|本期目录/Table of Contents|

[1]王大强.左西孟旦对急性心力衰竭患者心功能和NT-proBNP、hs-CRP、IL-6、sST2水平的影响[J].慢性病学杂志,2020,21(05):666-669.
　WANGDa-qiang.Effect of levosimendan on heart function and N-terminal probrain natriuretic peptide, high sensitivity C-reactive protein, interleukin-6, soluble suppression of tumourigenicity-2levels in patients with acute heart failure[J].,2020,21(05):666-669.
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左西孟旦对急性心力衰竭患者心功能和NT-proBNP、hs-CRP、IL-6、sST2水平的影响

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
21
期数:
2020年05期
页码:
666-669
栏目:
论　著
出版日期:
2020-05-28

文章信息/Info

Title:
Effect of levosimendan on heart function and N-terminal probrain natriuretic peptide, high sensitivity C-reactive protein, interleukin-6, soluble suppression of tumourigenicity-2levels in patients with acute heart failure
作者:
王大强
南阳医学高等专科学校第一附属医院，河南 南阳 473000
Author(s):
WANGDa-qiang
First AffiliatedHospital of NanyangMedicalCollege，Nanyang,Henan473000，China CorrespondingAuthor：WANG Da-qiang，E-mail:wangdaqiang760525@163.com
关键词:
急性心力衰竭; 左西孟旦; N末端脑钠肽; 高敏C反应蛋白; 白细胞介素6; 可溶性基质裂解素2
Keywords:
Acute heart failure;  Levosimendan;  N-terminal probrain natriuretic peptide;  High sensitivity C-reactive protein;  Interleukin-6;  Soluble suppression of tumourigenicity-2
分类号:
R541
DOI:
-
摘要:
目的 探讨左西孟旦对急性心力衰竭心功能和N-末端脑钠肽（NT-proBNP）、高敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、可溶性基质裂解素2（sST2）水平的影响。方法 选取2018年1至12月南阳医 学高等专科学校第一附属医院收治的100例急性心力衰竭患者，按照随机数字表法分为对照组和研究组，每组 50例。对照组在常规药物治疗基础上给予多巴酚丁胺治疗24h，研究组在常规药物治疗基础上给予左西孟旦治疗 24 h。比较两组治疗前、治疗7 d后的临床疗效、心功能指标、血清NT-proBNP、hs-CRP、IL-6、sST2水 平。结果 治疗后，研究组总有效率高于对照组（P<0.05）；两组治疗后LVEDD、LVESD均低于治疗前， LVEF高于治疗前，差异有统计学意义（P<0.05）。治疗后，研究组LVEDD、LVESD低于对照组，LVEF高于 对照组，差异有统计学意义（P<0.05）；两组治疗后血清NT-proBNP、hs-CRP、IL-6、sST2水平均较治疗前 显著下降（P<0.05），且研究组均明显低于对照组，差异有统计学意义（P<0.05）。两组不良反应总发生率比 较，差异无统计学意义（P>0.05）。结论 左西孟旦对急性心力衰竭患者具有较好的临床效果，能有效改善心功 能，降低血清NT-proBNP、hs-CRP、IL-6、sST2水平。
Abstract:
Objective To explore the effect of levosimendan on heart function and N-terminal probrain natriuretic peptide（NT-proBNP）, high sensitivity C-reactive protein（hs-CRP）, interleukin-6（IL-6）, soluble suppression of tumourigenicity-2（sST2）levels in patients with acute heart failure （AHF）. Methods A total of100 AHF patients treated in First Affiliated Hospital of Nanyang Medical Col-lege from January to December 2018 were selected and randomly divided into control group and study group according to random number table method, each 50 cases. The control group received the dobu-tamine on the basis of the conventional therapy for 24 hours. The study group received the levosimen-dan on the basis of the conventional therapy for 24 hours. The clinical effect and the heart function in-dexes, serum NT-proBNP, IL-6, hs-CRP, sST2 levels were compared before treatment or seven days after treatment. Results The total effective rate of study group was significantly higher than that of control group（P<0.05）. Compared with before treatment, the left ventricular end diastolic diamete （LVEDD）, left ventricular end-systolic diameter（LVESD）levels were decreased, the left ventricular ejection fraction（LVEF）level was increased in the two groups, and there were significantly different-between the two groups（P<0.05）. The serum NT-proBNP, IL-6, hs-CRP, sST2 levels were sig-nificantly decreased in the two groups after treatment compared with before treatment, and which were lower statistically in the study group than in the control group （P<0.05）. There was no significant difference in the total incidence of adverse reactions in the two groups（P>0.05）. Conclusion The levosimendan have good clinical effect and can effectively improve the cardiac function, bring down the serum NT-proBNP, hs-CRP, IL-6, sST2 levels.

参考文献/References:

[1] 胡盛寿,高润霖,刘力生. 《中国心血管病报告》概要[J].中国循环杂 志,2019,34(3):209-220. [2] 中华医学会心血管病学分会心力衰竭学组.中国心力衰竭诊断和 治疗指南2018[J].中华心血管病杂志,2018,46(10):760-789. [3] 刘鹏云,姜雅秋,李鑫.左西孟旦治疗老年失代偿性心力衰竭患者 的疗效[J].中国老年学杂志,2016,36(3):581-582. [4] 张宇辉,卿恩明,张健,等.国产左西孟旦与多巴酚丁胺治疗急性 失代偿性心力衰竭患者血液动力学和疗效对比观察[J].中华医学 杂志,2012,92(8):555-558. [5] 姚瑞,孙同文,杜优优,等.左西孟旦治疗急性心力衰竭的随机对 照临床研究[J].中华急诊医学杂志,2015,24(8):893-896. [6] 《基层医院心力衰竭临床诊疗中B型利钠肽和N末端B型利钠肽 原的应用中国专家建议》专家组.基层医院心力衰竭临床诊疗中 B型利钠肽和N末端B型利钠肽原的应用中国专家建议[J].中华 全科医师杂志,2017,16(3):169-173. [7] 任凯,冯津萍,陈树涛,等.慢性心力衰竭患者血清hs-cTnT、 NT-proBNP、hs-CRP表达水平与心功能相关性研究[J].中国 心血管病研究,2017,15(12):1094-1097. [8] 武星君,官庆妮,杨红萍,等.左西孟旦对急性心力衰竭病人心功 能及血清BNP,IL-6,TNF-α,hs-CRP水平的影响[J].中西医 结合心脑血管病杂,2018,16(3):326-329.[9] 杨峰,徐承义,刘心甜.左西孟旦对急性心肌梗死合并心力衰竭患者 血清sST2水平的影响[J].内科急危重症,2018,24(6):463-466. [10] 崔圆,孙砾贤,张娜,等.血清sST2水平与慢性心力衰竭的相关性 研究[J].承德医学院学报,2016,33(3):197-198. [11] 胡振,张新超,张堃,等.血清可溶性ST2评价老年急性心力衰竭 患者病情与预后的研究[J].中华急诊医学杂志,2016,25(8): 1035-1040. [12] 杨晓慧,王力.左西孟旦对急性失代偿性心力衰竭患者血流动力 学的影响[J].中国急救医学,2015,35(12):59-60.

备注/Memo

备注/Memo:
作者简介：王大强，硕士研究生，副主任医师，研究方向：心力衰竭的发病机制及治疗，心脏电生理，冠心病的发病机制 及治疗 通信作者：王大强，E-mail：wangdaqiang760525@163.com
更新日期/Last Update: 2020-05-28