|本期目录/Table of Contents|

[1]郭丹.缺血性脑血管病患者脑动脉狭窄影响因素[J].慢性病学杂志,2019,20(04):504-507.
　GUODan.Influence factors of cerebral artery stenosis in patients with ischemic cerebrovascular disease[J].,2019,20(04):504-507.
点击复制

缺血性脑血管病患者脑动脉狭窄影响因素(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
20
期数:
2019年04期
页码:
504-507
栏目:
论　著
出版日期:
2019-05-16

文章信息/Info

Title:
Influence factors of cerebral artery stenosis in patients with ischemic cerebrovascular disease
作者:
郭丹
北京市丰台中西医结合医院，北京 100072
Author(s):
GUODan
Beijing FengtaiHospital of IntegratedTraditional Chinese andWesternMedicine,Beijing100072,China Correspondingauthor:GUODan,E-mail：2473913981@qq.com
关键词:
缺血性脑血管病; 脑动脉狭窄; 头颅磁共振血管成像; 多因素分析
Keywords:
Ischemic cerebrovascular disease;  Cerebral artery stenosis;  Cranial magnetic resonance inag-ing and angiography;  Multivariate analysis
分类号:
R743
DOI:
-
摘要:
目的 了解缺血性脑血管病脑动脉狭窄的特点，探讨影响其狭窄的危险因素。方法 选取2016年1月— 2018年10月北京市丰台中西医结合医院神经内科经头颅磁共振血管成像检查的缺血性脑血管病患者186例作为研 究对象，按照其有无发生脑动脉狭窄分为两组，收集研究对象的一般人口学资料，检测所有患者的血压、血脂、 血糖、血尿酸等临床指标。结果 两组年龄、高血压、糖尿病、糖化血红蛋白、甘油三酯（TG）、总胆固醇 （TC）、低密度脂蛋白胆固醇（LDL-C）、尿酸（UA）和血清同型半胱氨酸（Hcy）比较，差异均有统计学意义 （P<0.05）；100例缺血性脑血管病脑动脉狭窄组患者分为30例轻度狭窄、38例中度狭窄和32例重度狭窄三组， 年龄越高，高血压和糖尿病所占比例越大，脑动脉狭窄程度增加；LDL-C、UA和Hcy水平升高，脑动脉狭窄程 度越重（P<0.05）。经多因素logistic回归分析结果显示，年龄、高血压、糖尿病、LDL-C和Hcy是缺血性脑血 管病脑动脉狭窄的危险因素。结论 高年龄、高血压、糖尿病和LDL-C及Hcy是引起缺血性脑血管病发生脑 动脉狭窄的危险因素。
Abstract:
Objective To understand the characteristics of cerebral artery stenosis in ischemic cerebro-vascular disease and to explore the risk factors affecting cerebral artery stenosis. Methods Totally 186 patients with ischemic cerebrovascular disease examined by cranial magnetic resonance angiography （MRA）from January 2016 to October 2018 in the Department of Neurology of Fengtai Hospital of Traditional Chinese and Western Medicine were enrolled and were divided into two groups according to whether there was cerebral artery stenosis or not. The general demographic data of the subjects were collected and the clinical indexes such as blood pressure, blood lipid, blood sugar and blood uric acid were measured.Results There were significant differences in age, hypertension, diabetes mellitus, glycated hemoglobin, triglyceride（TG）, total cholesterol（TC）, low density lipoprotein cholesterol （LDL-C）, uric acid（UA）and serum homocysteine（Hcy）between the two groups（all P<0.05）. Totally100 patients with cerebral artery stenosis of ischemic cerebrovascular disease were divided into 30 cases of mild stenosis and 38 cases of cerebral artery stenosis and 32 cases of severe stenosis group. The higher the age was, the higher the proportion of hypertension and diabetes had, the higher the degree of cerebral artery stenosis was. With the increase of the levels of LDL-C, UA and Hcy, the degree of cerebral artery stenosis were more severe （all P<0.05）. Multivariate logistic regression analysis showed that age, hypertension, diabetes, LDL-C and Hcy were risk factors for cerebral ar-tery stenosis in ischemic cerebrovascular disease. Conclusions These factors such as elder age, hyper-tension, diabetes mellitus, LDL-C and Hcy are risk factors for cerebral artery stenosis in ischemic cerebrovascular disease.

参考文献/References:


[1] 余传庆,张梅,薛敏,等.缺血性脑血管病患者脑动脉狭窄的分布 特征及其危险因素分析[J],神经病学与神经康复学杂志,2010,7 (3):142-145.
[2] 娄华.慢性缺血性脑血管病与脑动脉硬化性狭窄相关性及高危因 素分析[D].郑州：河南大学,2011:20-35.
[3] 魏薇.急性脑梗死患者脑动脉狭窄的分布及危险因素分析[D].蚌 埠:蚌埠医学院,2014:12-28.
[4] 吴倩.100例脑动脉闭塞或重度狭窄的分布特征及危险因素分析 [D].石家庄：河北医科大学,2013:11-35.
[5] 陈岚,瞿浩,李玫.急性缺血性脑血管病患者脑动脉粥样硬化性狭 窄的分布及相关因素分析[J].贵州省第六届中西医结合神经科学 术年会论文汇编.2012,36(7):602-605.
[6] 黄治飞,朱幼玲,朱双根,等.缺血性脑卒中患者颅内外脑动脉狭 窄的分布及其危险因素分析[J].中华老年心血管病杂志,2015,17 (15):451-454.
[7] 缺血性脑血管病患者脑动脉狭窄特点及相关危险因素分析[J].神 经损伤与功能重建,2011,6(5):343-345.
[8] 黄献,宋治,郑文.短暂性脑缺血发作患者脑动脉狭窄及与脑血管 危险因素的研究[J].实用心脑肺血管杂志,2010,18(9):123-125.
[9] 魏薇,胡中文,曾庆宏,等.急性缺血性卒中患者的脑动脉狭窄分 布和危险因素[J].国际脑血管病杂志,2014,22(5):528-534.
[10] Tsantilas P, Kuhnl A, Kallmayer M,et al. Stroke risk in the early period symptoms:a systematic review [J]. J Car-diovasc Surg(Torino),2015,56(6):845-852.
[11] Chiavaroli L, de Souza RJ, Ha V,et al. Effect of fructose on established lipid targets:A systematic reveiew and meta-Analysis of controlled feeding trials [J]. Am Heart Assoc, 2015,4(9):695-700.
[12] He Y, Li Y, Chen Y,et al. Homocysteine level and risk of different stroke types:a meta-analysis of prospective ob-servational studies [J]. Nutr Metab Cardiovasc Dis Cardio-vasc Dis,2014,24(11):1158-1165.
[13] Jeong SK, SeoJY, Cho YI. Homocysteine and intemal ca-rotid artery occlusion in ischemic in ischemic stroke [J]. Atheroscler Thromd,2010,17(9):963-969.
[14] 陈长春,黎西,孙中武.缺血性脑血管病患者脑动脉狭窄严重程度 的影响因素[J].中华疾病控制杂志,2016,20(5):530-532.

备注/Memo

备注/Memo:
作者简介：郭丹，硕士研究生，主治医师，研究方向：脑血管方向 通信作者：郭丹，E-mail：2473913981@qq.com
更新日期/Last Update: 2019-04-28