|本期目录/Table of Contents|

[1]史玉泉,戚务芳.抗中性粒细胞胞浆抗体相关血管炎发病机制研究进展[J].慢性病学杂志,2020,21(07):1012-1016.
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抗中性粒细胞胞浆抗体相关血管炎发病机制研究进展

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
21
期数:
2020年07期
页码:
1012-1016
栏目:
综 述
出版日期:
2020-07-28

文章信息/Info

Title:
-
作者:
史玉泉; 戚务芳
天津市第一中心医院风湿免疫科，天津 300192
Author(s):
-
关键词:
血管炎; 抗中性粒细胞胞浆抗体; 发病机制
Keywords:
-
分类号:
R593.9
DOI:
-
摘要:
抗中性粒细胞胞浆抗体（ANCA）相关血管炎（AAV）是一类可累及全身多系统的自身免疫性疾病，以 小血管炎和致病性ANCA存在为特点。包括肉芽肿性多血管炎（GPA）、显微镜下多血管炎（MPA）和嗜酸性 肉芽肿性多血管炎（EGPA），其中GPA主要与蛋白酶3（PR3）-ANCA相关，而MPA和EGPA主要与髓过氧 化物酶（MPO）-ANCA相关。AAV确切病因和发病机制尚未完全阐明，可能在某些遗传背景下由某些环境因 素所诱发。遗传易感性、ANCA、中性粒细胞外捕网途径、补体旁路途径、抗人溶酶体相关膜蛋白2抗体、血小 板以及体液免疫和细胞免疫等多种因素共同导致了这一疾病的发生。本研究就近年来关于AAV发病机制的研究 进展作简要综述。
Abstract:
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参考文献/References:

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备注/Memo

备注/Memo:
作者简介：史玉泉，大学本科，主治医师，研究方向：风湿 免疫 通信作者：史玉泉，E-mail：shi-yuquan@sina.com
更新日期/Last Update: 2020-07-28