|本期目录/Table of Contents|

[1]陈敏,单媛媛.卵黏蛋白及其水解肽预防结直肠癌研究进展[J].慢性病学杂志,2019,20(07):957-962.
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卵黏蛋白及其水解肽预防结直肠癌研究进展(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
20
期数:
2019年07期
页码:
957-962
栏目:
卫生健康事业发展70年巡礼
出版日期:
2019-07-28

文章信息/Info

Title:
-
作者:
陈敏; 单媛媛
西北农林科技大学，陕西 杨凌 712100
Author(s):
-
关键词:
卵黏蛋白; 水解肽; 结直肠癌; 抗肿瘤活性; 预防机制
Keywords:
-
分类号:
R15；R735.3
DOI:
-
摘要:
结直肠癌是一种常见的消化道恶性肿瘤，其病因至今仍未明确，饮食习惯、生活方式、疾病、遗传等均是 结直肠癌的危险因素。多数患者在确诊时已经处于晚期，而传统的治疗方法对中晚期患者的治疗效果较差。卵黏 蛋白（Ovomucin）是禽蛋蛋白中一种重要的糖蛋白，卵黏蛋白及其水解肽具有抗肿瘤、抗炎、抗氧化、调节免 疫等多种功能活性，有望为结直肠癌的治疗提供新的策略。本文总结了卵黏蛋白及其水解肽抗肿瘤机制方面的研 究进展以及其预防结直肠癌可能的机制，并对其研究进行了展望，以期为卵黏蛋白及其水解肽在医学和保健方面 的研究和应用提供参考。
Abstract:
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参考文献/References:


[1] Muzny DM, Bainbridge MN, Chang K,et al. Compre-hensive molecular characterization of human colon and rec-tal cancer [J]. Nature, 2012,487(7407):330-337.
[2] 王宁,刘硕,杨雷,张希,等.2018全球癌症统计报告解读[J].肿瘤 综合治疗电子杂志,2019,5(1):87-97.
[3] 张凇源,任健,孙晓宏.卵黏蛋白及其水解物生物活性的研究进展 及展望[J].中国家禽,2018,40(24):45-50.
[4] 徐玉彬,张培建,王超臣.结直肠癌的病因及发病机制的研究进展 [J].中华临床医师杂志(电子版),2015,9(15):2912-2915.
[5] Ahmed FE. Effect of diet, life style, and other environ-mental/chemopreventive factors on colorectal cancer devel-opment, and assessment of the risks [J]. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev,2004,22(2): 91-147.
[6] Greenwald P, Lanza E, Eddy GA,et al. Dietary fiber in the reduction of colon cancer risk [J]. J Am Diet Assoc, 1987,87(9):1178-1188.
[7] 邵红梅,冯瑞,朱红,等.中国人群结直肠癌危险因素的Meta分析 [J].中国慢性病预防与控制,2014,22(2):174-177.
[8] 郑威扬.溃疡性结肠炎相关性结肠癌发病机制初探[D].北京协和 医学院,2009.
[9] Garagnani P, Pirazzini C, Franceschi C. Colorectal cancer microenvironment: among nutrition，gut microbiota，inflam-mation and epigenetics [J]. Curr Pharm Des,2013,19(4): 765-778.
[10] Gochman E, Mahajna J, Shenzer P,et al．The expres-sion of i NOS and nitrotyrosine in colitis and colon cancer in humans [J]. Acta Histochem, 2012,114(8):827-835.
[11] 陆晓娟,李恕军,盛剑秋.结直肠癌与肠道菌群的关系及其作用机 制研究进展[J].人民军医,2019,62(5):461-465,473.
[12] Ohigashi S, Sudo K, Kobayashi D,et al. Changes of the intestinal microbiota, short chain fatty acids, and fecal pH in patients with colorectal cancer [J]. Dig Dis Sci, 2013, 58(6):1717-1726.
[13] 伍威,陈敬地,黄振鹏,等.肠道微生物与结直肠癌发病关系的研 究进展[J].医学综述,2016,22(20):4006-4009.
[14] 郑树.结直肠癌的预防[J].中华肿瘤防治杂志,2006,13(1):1-2.
[15] 套格苏,姜洪伟.结直肠癌常用治疗方法的研究进展[J].世界最新 医学信息文摘,2018,18(55):82-84.
[16] 张梦雅,赵燕,徐明生,等.蛋源性活性组分对炎症性肠病的缓解 作用研究进展[J].食品科学,2018,39(5):321-328.
[17] Burley RW, Vadehra DV. The avian egg: chemistry and biology [M]. New York: Wiley-Interscience Public, 1989: 65-128.
[18] Omana DA, Wang J, Wu J. Ovomucin- a glycoprotein with promising potential [J]. Trends in Food Sci Technol, 2010,21(9):455-463.
[19] Kato A, Wada T, Kobayashi K,et al. Ovomucinfood pro-tein conjugates prepared through the transglutaminase reac-tion [J]. J Agricultural Chemical Society of Japan, 2006,55 (4):1027-1103.
[20] Mine Y. Recent advances in the understanding of egg white protein functionality [J]. Trends in Food Sci Tech-nol,1995,6(7):225-232.
[21] Offengenden M, Fentabil M, Wu J. N- glycosylation of ovomucin from hen egg white [J]. Glycoconjug J, 2011,28 (3):113-123.
[22] Bansil R, Turner BS. Mucin structure, aggregation, physi-ological functions and biomedical applications [J]. Curr Opin Colloid Interface Sci,2006,11(2):164-170.
[23] Omana DA,Wang JP,Wu JP. Ovomuci-a glycoproteinwith promising potential [J]. Trends Food Sci Technol, 2010,21 (9):455-463.
[24] Ohami H, Ohishi H, Yokota T,et al. Cytotoxic effect of sialoglycoprotein derived from avian egg white Ovomucin on the cultured tumor cell [J]. Med Biol,1993,126:19-23.
[25] Yokota T, Ohishi H, Watanabe K. In vitro studies of cy-totoxic effect on sarcoma - 180 cells of β- subunit from egg white Ovomucin [J]. Food Sci Tech, 1999,5:273-278.
[26] 吴静,樊代明.肿瘤血管生成与肿瘤血管抑制治疗[J].世界华人消 化杂志,2001,9(3):316-321.
[27] Oguro T, Watanabe K, Tani H,et al. Morphological ob-servations on antitumour activities of 70kDa fragment in α-subunit from pronase treated Ovomucin in a double grafted tumor system [J]. Food Sci Technol, 2000,6:179-185.
[28] 赵川,李俊萱,刘雪梅,等.肿瘤血管生成机制的研究进展[J].中华 中医药学刊,2017,35(1):130-132.
[29] Takashi Y, Hisanori T, Hifumi O,et al. Interaction be-tween 120 kDa fragment in β- subunit from egg white Ovomucin and Sarcoma-180 cells through basic fibroblast growth factor receptor [J]. Food Sci Technol, 2000,6(4): 275-279.
[30] Tanizaki H, Tanaka H, Iwata H, et al. Activation of macrophages by sulfated glycopeptides in Ovomucin, yolk membrane, and chalazae in chicken eggs [J]. Biosci Bio-technol Biochem, 1997,61:1883-1889.
[31] Watanabe K, Tsuge Y, Shimoyamau M,et al. Antitumor effects of pronase -treated fragments, glycopeptides, from Ovomucin in hen egg white in a double grafted tumor sys-tem [J]. J Agric Food Chem,1998,46:3033-3038
[32] Ebina T,Murata K,Tamura K. Antitumor effect of intratu-moral administration of biological response modifier: Induc-tion of immunosuppressive acidic protein, a type of R1-ac-id glycoprotein, in mice [J]. Jpn J Cancer Res, 1994,85: 93-100.
[33] 周斌,张毅.慢性炎症微环境与肿瘤[J].临床检验杂志,2017,35 (11):840-843.
[34] 姚静,胡容,郭青龙.炎症与癌症的发生发展[J].药物生物技术, 2011,18(04):372-376.
[35] 付丹.卵黏蛋白抑菌活性及其机制的研究[D].华中农业大学, 2015.
[36] 卿莹.幽门螺杆菌相关性胃疾病与结直肠肿瘤的相关性研究[D]. 山东大学,2015.
[37] Kodama Y, Kimura N. Inhibitor of Helicobacter pylori col-onization: US，6235709B1［P］. 2001-05-21.
[38] 王文举,李鸿钧,孙茂盛.NF-κB与持久炎症及肿瘤发生关系[J]. 生命的化学,2007(3):197-199.
[39] Sun X, Chakrabarti S, Fang J, et al. Low- molecular-weight fractions of alcalase hydrolyzed eggovomucinextract exert anti-inflammatory activity in human dermalfibroblasts through the inhibition of tumor necrosis factormediated nu-clear factor κB pathway [J]. Nutrit Res, 2016,36(7):648-657.
[40] Sun X, G?nzle M, Wu J. Identification and Characteriza-tion of Glycopeptides from Egg Protein Ovomucin with Anti- Agglutinating Activity against Porcine K88 Entero-toxigenic Escherichia coli Strains [J]. J Agric Food Chem, 2017,65(4):777-783.
[41] 杨婕琳,赵东强.消化系统恶性肿瘤与氧化应激关系的研究进展 [J].胃肠病学,2015,20(2):113-115.
[42] 邬容,王东.氧化应激与结直肠癌的关系[J].西南军医,2015,17 (2):186-188.
[43] 云图娅,苏秀兰.抗氧化肽通过抗氧化作用抗肿瘤研究进展[J].世 界最新医学信息文摘,2018,18(68):71-73.
[44] Chang OK, Ha GE, Han GS, et al. Novel antioxidant Peptide derived from the ultrafiltrate of ovomucin hydroly-sate [J]. J Agric Food Chem, 2013,61(30):7294-7300.
[45] Abeyrathne ED, Lee HY, Jo C,et al. Enzymatic hydroly-sis of ovomucin and the functional and structural character-istics of peptides in the hydrolysates [J]. Food Chemistry, 2016,192:107-113.
[46] 陈盈盈,李睿岩,陈欢,等.靶向肠道固有免疫系统和适应性免疫 系统的药物开发与应用[J].中国药科大学学报,2016,47(4):388-396.
[47] 张嘉宁,汪淑晶.唾液酸生物学与人类健康和疾病[J].生命科学, 2011,23(7):678-684.
[48] 陆晓娟,李恕军,盛剑秋.结直肠癌与肠道菌群的关系及其作用机 制研究进展[J].人民军医,2019,62(5):461-465,473.
[49] 王纯,陈东风,魏艳玲.肠道菌群对结直肠癌发生、发展和诊疗影 响的研究进展[J].胃肠病学,2019,24(1):62-64.
[50] Sun X, G?nzle M, Field CJ, et al. Effect of proteolysis on the sialic acid content and bifidogenic activity of ovomu-cin hydrolysates [J]. Food Chem, 2016,212:78-86.
[51] 王淑媛,宋慧.鸡肠道菌群和短链脂肪酸相互关系的研究进展[J]. 中国微生态学杂志,2018,30(7):849-852.

备注/Memo

备注/Memo:
作者简介：陈敏，本科生，研究方向：食品质量与安全 通信作者：单媛媛，E-mail：shanyy2013@163.com
更新日期/Last Update: 2019-07-28