|本期目录/Table of Contents|

[1]禤玉梅,陈芳.抗生素联合糖皮质激素治疗老年慢性支气管炎急性发作的疗效分析[J].慢性病学杂志,2014,(04):261-263.
　XUAN Yu-mei,CHEN Fang.Clinical efficacy of dexamethasone combined with sulbactam sodium in treatment of acute exacerbation of chronic bronchitis among elderly population[J].,2014,(04):261-263.
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抗生素联合糖皮质激素治疗老年慢性支气管炎急性发作的疗效分析(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2014年04期
页码:
261-263
栏目:
论著
出版日期:
2014-06-27

文章信息/Info

Title:
Clinical efficacy of dexamethasone combined with sulbactam sodium in treatment of acute exacerbation of chronic bronchitis among elderly population
作者:
禤玉梅; 陈芳
广州市黄埔区黄埔街社区卫生服务中心，广东 广州 510700
Author(s):
XUAN Yu-mei;  CHEN Fang
HuangpujieCommunity HealthServiceCenterofHuangpuDistrict,Guangzhou,Guangdong510700,China Correspondingauthor:XUANYu-mei,E-mail:457650087@qq.com
关键词:
舒巴坦钠; 地塞米松; 老年; 慢性支气管炎
Keywords:
Sulbactam sodium;  Dexamethasone;  The elderly;  Chronic bronchitis
分类号:
R181.2
DOI:
-
摘要:
目的 观察抗生素联合糖皮质激素治疗老年慢性支气管炎急性发作的临床疗效。方法 选取广州市黄 埔区黄埔街社区卫生服务中心2010年1月~2012年1月收治的经确诊的慢性支气管炎急性发作的老年患者 108例，用随机分组的方法分为两组,每组54例。对照组给予舒巴坦钠2 g溶于5%葡萄糖注射液100 ml 中，静脉滴注，2次/d，7 d为1个疗程；对于病情严重的患者联合应用β-受体激动剂口服；对于伴有喘息 的患者给予多巴胺10 ml，溶于5%葡萄糖注射液250 ml中，静脉滴注，1次/d。观察组在对照组的治疗基 础上加用糖皮质激素，将5~10 mg地塞米松溶于5%葡萄糖注射液500 ml中，静脉滴注，1次/d，7 d为 1个疗程。比较两组患者治疗后的临床疗效、症状消失时间及不良反应发生率。结果 观察组有效率为 88.89%，对照组为70.37%，观察组患者病情控制效果明显优于对照组，差异有统计学意义(χ 2 =5.71，P< 0.05)；观察组的咳嗽、喘息消失时间和用药实施时间明显短于对照组，差异有统计学意义（t=8.438，P< 0.05；t=5.611，P<0.05；t=6.974，P<0.05）；治疗期间药物不良反应发生率观察组明显低于对照组，差异 有统计学意义（χ 2 =4.70，P<0.05）。结论 抗生素联合糖皮质激素治疗老年慢性支气管炎急性发作临床效 果显著，且安全性较好。
Abstract:
Objective To observe the clinical efficacy of dexamethasone combined with sulbactam sodium in treatment of acute exacerbation of chronic bronchitis among elderly population. Methods108cases elderly people, who were diagnosed with acute exacerbation of chronic bronchitis, were assigned ran-domly into two groups. People in control group were given intravenous infusion, which contained sul-bactam sodium 2g dissolving in 100ml5%-glucose intravenous infusion, twice per day for7days as one treatment period. Patients who were seriously ill were given additional oral beta agonists. Patients with wheeze syndrome were giving additional dopamine10ml dissolving in250ml5%-glucose intrave-nous infusion, once per day. Patients in intervention group were given dexamethasone 5-10mg dissolv-ing in 500ml5%-glucose intravenous infusion on top of the treatment of control group, once per day for 7days as one treatment period. Clinical symptoms, symptoms lasting duration, and the incidence of adverse reactions were compared between the two groups. Results The effective rate of intervention group was 88.89% which was statistically significantly higher than70.37% of control group (χ 2 =5.71,P<0.05); the time of disappearance of cough, wheeze and drug implement duration were statistically sig-nificant between the two groups (t=8.438, P<0.05; t=5.611, P<0.05; t=6.974, P<0.05respectively); the difference of the incidence of adverse reactions between the two groups was also statistically signifi-cant (χ 2 =4.70, P<0.05). Conclusions Dexamethasone combined with sulbactam sodium in treatment of acute exacerbation of chronic bronchitis in elderly patients is more effective and relatively safer than using sulbactam sodium alone.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介：禤玉梅，大专，主管药师，主要从事药学研究工作 通信作者：禤玉梅，E-mail：457650087@qq.com
更新日期/Last Update: 2014-04-30