|本期目录/Table of Contents|

[1]黄聪华.慢性阻塞性肺病发病机制研究进展[J].慢性病学杂志,2014,(01):66-68.
点击复制

慢性阻塞性肺病发病机制研究进展(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2014年01期
页码:
66-68
栏目:
综述
出版日期:
2014-02-25

文章信息/Info

Title:
-
作者:
黄聪华
上海市仁济医院急诊科，上海200001
Author(s):
-
关键词:
慢性阻塞性肺病; 发病机制; 进展
Keywords:
-
分类号:
R563.9
DOI:
-
摘要:
慢性阻塞性肺病（COPD）是呼吸系统最常见的疾病之一，其病情呈进行性发展，给患者和社会带来 沉重负担。目前关于COPD的具体病因尚不清楚，目前认为其发生和发展涉及到炎症、代谢酶、氧化应激 等多个方面，各种因素相互刺激，互为因果。本文就COPD发病机制研究进展作一综述。
Abstract:
-

参考文献/References:

[1] Tam A, Sin DD. Pathobiologic mechanisms of chronic obstruc? tive pulmonary disease［J］．Med Clin North Am,2012,96 (4):681-698.
[2］Gooptu B, Ekeowa UI, Lomas DA. Mechanisms of emphyse? ma inα1-antitrypsin deficiency: molecular and cellular insights ［J］．EurRespir J,2009,34(2):475-88.
[3］Stoller JK,Aboussouan LS. A review ofα1-antitrypsin defi? ciency ［J］．Am J Respir Crit Care Med ,2012,185(3): 246-59.
[4］ Forey BA, Thornton AJ, Lee PN. Systematic review with meta- analysis of the epidemiological evidence relating smok? ing to COPD, chronic bronchitis and emphysema ［J］．BMC Pulm Med ,2011,11:36.
[5］Eisner MD, Anthonisen N, Coultas D,et al. An official American Thoracic Society public policy statement:novel risk factors and the global burden of chronic obstructive pulmo? nary disease［J］．Am J Respir Crit Care Med ,2010,182 (5): 693-718.
[6］Eisner MD, Anthonisen N, Coultas D,et al. An official American Thoracic Society public policy statement: novel risk factors and the global burden of chronic obstructive pulmonary disease［J］．Am J Respir Crit Care Med,2010,182(5) : 693-718.
[7］Lindberg A, Eriksson B, Larsson LG,et al. Seven-year cu? mulative incidence of COPD in an age-stratified general popu? lation sample［J］．Chest,2006,129(4):879-885.
[8］Lokke A, Lange P, Scharling H,et al. Developing COPD: a 25year follow up study of the general population［J］．Tho? rax ,2006,61(11):935-939.
[9］Ko FW, Hui DS. Air pollution and chronic obstructive pulmo? nary disease［J］．Respirology,2012,17(3):395-401.
[10］Hu G, Zhou Y, Tian J,et al.Risk of COPD from exposure to biomass smoke［J］．Chest,2010,138(1):20-31.
[11］Decramer M, Janssens W, Miravitlles M. Chronic obstructive pulmonary disease［J］．Lancet,2012,379(9823):1341-1351.
[12］Shapiro SD, Ingenito EP. The pathogenesis of chronic obstruc? tive pulmonary disease: advances in the past 100years［J］． Am J RespirCellMolBiol,2005,32(5):367-372.
[13］ Hunninghake GW, Davidson JM, Rennard S,et al. Elastin fragments attract macrophageprecursorstodiseasedsitesinpul? monaryemphysema［J］．Science,1981,212(4497):925-927.
[14］Hunnighake GM, Cho MH, Tesfaigzi Y,et al. MMP12, lung function, and COPD in high-risk populations［J］．N Engl J Med ,2009,361(27):2599-2608.
[15］Global Initiative for Chronic Obstructive Lung Disease. Glob? al strategy for the diagnosis, management and prevention of Chronic Obstructive Pulmonary Disease (Revised 2011). Available from: http://www.goldcopd.org/uploads/users/ files/ GOLD_Report_2011_Feb21_pdf, accessed on Septem? ber16,2012.
[16］Braber S, Thio M, Blokhuis BR,et al. An association be? tween neutrophils and immunoglobulin free light chains in the pathogenesis of chronic obstructive pulmonary disease［J］． Am J RespirCritCare Med ,2012,185(8):817-824.
[17］Singh B, Arora S, Khanna V. Association of severity of COPD with IgE and interleukin-1beta［J］．Monaldi Arch Chest Dis,2010,73(2):86-87.
[18］Shapiro SD, Ingenito EP. The pathogenesis of chronic obstruc? tive pulmonary disease: advances in the past 100years［J］． Am J RespirCellMolBiol,2005,32(5):367-372.
[19］Tkác J, Man SF, Sin DD. Systemic consequences of COPD ［J］．TherAdv RespirDis,2007,1(1):47-59.
[20］Thomsen M, DahlM, Lange P,etal. Inflammatory biomark? ers and co-morbidities in chronic obstructive pulmonary disease ［J］．Am J RespirCritCare Med ,2012,186(10):982-988.
[21］Mouded M, Egea EE, Brown MJ,et al.Epithelial cell apopto? sis causes acute lung injury masquerading as emphysema［J］． Am J RespirCellMolBiol,2009,41(4):407-414.
[22］Demedts IK, Demoor T, Bracke KR,et al.Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema［J］． RespirRes ,2006,7:53.
[23］Massaro GD, Massaro D. Retinoic acid treatment abrogates elastase- induced pulmonary emphysema in rats［J］．Nat Med ,1997,3(6):675-677.
[24］ Gordon C, Gudi K, Krause A,et al.Circulating endothelial microparticles as a measure of early lung destruction in ciga? rette smokers［J］．Am J RespirCrit Care Med,2011,184 (2):224-32.

备注/Memo

备注/Memo:
作者简介：黄聪华，硕士，住院医师，主要从事急诊科临床 诊疗工作 通信作者：黄聪华，E-mail: cong030243@sina.com
更新日期/Last Update: 2014-01-30