|本期目录/Table of Contents|

[1]唐晓丽,王冬雪.抗结核固定剂量复合剂对初治活动性肺结核治疗效果观察[J].慢性病学杂志,2018,(7):871-873.
　TANG Xiao-li,WANG Dong-xue.Therapeutic effect of antituberculous fixed dose compound on patients with active pulmonary tuberculosis[J].,2018,(7):871-873.
点击复制

抗结核固定剂量复合剂对初治活动性肺结核治疗效果观察(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2018年7期
页码:
871-873
栏目:
论　著
出版日期:
2018-07-30

文章信息/Info

Title:
Therapeutic effect of antituberculous fixed dose compound on patients with active pulmonary tuberculosis
作者:
唐晓丽;  王冬雪
北京市密云区结核病防治所，北京101500
Author(s):
TANG Xiao-li;  WANG Dong-xue
Miyun Tuberculosis Control Institute, Beijing 101500, China Corresponding author: TANG Xiao-Li, E-mail: tangxiaolisw@163.com
关键词:
固定剂量复合剂; 初治活动性肺结核; 肺结核病灶
Keywords:
Fixed-dose compound;  Initial active tuberculosis;  Pulmonary lesions
分类号:
R521
DOI:
-
摘要:
目的探讨抗结核固定剂量复合剂（FDC） 治疗初治活动性肺结核的临床疗效，为临床治疗提供参考。 方法选取2012 年7 月—2016 年12 月北京市密云区结核病防治所收治的610 例初治活动性肺结核患者，随机分 为治疗组（310例） 和对照组（300例），采用病例对照研究方法，治疗组采用抗结核FDC，对照组采用常规抗结 核药板式组合药，对比两组患者第2、6 个月肺部病灶部位吸收或缩小情况，第2、5、6 个月痰菌转阴率，不良反 应发生率等情况。结果治疗第2、6 个月，两组病灶吸收率和病灶缩小率比较，差异均无统计学意义（P＞ 0.05）。治疗组病灶吸收总有效率为91.29%，明显高于对照组的70.33%，差异有统计学意义（P<0.05）。治疗第 2、5、6 个月，两组患者痰菌阴转率比较，差异均有统计学意义（P≤0.001）。两组不良反应发生率比较，差异无 统计学意义（P=0.348）。结论FDC 是一种安全、有效，易被患者接受的抗结核制剂。
Abstract:
Objective To observe the clinical effect of antituberculous fixed dose compound （FDC） on curing initial active tuberculosis, and to provide reference for clinical treatment. Method Totally 610 tuberculosis patients frome Miyun Tuberculosis Control Institute were collected and divided into two groups, the treatment group was treated with FDC, and the control group was treated with conventional antituberculous drugs. The absorption and reduction of pulmonary lesions at the 2nd and 6th month, sputum negative rate at the 2nd, 5th and 6th month, and adverse reaction rate were observed and compared between the two groups. Results There were no significant differences of absorption and reduction of pulmonary lesions at the 2nd and 6th month between the treatment group and the control group （P>0.05） . The total effective rate of lesion absorption in the treatment group was 91.29%, which was significantly higher than that in the control group （70.33%, P<0.05） . There was significant difference in sputum negative rate between the two groups at the 2nd, 5th and 6th month after treatment （P≤0001） . There was no significant difference in the incidence of adverse reactions between the two groups （P=0.348） . Conclusion FDC is a safe, efficient and easily accepted anti- tuberculosis preparation.

参考文献/References:


[1] 黄诚. 抗结核固定剂量复合剂治疗肺结核疗效观察[J]. 江苏预防 医学,2005,16(3):31-33.
[2] Would Health Organization Tuberculosis Program. Treatment of tuberculosis guidelines for national programs [R]. Geneva: WHO,1993.
[3] 高薇薇,李琦,高孟秋,等.特殊人群结核病治疗[M].北京:科学出 版社,2011:22-36.
[4] 中国疾病控制中心. 中国结核病防治规划实施工作指南[M]. 北 京：中国协和医科大学出版社,2008:25-26.
[5] 蔡薛芳,冯月娟. 国产固定剂量复合剂治疗初治涂阳肺结核疗效 观察[J].浙江预防医学杂志,2010,22(7):21-23
[6] 中华医学会.临床诊疗指南(结核病分册)[M].北京:人民卫生出版 社,2005:81-82．
[7] 全国第五次结核病流行病学抽样调查技术指导组,全国第五次结 核病流行病学抽样调查办公室.2010年全国第五次结核病流行病 学抽样调查报告[J].中国防痨杂志,2012,34(8):485-508．
[8] Listed N. The promise and reality of fixed- dose combinations with rifampicin : A joint statement of the International Union Against Tuberculosis and Lung Disease and the tuberculosis programme of the World Health Organization [J]. Tubercle & Lung Disease, 1995,75(3):180-181.
[9] 成诗明,钟球,郑金风,等. 固定剂量复合剂在国家结核病防治规 划中的应用研究[J].中国防痨杂志,2007,29(2):111-116．
[10] 聂志学,应潜,汪仕文,等. 固定剂量复合剂治疗初治涂阳肺结核 效果分析[J].现代预防医学,2012,39(8):2043-2046.

备注/Memo

备注/Memo:
作者简介： 唐晓丽， 大学本科， 副主任医师， 研究方向： 结核病防治 通信作者：唐晓丽，E-mail：tangxiaolisw@163.com
更新日期/Last Update: 2018-07-30