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[1]初旭,刘永兴,党新文,等.皮下免疫和舌下免疫治疗尘螨过敏变应性鼻炎的疗效和安全性评估[J].慢性病学杂志,2018,(8):1015-1018.
　CHU Xu*,LIU Yong-xing,DANG Xin-wen,et al.Analysis on curative effect and safety assessment of SCIT and SLIT treatment on the dust mites allergic rhinitis[J].,2018,(8):1015-1018.
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皮下免疫和舌下免疫治疗尘螨过敏变应性鼻炎的疗效和安全性评估(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2018年8期
页码:
1015-1018
栏目:
论　著
出版日期:
2018-08-31

文章信息/Info

Title:
Analysis on curative effect and safety assessment of SCIT and SLIT treatment on the dust mites allergic rhinitis
作者:
初旭1;  刘永兴2;  党新文3;  周永红4;  赵咪1
宝鸡市第五人民医院（1. 耳鼻喉科；2. 神经外科；3. 外二科；4. 骨科），陕西宝鸡722405
Author(s):
CHU Xu*;  LIU Yong-xing;  DANG Xin-wen;  ZhOU Yong-hong;  ZHAN Mi
*Ear-Nose-Throat Department, The Fifth People’s Hospital, Baoji, Shanxi 722405, China Corresponding author: CHU Xu, E-mail: 13636751123@163.com
关键词:
皮下免疫; 舌下免疫; 尘螨过敏变应性鼻炎
Keywords:
Subcutaneous immunization;  Sublingual immunization;  Dust mites allergic rhinitis
分类号:
R765.21
DOI:
-
摘要:
目的探讨皮下免疫（SCIT） 和舌下免疫（SLIT） 治疗尘螨过敏变应性鼻炎的疗效和安全性，为临床 治疗提供参考。方法选取2013 年12 月—2015 年6 月宝鸡市第五人民医院收治的78 例尘螨过敏性鼻炎患者作 为研究对象，随机分为SCIT 组和SLIT 组，分别给予皮下治疗和舌下治疗，比较两组疗效、屋尘螨IgG4 水平和 不良反应发生率。结果SCIT 组和SLIT 组总有效率无明显差异（89.74% vs. 87.18%，P>0.05）。两组治疗后 6、14 周和52 周后较治疗前IgG4 水平均有显著提高（P<0.05），SCIT 组治疗6、14 周时屋尘螨IgG4 水平明显高 于SLIT 组（P<0.05），但52 周时两组差异无统计学意义（P>0.05）。两组不良反应发生率差异无统计学意义 （1.28% vs. 1.54%，P>0.05）。治疗后两组患者的RQLQ 评分均有下降（P 均<0.05），两组间鼻部症状和实际问 题2 个维度评分差异有统计学意义（P<0.05）。结论SCIT 和SLIT 治疗尘螨过敏变应性鼻炎均具有较好的效 果，均可改善患者生活质量，SCIT 脱敏治疗发挥作用速度优于SLIT。
Abstract:
Objective To observe and evaluate the effect and safety subcutaneous immunization （SCIT） and sublingual immune immunization （SLIT） in the treatment of dust mites allergic rhinitis. Methods From December 2013 to June 2015, 78 cases with dust mites allergic rhinitis in the Fifth People’s Hospital were selected and randomly divided into SCIT group and SLIT group by different treatment methods. Curative effect, IgG4 level of house dust mites, the incidence of adverse reactions between the two groups were compared. Results There was no significant difference in efficient of two group （89.74% vs. 87.18%, P>0.05） . After 6, 14, 52 weeks of treatment, the IgG4 levels of dust mites in the two groups were increased significantly （P<0.05） , and the IgG4 levels of dust mites after 6, 14 weeks in SCIT group were higher than thosse in SLIT group （P<0.05） , but after 52 weeks there was no significant difference between the two groups （P>0.05） . There was no significant difference in the incidence of adverse reactions between the two groups （1.28% vs. 1.54%, P> 0.05） . RQLQ scores of the two groups were decreased after treatment （P<0.05） , and there were significant differences in the nasal symptoms and practical problems between the two groups （P< 0.05） . Conclusion Both SCIT and SLIT could achieve good treatment effect and improve the quality of life. SCIT may work faster.

参考文献/References:


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备注/Memo

备注/Memo:
作者简介：初旭，本科，主治医师，研究方向：耳鼻喉科 通信作者：初旭，E-mail：13636751123@163.com
更新日期/Last Update: 2018-08-30