|本期目录/Table of Contents|

[1]吴霞,石帅,陈庆云,等.丹参注射液联合雷公藤多苷片对过敏性紫癜肾炎患儿尿IGF-1、TGF-β1及凝血机制的影响[J].慢性病学杂志,2019,20(06):823-826.
　WUXia,SHIShuai,CHENQing-yun,et al.Effect of Danshen injections combined with tripterygium glycosides on urinary IGF-1, TGF-β1and coagulation mechanism in children with Henoch-Schonlein purpura nephritis[J].,2019,20(06):823-826.
点击复制

丹参注射液联合雷公藤多苷片对过敏性紫癜肾炎患儿尿IGF-1、TGF-β1及凝血机制的影响(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
20
期数:
2019年06期
页码:
823-826
栏目:
论　著
出版日期:
2019-06-28

文章信息/Info

Title:
Effect of Danshen injections combined with tripterygium glycosides on urinary IGF-1, TGF-β1and coagulation mechanism in children with Henoch-Schonlein purpura nephritis
作者:
吴霞; 石帅; 陈庆云; 焦林娟
南阳市第二人民医院肾病风湿科，河南 南阳 473012
Author(s):
WUXia; SHIShuai; CHENQing-yun; JIAOLin-juan
TheSecondPeople’s HospitalofNanyang,Nanyang,Henan473012,China Correspondingauthor:CHENQing-yun,E-mail:jamsgg@yeah.net
关键词:
丹参注射液; 雷公藤多苷片; 过敏性紫癜肾炎; 胰岛素样生长因子1; 转化生长因子-β; 凝血机制
Keywords:
Danshen injections;  Tripterygium glycosides;  Henoch-Schonlein purpura nephritis;  Insulin-like growth factor 1;  Transforming growth factor-β;  Coagulation mechanism
分类号:
R272
DOI:
-
摘要:
目的 探讨丹参注射液联合雷公藤多苷片对过敏性紫癜肾炎的治疗效果及其机制。方法 选取南阳市第 二人民医院2014年2月—2016年2月收治的120例过敏性紫癜肾炎患儿，按随机数字表法分为研究组和对照组， 每组60例。对照组予以常规治疗，研究组在常规治疗基础上给予丹参注射液联合雷公藤多苷片治疗，治疗4周 为1个疗程，两组均连续治疗3个疗程。采血测定凝血功能、炎症因子及免疫功能等指标，收集尿液测定单核细 胞趋化蛋白-1（MCP-1）、胰岛素样生长因子1（IGF-1）、转化生长因子-β（TGF-β）水平，记录不良反应状 况。结果 与对照组比较，治疗后研究组D-二聚体（D-D）、纤维蛋白原（FIB）、血小板（PLT）水平较低， 凝血酶原时间（PT）水平较高，肿瘤坏死因子（TNF-α）、白细胞介素-6（IL-6）、白细胞介素8（IL-8）及白 细胞介素13（IL-13）水平较低，CD3 +、CD3 + CD4 +含量较高，CD19 +含量较低，MCP-1、TGF-β1及IGF-1 水平较低，差异有统计学意义（P<0.05）；两组患儿均获得随访，两组不良反应发生率分别为20.00%、26.67%， 差异无统计学意义（P>0.05）。结论 丹参注射液联合雷公藤多苷片治疗过敏性紫癜肾炎患儿，降低IGF-1、 TGF-β1水平，改善凝血机制，安全性高。
Abstract:
Objective To investigate the effect of Danshen injections combined with tripterygium glyco-sides in the treatment of children with Henoch-Schonlein purpura nephritis and its mechanism. Methods A total of120 children with Henoch-Schonlein purpura nephritis were selected and randomly divided into 2 groups, 60 cases per group. The control group received routine treatment, and the observation group received treatment of Danshen injection combined with tripterygium glycosides on the base of routine treatment, 4 weeks for1 course and all for 3 courses. Blood determination coagulation func-tion, inflammatory factors and immune function index were determined and MCP-1 and TGF-β1, IGF-1 content in urine were compared and adverse condition was recorded after the treatment. Results Compared with the control group after the treatment, levels of D-D, FIB, PLT in the observation group were decreased, PT was increased, TNF-α, IL-6, IL-8 and IL-13 were decreased, contents of CD3 + and CD3 + CD4 + were increased, content of CD19 + was decreased, levels of MCP-1, TGF-β 1, IGF-1 were decreased, the differences were statistically significant（P<0.05）. All patients in two groups were followed up and there was no significant difference in adverse rate data between them（10.00% vs.6.67%,P>0.05）. Conclusion Danshen injections combined with tripterygium glyco-sides was effective with high safety forchildren with Henoch-Schonlein purpura nephritis, and it can re-duce the content of IGF-1, TGF-β1 and improve the coagulation mechanism.

参考文献/References:


[1] Gong J, Qian X, Hu F,et al. Association ofβ-fibrinogen gene polymorphism and plasma fibrinogen and allergic pur-pura nephritis [J]. Int J Clin Exp Med, 2015,8(7):11322-11326.
[2] Kuwabara T, Ohnishi T, Kakuta Y, et al. Successful treatment of allergic purpura nephritis associated with thrombotic microangiopathy using plasma exchange: a case report [J]. Nihon Jinzo Gakkai Shi, 2004,46(8):815-821.
[3] 徐锦.丹参注射液对过敏性紫癜患儿保护作用的研究[J].新乡医 学院学报,2013,30(9):744-746.
[4] 侯玲,杜悦,吴玉斌.雷公藤多苷治疗儿童过敏性紫癜肾炎的疗效 分析[J].中国小儿急救医学,2011,18(3):275-276.
[5] 中华医学会儿科学分会肾脏病学组.紫癜性肾炎的诊断与治疗(草 案)[J].中国实用儿科杂志,2003,18(3):189-189.
[6] 中华中医药学会发布.中医儿科常见病诊疗指南[M].北京:中国中 医药出版社,2012.
[7] 中华医学会儿科学分会免疫学组.儿童过敏性紫癜循证诊治建议 [J].中华儿科杂志,2013,51(7):502-507.
[8] 中华医学会儿科学分会肾脏病学组.儿童常见肾脏疾病诊治循证 指南(二):紫癜性肾炎的诊治循证指南(试行)[J].中华儿科杂志, 2009,47(12):911-913.
[9] 赵建辉.过敏性紫癜肾炎诊治进展[J].中国中西医结合肾病杂志, 2013,14(4):603-605.
[10] 张鑫,武祯,李航.雷公藤多甙片药理学研究进展及临床应用[J]. 临床药物治疗杂志,2014,12(4):8-13.
[11] 王桂蓉.丹参注射液的药理作用与临床研究进展[J].现代医药卫 生,2006,22(10):1473-1474.
[12] 朱廷富,褚祝飞,李精华.雷公藤多苷联合丹参注射液对过敏性紫 癜性肾炎患儿凝血机制的影响[J].中国中药杂志,2016,41(11): 2162-2167.
[13] 王俊宏,丁樱,任献青,等.雷公藤多苷加辨证中药对小儿过敏性 紫癜性肾炎凝血机制的影响[J].中医杂志,2012,53(3):212-214.
[14] 董宠凯,马丙祥,王怡珍.丹参注射液改善血流变学及凝血功能的 实验研究进展[J].河南中医,2016,60(2):355-357.
[15] 刘剑锋,胡擎鹏,冯伟,等.过敏性紫癜患儿尿中单核细胞趋化蛋 白-1及转化生长因子-β1检测的意义[J].广东医学,2011,32(24): 3248-3250.
[16] 于少飞,冯万禹,柴少卿,等.血和尿胰岛素样生长因子-1水平与 过敏性紫癜患儿肾损害的关系[J].临床和实验医学杂志,2015,14 (20):1676-1679.
[17] 王树祥,马洪波,路群.雷公藤多甙治疗儿童过敏性紫癜性肾炎的 临床疗效及其对Th1、Th2细胞因子的影响[J].山东医药,2009, 49(21):67-68.
[18] 陈智能,宋新志,曹喻灵.丹参注射液对过敏性紫癜患儿TNF-α、 IL-6、IL-8的影响[J].临床医学工程,2009,16(12):89-90.
[19] 翟昌纯,覃险峰,贺晓燕,等.丹参注射联合西咪替丁治疗小儿过 敏性紫癜临床效果及对免疫功能的影响[J].临床与病理杂志, 2016,60(4):463-467.

备注/Memo

备注/Memo:
作者简介：吴霞，硕士，主治医师，研究方向：主要从事肾病风湿疾病研究 通信作者：陈庆云，E-mail：jamsgg@yeah.net
更新日期/Last Update: 2019-06-28