|本期目录/Table of Contents|

[1]程慧娟,周兰.益气活血汤和芪苈强心胶囊治疗LVEF正常的心力衰竭的临床效果[J].慢性病学杂志,2020,21(12):1802-1805.
　CHENGHui-juan,ZHOULan.Clinical effect of Yiqi Huoxue decoction and Qili Qiangxin capsule on treatment of heart failure with normal left ventricular ejection fraction[J].,2020,21(12):1802-1805.
点击复制

益气活血汤和芪苈强心胶囊治疗LVEF正常的心力衰竭的临床效果

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
21
期数:
2020年12期
页码:
1802-1805
栏目:
论　著
出版日期:
2020-12-28

文章信息/Info

Title:
Clinical effect of Yiqi Huoxue decoction and Qili Qiangxin capsule on treatment of heart failure with normal left ventricular ejection fraction
作者:
程慧娟; 周兰
蚌埠医学院第一附属医院，安徽 蚌埠 233000
Author(s):
CHENGHui-juan; ZHOULan
DepartmentofCardiology,theFirstAffiliated HospitalofBengbuMedicalCollege, Bengbu,Anhui233004,China Corrspondingauthor: ZHOULan,E-mail:dingxin2@aliyun.com
关键词:
益气活血汤; 芪苈强心胶囊; 心力衰竭; 气虚血瘀证
Keywords:
Yiqi Huoxue decoction;  Qili Qiangxin capsules;  Heart failure;  Qi deficiency and blood stasis syndrome
分类号:
R656.9
DOI:
-
摘要:
目的 探讨益气活血汤、芪苈强心胶囊治疗左心室射血分数（LVEF）正常的心力衰竭患者的治疗效 果。方法 选取蚌埠医学院第一附属医院接受诊治的180例LVEF正常的心力衰竭（气虚血瘀证）患者作为研 究对象，采用随机数表法分为四组，每组45例。其中，对照组采用基础治疗，芪苈强心胶囊组采用基础治疗+芪 苈强心胶囊治疗，益气活血汤组采用基础治疗+益气活血汤治疗，联合组采用基础治疗+芪苈强心胶囊+益气活 血汤治疗，四组均治疗12周。比较四组患者治疗前后中医证候积分、临床疗效、心功能变化及不良反应发生情 况。结果 治疗后四组中医证候积分均下降，且联合组最低，差异有统计学意义（P<0.01）；四组总有效率比较 差异有统计学意义，且联合组最高，差异有统计学意义（P<0.01）；治疗后四组左心室收缩末期内径（LVESD） 和左室舒张末期内径（LVEDD）均降低，且联合组最低，心脏指数（CI）最高，差异有统计学意义（P<0.05）； 四组不良反应发生率比较，差异无统计学意义（P>0.05）。结论 在基础治疗的基础上，采用益气活血汤和芪苈 强心胶囊辅助治疗LVEF正常的心力衰竭，能够缓解临床症状体征，提高临床疗效，改善心功能，安全性好。
Abstract:
Objective To investigate the therapeutic effect of Yiqi Huoxue decoction and Qili Qiangxin capsule on normal left ventricular ejection fraction（LVEF）patients with heart failure. Methods Ato-tal of 180 patients with heart failure of Qi deficiency and blood stasis type were chosen and randomly divided into 4 groups, 45 cases in each group. The control group was treated with basic treatment; Qi-li Qiangxin capsule group was treated with basic treatment and Qili Qiangxin capsule; Yiqi Huoxue de-coction group was treated with basic treatment and Yiqi Huoxue decoction; the combined group was treated with basic treatment, Qili Qiangxin capsule, and Yiqi Huoxue decoction. All the groups were treated for 12 weeks. The changes of TCM syndrome score, clinical efficacy, cardiac function and ad-verse events were observed and compared between the two groups before and after treatment. Results After treatment, TCM syndrome scores of the four groups were all decreased（P<0.05）, and the combined group was lower than others（P<0.01）. The differences in total effective rate of the four groups were statistically significant（P<0.05）, and the combined group was higher than others（P< 0.01）. After treatment, the left ventricular end-systolic diameter （LVESD）and left ventricular end-diastolic diameter（LVEDD）in the four groups were decreased significantly （P<0.05）, and LVESD and LVEDD in the combined group were lower than those in other groups; cardiac indexes（CI）inthe combined group was higher than that in other groups（P<0.05）. There was no significant differ-ence in the incidence of adverse events among the four groups（P>0.05）. Conclusion On the basis of basic treatment for patient with heart failure and normal LVEF, the use of Yiqi Huoxue decoction and Qili Qiangxin capsule can alleviate clinical symptoms, improve clinical efficacy and cardiac func-tion, and it is a safe method.

参考文献/References:

[1] Chaudhry SP, Stewart GC. Advanced heart failure: preva-lence, natural history, and prognosis [J]. Heart Fail Clin, 2016,12(3):323-333. [2] Tran HA, Lin F, Greenberg BH. Potential new drug treatments for congestive heart failure [J]. Expert Opin In-vestig Drugs,2016,25(7):811-826. [3] 王科,张弘,李曦.益气活血汤对气虚血瘀型心力衰竭患者中医证 候及生活质量的影响[J].陕西中医,2018,39(1):32-34. [4] 魏琳萍.芪苈强心胶囊联合曲美他嗪片治疗冠心病舒张性心力衰 竭的疗效研究[J].中华全科医学,2016,14(12):2142-2143. [5] 于润江.中国内科专家经验文集[M].沈阳:沈阳出版社,1991: 7717-7725. [6] 郑筱萸.中医新药临床研究指导原则(试行)[M].北京:中国医药科 技出版社,2002:295-298. [7] 许泽峰.新编临床心脏内科学[M].北京:科学技术文献出版社, 2013:98-102. [8] 申冬冬.桂枝甘草汤对心力衰竭大鼠心肌凋亡及心肌细胞TGF-β1、ICAM-1表达的影响[J].中华中医药学刊,2018,5(4):2-6. [9] 邸琳,刘新宇,徐雅娟,等.人参四逆颗粒对腹主动脉狭窄所致心 力衰竭大鼠的治疗作用[J].中国老年学杂志,2018,38(13):21-25. [10] 陈晓虎.中医药在心力衰竭防治中的地位和作用[J].中国中西医 结合杂志,2017,37(10):1157-1158. [11] 沈志方.注射用红花黄色素联合美托洛尔治疗冠心病心力衰竭的 临床研究[J].现代药物与临床,2018,33(6):1357-1360. [12] 陈火胜.芪苈强心胶囊治疗顽固性心力衰竭的临床效果观察[J]. 临床医学工程,2015,22(10):1354-1358.

备注/Memo

备注/Memo:
作者简介：程慧娟，硕士，住院医师，研究方向：中医药防治内科杂病、妇科杂病、及癌症术后放化疗后的中医诊疗 通信作者：周兰，E-mail: dingxin2@aliyun.com
更新日期/Last Update: 2020-12-28