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[1]张皓然,王志军,崔圆.贝尼地平对原发性高血压患者24 h 动态血压及靶器官功能的影响[J].慢性病学杂志,2015,(6):646-649.
　ZHANG Hao-ran*,WANG Zhi-jun,CUI Yuan.The impact of Benidipine on 24-hour ambulatory blood pressure and target organ function in primary hypertension patients[J].,2015,(6):646-649.
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贝尼地平对原发性高血压患者24 h 动态血压及靶器官功能的影响(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2015年6期
页码:
646-649
栏目:
论　著
出版日期:
2015-12-27

文章信息/Info

Title:
The impact of Benidipine on 24-hour ambulatory blood pressure and target organ function in primary hypertension patients
作者:
张皓然1; 2;  王志军1;  崔圆2
1.华北理工大学附属医院心内科，河北唐山063000； 2.承德医学院附属医院心内科，河北承德067000
Author(s):
ZHANG Hao-ran*;  WANG Zhi-jun;  CUI Yuan
*Department of Cardiology, Affiliated Hospital of North China Polytechnic University, Tangshan, Hebei 063000, China Corresponding author: WANG Zhi-jun, E-mail: wzj300@163.com
关键词:
贝尼地平; 原发性高血压; 24 h 动态血压; 靶器官功能
Keywords:
Benidipine;  Primary hypertension;  24 hours ambulatory blood pressure;  Target organ function
分类号:
R544.1
DOI:
-
摘要:
目的探讨贝尼地平对原发性高血压患者24 h 动态血压疗效及对靶器官的影响。方法连续选取 2013 年6 月1 日-12 月31 日在承德医学院附属医院心内科门诊及住院部首次确诊为原发性高血压的患者共 197 例， 口服贝尼地平（4 mg， 1 次） 连续治疗3 个月。治疗前后分别进行24 h 动态血压检测， 并记录 TG、TC、HDL-C、LDL-C、肌酐、尿酸、尿素氮、β微球蛋白、心电图、心脏超声等相关指标。计量资 料组内比较采用配对t 检验。结果治疗3 个月后，本组患者24 h 血压分布的形态变化、24 h 平均血压、 白昼平均血压、夜间平均血压、24 h 收缩压变异率、24 h 舒张压变异率均低于治疗前，差异具有统计学意 义(均P<0.05)；HDL-C、LDL-C、TG、TCH 水平低于治疗前，但差异无统计学意义(均P>0.05)；治疗 后β微球蛋白、尿素氮、肌酐、尿酸水平均低于治疗前，差异具有统计学意义(均P<0.05)；治疗后心电图 ST 段压低例数较前减少（P<0.05）； 治疗前后E/A 值差异有统计学意义（P<0.05）。结论贝尼地平能 24 h 长期而缓慢的降血压，效果好，且可同时减少蛋白尿、保护肾功能，无明确降脂作用；贝尼地平还具 有改善左室功能作用，是临床应用前景广泛的一类降压药物。
Abstract:
Objectives To investigate effect of benidipine on 24-hour ambulatory blood pressure in patients with primary hypertension and on the function of target organs. Methods A total of 197 outpatients and inpatients with primary hypertension visited the Cardiology Department of the Affiliated Hospital of Chengde Medical College from June 1, 2013 to December 31, 2013 were selected in this study. All patients were oral administered benidipine (4 mg once morning) continuously for 3 months, and 24- hour ambulatory blood pressure, urea nitrogen, creatinine, uric acid, β2- microglobulin, electrocardiogram, echocardiographic and other related indicators were detected before and after the monitoring of treatment. Results After 3 months of treatment, the 24-hour, daytime, night time mean blood pressure were significantly decreased. And the 24- hour systolic and diastolic blood pressure variation rate were significantly improved. After treatment morphological changes of the distribution of 24-hour blood pressure were significantly improved. And β2- microglobulin, urea nitrogen, creatinine, uric acid levels were significantly improved. Post-treatment left ventricular diastolic function E/A index was significantly higher than that before the treatment. The number of cases with ST segment depression after treatment was significantly reduced. Conclusions Benidipine antihypertensive effect is dramatic, including 24- hour and long term. At the same time, Benidipine can protect renal function by improving urea nitrogen, uricacid, β2-microglobulin, creatinine level. Benidipine improves left ventricular diastolic function E/A index.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介：张皓然，硕士研究生，住院医师，研究方向：高血压的基础和临床研究 通信作者：王志军，E-mail: wzj300@163.com
更新日期/Last Update: 2015-12-27