|本期目录/Table of Contents|

[1]秦英季,杨华.慢性支气管哮喘患者血清HIF-1α、TGF-β1水平变化及意义[J].慢性病学杂志,2020,21(05):662-665.
　QINYing-ji,YANGHua.Changes and significance of serum HIF-1αand TGF-β1levels in patients with chronic bronchial asthma[J].,2020,21(05):662-665.
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慢性支气管哮喘患者血清HIF-1α、TGF-β1水平变化及意义

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
21
期数:
2020年05期
页码:
662-665
栏目:
论　著
出版日期:
2020-05-28

文章信息/Info

Title:
Changes and significance of serum HIF-1αand TGF-β1levels in patients with chronic bronchial asthma
作者:
秦英季; 杨华
山东聊城茌平区人民医院，山东 聊城 252100
Author(s):
QINYing-ji; YANGHua
ShandongLiaochengChipingDistrictPeople’sHospital，Liaocheng,Shandong252100,China Correspondingauthor:QINYing-ji,E-mail:15063581863@163.com
关键词:
慢性支气管哮喘; 缺氧诱导因子-1α; 转化生长因子-β1; 临床分期; 病情严重程度
Keywords:
Chronic bronchial asthma;  Hypoxia-inducible factor-1α;  Transforming growth factor-β1;  Clinical stage;  Severity of illness
分类号:
R569
DOI:
-
摘要:
目的 探讨慢性支气管哮喘患者血清缺氧诱导因子-1α（HIF-1α）、转化生长因子-β1（TGF-β1）水平 变化及意义。方法 选取山东聊城茌平区人民医院2017年2月至2020年2月收治的100例慢性支气管哮喘患者 作为观察组，同期门诊体检的100例健康人员作为对照组，检测并对比两组血清HIF-1α、TGF-β1水平，比较 慢性支气管哮喘患者急性发作期（28例）、慢性持续期（42例）、临床缓解期（30例）血清HIF-1α、TGF-β1水 平，比较轻度（21例）、中度（49例）、重度（30例）患者血清HIF-1α、TGF-β1水平，Pearson相关系数线性 相关分析血清HIF-1α、TGF-β1水平与不同病情严重程度相关性。结果 观察组血清HIF-1α、TGF-β1水平 均显著高于对照组，差异有统计学意义（P<0.05）。急性发作组血清HIF-1α、TGF-β1水平均明显高于慢性持 续组和临床缓解组，慢性持续组血清HIF-1α、TGF-β1水平均明显高于临床缓解组，差异有统计学意义（P< 0.05）。重度组血清HIF-1α、TGF-β1水平均明显高于中度组和轻度组，中度组血清HIF-1α、TGF-β1水平均 明显高于轻度组，差异有统计学意义（P<0.05）。血清HIF-1α、TGF-β1水平与重度、中度、轻度呈正相关 性，r分别为0.847、0.858、0.895、0.834、0.867、0.889，差异有统计学意义（P<0.05）。结论 血清HIF-1α、TGF-β1与慢性支气管炎患者病情呈正相关性，血清HIF-1α、TGF-β1升高，预示患者病情加重。
Abstract:
Objective To explore the changes and significance of serum hypoxia-inducible factor-1α （HIF-1α）and transforming growth factor-β1（TGF-β1）levels in patients with chronic bronchial asth-ma.Methods Totally100 cases of patients with chronic bronchial asthma admitted to Shandong Liao-cheng Chiping District People’s Hospital from February 2017 to February 2020 were selected as the experimental group, and 100 healthy people in the outpatient physical examination during the same peri-od were selected as the control group. The serum HIF-1α and TGF-β1 levels were detected and compared between the two groups. The serum HIF-1α, TGF-β1 levels were compared among the patients with chronic bronchial asthma in acute attack period（28 cases）, chronic duration period（42 cases）, clinical remission period（30 cases）, and which among patients with mild（21 cases）, mod-erate（49 cases）, severe（30 cases）illness were compared. Pearson correlation coefficient linear corre-lation was used to analyze the correlations between the serum HIF-1α, TGF-β1 levels and differ-ent illness severity. Results The levels of serum HIF-1α and TGF-β1 in the experimental group were significantly higher than those in the control group（P<0.05）. The levels of serum HIF-1α and TGF-β1 in the acute attack group were significantly higher than those in the chronic persistent group,the clinical remission group, and which in the chronic persistent group were significantly higher than those in the clinical remission group（P<0.05）. The levels of serum HIF-1α and TGF-β1 in the se-vere group were significantly higher than those in the moderate group and the mild group, and which in the moderate group were significantly higher than those in the mild group （P<0.05）. Serum HIF-1α and TGF-β1 levels were positively correlated with severe, moderate and mild （r was 0.847, 0.858, 0.895, 0.834, 0.867, 0.889, respectively, P<0.05）. Conclusion Serum HIF-1α and TGF-β 1 are positively correlated with illness severity of patients with chronic bronchitis. Higher serum HIF-1α and TGF-β1 indicates that the patient’s illness severity is aggravated.

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备注/Memo

备注/Memo:
作者简介：秦英季，大学本科，主治医师，研究方向：呼吸内科 通信作者：秦英季，E-mail：15063581863@163.com
更新日期/Last Update: 2020-05-28