|本期目录/Table of Contents|

[1]许真真.不同剂量米力农治疗老年慢性心力衰竭合并肺动脉高压的临床效果[J].慢性病学杂志,2019,20(06):820-822.
　XUZhen-zhen.Clinical effect of different doses of milrinone in the treatment of elderly patients with chronic heart failure complicated with pulmonary hypertension[J].,2019,20(06):820-822.
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不同剂量米力农治疗老年慢性心力衰竭合并肺动脉高压的临床效果(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
20
期数:
2019年06期
页码:
820-822
栏目:
论　著
出版日期:
2019-06-28

文章信息/Info

Title:
Clinical effect of different doses of milrinone in the treatment of elderly patients with chronic heart failure complicated with pulmonary hypertension
作者:
许真真
高唐县人民医院心内科，山东 聊城 252800
Author(s):
XUZhen-zhen
Departmentof Cardiology, Gaotang CountyPeople's Hospital,Liaocheng,Shandong252800,China
关键词:
米力农; 慢性左心力衰竭; 肺动脉高压
Keywords:
Milrinone;  Chronic left heart failure;  Pulmonary hypertension
分类号:
R271.9
DOI:
-
摘要:
目的 探讨不同剂量米力农治疗老年慢性左心力衰竭合并肺动脉高压的临床效果，为临床治疗提供参 考。方法 选取2017年10月—2018年10月高唐县人民医院收治的92例老年慢性左心力衰竭合并肺动脉高压患 者，随机分为对照组和观察组，各46例。患者入院后均接受常规基础治疗，在此基础上，对照组给予0.5 μg/kg 米力农微量24h泵入治疗，观察组给予0.8 μg/kg米力农微量24h泵入治疗。治疗前后，观察并比较两组心肺功 能情况6分钟步行试验距离（6MWT）、Borg呼吸困难指数、肺动脉收缩压（SPAP）、脑钠肽（BNP）、超敏C 反应蛋白（hs-CRP）水平；观察并比较两组治疗期间不良反应发生情况。结果 治疗前，两组6MWT、Borg 呼吸困难指数及SPAP水平比较，差异均无统计学意义（P>0.05）；治疗后，观察组6MWT高于本组治疗前和 同期对照组，Borg呼吸困难指数及SPAP水平均低于本组治疗前和同期对照组，差异有统计学意义（P<0.05）。 治疗前，两组NT-proBNP、hs-CRP指标水平比较，差异均无统计学意义（P>0.05）；治疗后，观察组NT-proBNP、hs-CRP指标水平均低于本组治疗前和同期对照组，差异有统计学意义（P<0.05）。观察组不良反应总 发生率为8.71%，与对照组的6.52%比较，差异无统计学意义（P>0.05）。结论 米力农治疗老年慢性左心力衰 竭合并肺动脉高压安全有效，其中应用0.8 μg/kg的高剂量临床效果更佳。
Abstract:
Objective To investigate the clinical effect of different doses of milrinone in the treatment of elderly patients with chronic left heart failure complicated with pulmonary hypertension. Methods From October 2017 to October 2018, 92 elderly patients with chronic left heart failure complicated with pulmonary hypertension were randomly divided into two groups,46 cases in each group, All the patients were treated with routine basic treatment. On this basis, the control group was treated with 0.5 μg/kg milrinone, and the observation group was treated with 0.8 μg/kg milrinone, all by micro-pump for 24 hours. Before and after treatment, the distance of 6-minute walking test（6MWT）, Borg dyspnea index, the level of pulmonary artery pressure（SPAP）, brain natriuretic peptide（NT-proBNP）, hypersensitive C-reactive protein（hs-CRP）of the two groups were observed and com-pared. The occurrence of adverse reactions during treatment was observed and compared between the two groups. Results Before treatment, there were no signifcant differences in6MWT, Borg dyspnea index and SPAP between the two groups （all P>0.05）. After treatment, 6MWT, Borg dyspnea in-dex and SPAPwere improved significantly in the two groups, and they were better in the observation group than those in the control group（P<0.05）. Before treatment, there were no signifcant differenc-es in the levels of NT-proBNP and hs-CRP between the two groups（all P>0.05）. After treatment,the levels of NT-proBNP and hs-CRP were significantly diseased in both groups, and the levels of the observation group were lower than those of the control group（P<0.05）. There was no difference in the incidence of adverse reactions between the control group and the observation group （6.52% vs. 8.71%,P<0.05）.Conclusion Milrinone is safe and effective in the treatment of elderly patients with chronic left heart failure complicated with pulmonary hypertension. The high dose of 0.8 μg/kg has bet-ter clinical effect.

参考文献/References:


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备注/Memo

备注/Memo:
作者简介：许真真，硕士，主治医师，研究方向：主要从事心内科的临床工作 通信作者：许真真，Email：xuzz198206@163.com
更新日期/Last Update: 2019-06-28