«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:

21

期数:

2020年07期

页码:

974-976

栏目:

论　著

出版日期:

2020-07-28

文章信息/Info

Title:

Correlation between miRNA-451expression and prognosis in patients with gastric cancer

作者:

李静

漯河市第二人民医院病理科，河南 漯河 462000

Author(s):

LIJing

Departmentof Pathology, theSecondPeople’sHospitalofLuohe City,Luohe, Henan462000,China Correspondingauthor:LIJing,E-mail:lyuchu@126.com

关键词:

miRNA-451; 胃癌; 预后; 相关性

Keywords:

miRNA-451;  Gastric cancer;  Prognosis;  Correlation

分类号:

R735.2

DOI:

-

摘要:

目的 探讨miRNA-451表达与胃癌患者预后相关性，为临床治疗提供参考。方法 选取漯河市第二人 民医院2015年1月—2017年1月收治的行胃癌根治术的90例患者进行研究，根据患者miRNA-451中位表达水平 分为低表达组（34例）和高表达组（56例）。对mi-RNA表达与胃癌患者临床病理特征进行单因素分析与多因素 分析，并以Kaplan-Meier生存曲线分析癌组织中miRNA-451高、低表达患者生存的差异。结果 不同TNM 分期、不同分化程度及不同转移情况间，miRNA-451的表达差异有统计学意义（P<0.05）。TNM分期（OR= 6.3，95%CI2.9~9.5）及淋巴结转移（OR=7.5，95%CI3.8~11.0）为胃癌组织中miRNA-451表达的独立性 影响因素（P<0.05）。低表达组中位生存时间为（12.79±3.81）个月（95%CI8.33~23.78）；高表达组中位生存 时间为（20.72±5.93）个月（95CI%16.33~32.08），两组相比Log-Rank值为8.53（P=0.003）。结论 miR-NA-451表达与胃癌患者TNM分期及淋巴结转移相关，且与患者预后密切相关。

Abstract:

Objective To investigate the relationship between miRNA-451 expression and prognosis in patients with gastric cancer, and to provide reference for clinical treatment. Methods Ninety patients undergoing radical gastrectomy in the Second People’s Hospital of Luohe City from January 2015 to January 2017 were enrolled. The patients were divided into low expression group（34 cases）and high expression group（56 cases）according to the median expression level of miRNA-451. Univariate analy-sis and multivariate analysis were performed on the expression of mi-RNA and clinicopathological fea-tures of gastric cancer patients. The Kaplan-Meier survival curve was used to analyze the difference of survival time in patients with high and low expression of miRNA-451 in cancer tissues. Results There were significant differences in the expression of miRNA-451 between different TNM stages, dif-ferent degrees of differentiation and different metastasis（P<0.05）. TNM stage（OR=6.3, 95%CI2.9-9.5）and lymph node metastasis（OR=7.5, 95%CI3.8-11.0）were independent factors affecting the ex-pression of miRNA-451 in gastric cancer tissues（P<0.05）. The median survival time of the low ex-pression group was（12.79±3.81）months（95%CI8.33-23.78）; the median survival time of the high expression group was（20.72±5.93）months（95%CI16.33-32.08）. The log-rank value of the two groups was 8.53（P=0.003）. Conclusion The expression of miRNA-451 is associated with TNM stage and lymph node metastasis in patients with gastric cancer, and it is closely related to the progno-sis of patients.

参考文献/References:

[1] Lee YC, Chiang TH, Chou CK, et al. Association Be-tween Helicobacter pylori Eradication and Gastric Cancer Incidence: A Systematic Review and Meta- analysis [J]. Gastroenterol,2016,150(5):1113-1124. [2] Wu C, Zhuang Y, Jiang S,et al. Interaction between Wnt/??-catenin pathway and microRNAs regulates epitheli-al- mesenchymal transition in gastric cancer (Review) [J]. Int J Onco, 2016,48(6):2236-2246. [3] Liu F, Bu Z, Zhao F,et al. Increased T-helper 17 cell differentiation mediated by exosome-mediated microRNA-451 redistribution in gastric cancer infiltrated T cells [J]. Cancer Sci,2018,109(1):65-73. [4] You W, Xu L, Zhang X,et al. High-Throughput Screen-ing Identifies miR- 451 as a Pleiotropic Modulator That Suppresses Gastric Cancer Metastasis [J]. J Lab Autom, 2017,22(2):136. [5] 高永涛,王俊,史建华,等.miR-451与人类肿瘤关系的研究进展 [J].现代生物医学进展,2015,15(9):1769-1771. [6] 任晓峰.miR-451在胃癌中的表达及其调控机制[D].东南大学, 2014. [7] 李莎,白育庭.miR-451与肿瘤的相关性[J].分子诊断与治疗杂 志,2015,7(4):271-275. [8] 黄胜蓝,郑长黎.与胃癌发生相关MicroRNA的研究新进展[J].现 代生物医学进展,2012,12(24):4777-4779. [9] 张茂娜,张弘,张军,等.miR-451a过表达对宫颈癌细胞增殖和凋 亡的影响及其分子机制[J].山西医科大学学报,2017(11):1145-1148. [10] 尤闻道.基于高通量功能筛选的miR-451调控胃癌生物学行为 的机制研究[D].苏州大学,2016.

备注/Memo

备注/Memo:

作者简介：李静，大学本科，主治医师，研究方向：病理诊断 通信作者：李静，E-mail：lyuchu@126.com

常用功能

更新日期/Last Update: 2020-07-28