|本期目录/Table of Contents|

[1]李树民,刘帆,王枭鹰,等.ACE/ACE2与肾脏疾病的的研究进展[J].慢性病学杂志,2016,(01):59-64.
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ACE/ACE2与肾脏疾病的的研究进展(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2016年01期
页码:
59-64
栏目:
综述
出版日期:
2016-02-15

文章信息/Info

Title:
-
作者:
李树民; 刘帆; 王枭鹰; 杨秀红
华北理工大学基础医学院生理教研室，河北省慢性疾病重点实验室， 唐山市慢性病临床基础研究重点实验室，河北 唐山 063000
Author(s):
-
关键词:
血管紧张素转换酶; 血管紧张素转换酶2; 糖尿病肾病; 高血压; 肾素血管紧张素系统
Keywords:
-
分类号:
R587.1
DOI:
-
摘要:
肾素血管紧张素系统（renin angiotensin systems，RAS）在肾脏功能的调控中发挥了关键作用， RAS的激活显著影响肾脏疾病的进展。RAS包括经典的ACE-AngII-AT1轴和新发现的ACE2-Ang1-7-Mas轴，二者通过不同机制发挥相反的作用。血管紧张素转换酶（ACE）和血管紧张素转换酶2 （ACE2）是RAS的重要组成成分，主要功能是维持ACE-AngII-AT1轴和ACE2-Ang1-7-Mas轴之间 的稳态。两种酶在肾脏高表达，肾脏ACE/ CE2比值对多种肾脏疾病，包括糖尿病肾病，高血压，原发性 肾小球疾病，慢性肾脏疾病等都有显著影响。本文对ACE和ACE2在人类和动物不同肾脏疾病状态中的 研究进展作综述。
Abstract:
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参考文献/References:

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备注/Memo

备注/Memo:
作者简介：李树民，研究生，副教授，研究方向： RAAS系统与器官缺血再灌注损伤 通信作者：李树民，E-mail:lishumin1204@163.com
更新日期/Last Update: 2016-03-18