregulates IFN-γ and the low-grade inflammatory cytokine IL-1β systemically in mice [J]. J Nutr, 2013,143(4):533-540. [38] Zhu J, Zhang Y, Wu G,et al. Inhibitory effects of oligo-chitosan on TNF-α, IL-1β and nitric oxide production in lipopolysaccharide- induced RAW264.7 cells [J]. Mol Med Rep,2015,11(1):729-733. [39] 杨东亮,刘嘉,吴珺,等.肝脏免疫学研究若干进展与挑战[J].实用 肝脏病杂志,2019,22(5):609-612. [40] 熊燕鹃,罗和生.肠道菌群与酒精性肝病[J].胃肠病学和肝病学杂 志,2016,25(9):1062-1065. [41] 孙纪录,贾英民,田洪涛,等.双歧杆菌生长促进因子的研究进展 [J].食品工业科技,2003,24(8):110-112. [42] 刘春雪,陆伟.微生态制剂的免疫作用[J].江西畜牧兽医杂志, 2002,6(1):23-25. [43] Yang X, He F, Zhang Y,etal. Inulin ameliorates alcohol-ic liver disease via suppressing LPS-TLR4-Mψ axis and modulating gut microbiota in mice [J]. Alcohol Clin Exp Res,2019,43(3):411-424.

备注/Memo

备注/Memo:
作者简介:郭晓飞,硕士,研究方向:肠道菌群与代谢健康 通信作者:郭晓飞,E-mail:bayueweiyang2008@163.com
更新日期/Last Update: 2020-07-28