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《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:

20

期数:

2019年04期

页码:

486-488

栏目:

论　著

出版日期:

2019-05-16

文章信息/Info

Title:

Efficacy of intensive treatment with insulin pump in Mongolian patients with newly diagnosed type2diabetes

作者:

许英; 杨敏

通辽市医院内分泌科，内蒙古 通辽 028000

Author(s):

XUYing; YANGMin

Departmentof Endocrinology,Tongliao Hospital,Tongliao, InnerMongolian028000,China Correspondingauthor:XUYing,E-mail:tlxuying@126.com

关键词:

2型糖尿病; 初诊; 强化治疗; 蒙古族

Keywords:

Type2 diabetes mellitus;  Newly diagnosed;  Intensive therapy;  Mongolian nationality

分类号:

R587.1

DOI:

-

摘要:

目的 探讨蒙古族初诊2型糖尿病（T2DM）患者经胰岛素泵强化治疗3年后血糖控制情况以及临床缓解 率，旨在为开展蒙古族患者糖尿病的预防和控制提供依据。方法 选取通辽市医院2014年8月—2015年12月收 治的初诊T2DM经胰岛素泵强化治疗达到临床缓解期的患者240例为研究对象，分为观察组（蒙古族患者）和对 照组（汉族患者），每组120例。比较两组患者治疗后的空腹血糖（FPG）、餐后2h血糖（2hPG）、糖化血红蛋白 （HbA1c）、胰岛β细胞指数（Homa-β）、胰岛素抵抗指数（Homa-IR）及临床缓解率。结果 两组患者治疗3年 后的FPG、2hPG、HbA1c、Homa-β和Homa-IR均优于治疗前，差异有统计学意义（P<0.05）；观察组治疗3年 后的FPG、2hPG和HbA1c高于对照组，差异均有统计学意义（P<0.05）。观察组的1年临床缓解率（28.33%）低 于对照组（56.67%），差异有统计学意义（P<0.05）；观察组的3年临床缓解率（8.33%）低于对照组 （17.91%），差异有统计学意义（P<0.05）；两组的2年临床缓解率比较，差异无统计学意义（P>0.05）。结论 蒙古族初诊T2DM患者经胰岛素泵强化治疗后，血糖水平控制良好，但是，蒙古族患者血糖控制情况较汉族患 者差，蒙古族患者的1年、3年临床缓解率低于汉族患者的临床缓解率。

Abstract:

Objective To investigate the blood glucose control status and clinical remission rate of newly diagnosed type 2 diabetes（T2DM）patients of Mongolian after intensive treatment with insulin pump for 3 years, and in order to provide evidence for the prevention and control of diabetes mellitus in Inner Mongolian patients. Methods Totally240 cases of newly diagnosed T2DM patients admitted to Tongliao Hospital from August 2014 and December 2015 were selected as study subjects,and they were in the clinical remission stage after intensive treatment with insulin pump. The subjects were di-vided into the observation group（Mongolian nationality）and the control group（Han nationality）, each 120 cases. These indicators such as fasting plasma glucose（FPG）, 2-h postload plasma glucose （2hPG）, hemoglobin A1c （HbA1c）, homeostatic model assessmen-β（Homa-β）and homeostatic model assessmen-insulin resistance（Homa-IR）, and three-year clinical remission rates were com-pared between the two groups. Results These indicators such as FPG,2hPG, HbA1c, Homa-β and Homa-IR of the two groups after 3 years of treatment were better than those before treatment, and the differences were statistically significant（all P<0.05）. Levels of FPG, 2hPG and HbA1c inthe observation group were higher than those in the control group after 3 years of treatment, and the difference was statistically significant （all P<0.05）. The one-year clinical remission rate and the three-year clinical remission rate in observation were significantly lower than those in the control group （one-year clinical remission rate: 28.33% vs.8.33%; three-year clinical remission rate:56.67% vs. 17.91%）. The two-year clinical remission rate was not significantly different in the two groups （P> 0.05）. Conclusions After intensive treatment with insulin pump, the blood glucose level of newly diagnosed T2DM patients of Mongolian is well controlled. But the blood glucose control status of the Mongolian patients is worse than that of the Han patients. The one-year and three-year clinical remis-sion rate of the Mongolian patients are lower than those of the Han patients.

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备注/Memo

备注/Memo:

基金项目：内蒙古自治区卫生计生科研计划项目（201701110） 作者简介：许英，大学本科，主任医师，研究方向：内分泌 通信作者：许英，E-mail: tlxuying@126.com

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更新日期/Last Update: 2019-04-28