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《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:

21

期数:

2020年11期

页码:

1627-1630

栏目:

论　著

出版日期:

2020-11-28

文章信息/Info

Title:

Clinical effect of escitalopram combined with amisulpride in the treatment of schizophrenia with negative symptoms

作者:

赵珂

徐州市民政精神病医院，江苏 徐州 221000

Author(s):

ZHAOKe

Xuzhou Civil AffairsPsychiatricHospital,Xuzhou,Jiangsu221000,China Correspondingauthor:ZHAOKe,E-mail:qwbl26@163.com

关键词:

艾司西酞普兰; 氨磺必利; 阴性症状; 精神分裂症; 治疗效果

Keywords:

Escitalopram;  Amsulfopril;  Negative symptoms;  Schizophrenia;  Therapeutic effect

分类号:

R749.3

DOI:

-

摘要:

目的 探讨艾司西酞普兰联合氨磺必利治疗阴性症状为主的精神分裂症的临床效果。方法 选取 2015年1月至2017年1月徐州市民政精神病医院收治的阴性症状为主的83例精神分裂症住院患者作为研究对象， 根据随机数字表法分为对照组42例和观察组41例。其中，对照组予以氨磺必利治疗，观察组予以艾斯西酞普兰 联合氨磺必利治疗，共治疗8周。比较两组患者治疗有效率，治疗前后阴性症状量表（SANS）、神经心理学 （Stroop实验）评分，治疗期间不良反应及预后情况。结果 观察组治疗总有效率为87.70%，高于对照组的 71.43%，差异有统计学意义（P<0.05）。两组患者治疗后SANS量表评分与总分均低于治疗前，且观察组患者治 疗后SANS量表评分与总分均低于对照组，差异有统计学意义（P<0.05）。治疗后两组患者Stroop实验评分高于 治疗前，且观察组患者治疗后Stroop实验评分高于对照组，差异有统计学意义（P<0.05）。观察组患者复发 率为12.20%（5/41），低于对照组的28.57%（12/42），差异有统计学意义（P<0.05）。结论 艾司西酞普兰联 合氨磺必利治疗阴性症状为主的精神分裂症效果显著，预后较好，可有效改善患者临床症状及执行功能。

Abstract:

Objective To explore the clinical effect of escitalopram combined with amisulpride in the treatment of schizophrenia with negative symptoms. Methods From January 2015 to January 2017, totally 83 schizophrenic patients with negative symptoms were enrolled to this study, whom were divid-ed into two groups. The control group was received amisulpride, while the observation group was re-ceived escitalopram plus amisulpride. Both of them were treated for 8 weeks. The effective, socores of Scale for Assessment of Negative Symptoms（SANS）, Stroop test scores, and adverse reactions were compared between two groups.Results The treatment effective rate of the observation group was87.70% which was higher than that of the control group（71.43%）, and the difference was statis-tically significant （P<0.05）. After treatment, the scores of all indicators and their total scores of SANS scale in the two groups were lower than those before treatment（P<0.05）; all the scores in the observation group were lower than those in the control group（P<0.05）. The Stroop test scores of the two groups after treatment were higher than those before treatment（P<0.05）; the Stroop test score of the observation group after treatment was higher than that of the control group（P<0.05）. The recurrence rate was12.20%（5/41）in the observation group and 28.57%（12/42）in the control group,and there was significant difference between the two groups（P<0.05）. Conclusion Escitalo-pram combined with amisulfapride is effective in the treatment of schizophrenia with negative symptoms.It has a good prognosis and can effectively improve the clinical symptoms and executive function of pa-tients.

参考文献/References:

[1] 吴仲心,陈剑英,李琴芳.住院精神分裂症患者的心理特点及护理 [J].医药前沿,2016,6(13):303-304. [2] 胡琼月,张永东,田博.精神分裂症阴性症状的研究进展[J].神经 疾病与精神卫生,2016,16(3):361-364. [3] Millan MJ, Fone K, Steckler T,et al. Negative symp-toms of schizophrenia: Clinical characteristics, pathophysio-logical substrates, experimental models and prospects for improved treatment [J]. Eur Neuropsyc, 2014,24(5):645-692. [4] Nikbakhat MR, Arabzadeh S, Zeinoddini A,et al. Dulox-etine Add- On to Risperidone for Treatment of Negative Symptoms in Patients with Stable Schizophrenia: Random-ized Double- Blind Placebo- Controlled Study [J]. Phar-mac,2016:s-0042-101557. [5] 卫生部卫生统计信息中心.国际疾病分类(ICD-10)应用指导手册 [S].2001. [6] Andreasen NC, Olsen S. Negative v positive schizophre-nia. Definition and validation [J]. Arch Gen Psychiat, 1982, 39(7):789. [7] 司天梅,杨建中,舒良,等.阳性和阴性症状量表(PANSS,中文版) 的信、效度研究[J].中国心理卫生杂志,2004,18(1):45-47. [8] 姚晶,崔界峰,陈楠,等.简明阴性症状量表中文版的效度、信度检 验[J].中国心理卫生杂志,2014,28(4):302-307. [9] Schiehser DM, Bondi MW. Stroop Color-Word Test [M]. Corsini Encycl Psychol,2010. [10] 杨卫华.阿立哌唑联合音乐疗法治疗精神分裂症的疗效及对患者 生活质量的影响[J].中华全科医学,2016,14(2):261-263. [11] Huang LC, Lin SH, Tseng HH,et al. The integrated model of glutamate and dopamine hypothesis for schizo-phrenia: Prediction and personalized medicine for prevent potential treatment-resistant patients [J]. Med Hypotheses, 2020,143:110159. [12] Stahl SM. Beyond the dopamine hypothesis of schizophre-nia to three neural networks of psychosis: Dopamine, sero-tonin, and glutamate [J]. CNS spectrums, 2018,23(3):187-191. [13] 张俊峰,游非,戴炜,等.小剂量氨磺必利联合草酸艾司西酞普兰 对抑郁症患者疲乏症状的疗效[J].神经疾病与精神卫生,2019,19 (6):571-574. [14] 张志勇,原富强,程德君.奥氮平联合氨磺必利治疗精神分裂症的 效果及其对睡眠和认知功能的影响[J].国际精神病学杂志,2020, 47(1):43-45,57. [15] Lavretsky H, Laird KT, Krause-Sorio B,et al. A ran-domized double-blind placebo-controlled trial of combined escitalopram and memantine for older adults with major de-pression and subjective memory complaints [J]. Am J Geri-atr Psychiatry, 2020,28(2):178-190. [16] Tian S, Sun Y, Shao J,et al. Predicting escitalopram monotherapy response in depression: the role of anterior cingulate cortex [J]. Hum Brain Mapp, 2020,41(5):1249-1260. [17] Grimm O, Kopfer V, Kupper-Tetzel L,et al. Amisul-pride and I-DOPA modulate subcortical brain nuclei con-nectivity in resting-state pharmacologic magnetic resonance imaging [J]. Hum Brain Mapp, 2020,41(7):1806-1818. [18] Citrome L, Ouyang J, Shi L,et al. Effect of brexpipra-zole on agitation and hostility in patients with Schizophre-nia: post hoc analysis of short-and long-term studies [J]. J Clin Psychopharmacol, 2019,11(6):597-603. [19] 王丽娜,宗小芬,潘飞,等.氨磺必利联合艾司西酞普兰治疗阴性 症状为主的精神分裂症42例[J].医药导报,2014,33(8):1056-1059. [20] 李小新.氨磺必利联合艾司西酞普兰治疗精神分裂症阴性症状的 疗效观察[J].当代医学,2014,20(35):370-371. [21] 肖颖.氨磺必利联合艾司西酞普兰治疗阴性症状为主的精神分裂 症患者的效果观察[J].中国民康医学,2016,28(8):25-26.[22] Gimenez-Donoso S, Treen-Calvo D, Setien-Suero E,et al. Evaluation of verbal inhibitory control with the Stroop Test in early episodes of psychosis with the experience of traumatic events in infancy [J]. Rev Neurol, 2018,67(4): 115-120. [23] Tang X, Zhou C, Gao J, et al. Serum BDNF and GDNF in Chinese male patients with deficit schizophrenia and their relationships with neurocognitive dysfunction [J]. BMC Psychiatry,2019,19(1):254.

备注/Memo

备注/Memo:

作者简介：赵珂，大学本科，主治医师，研究方向：精神分类症治疗 通信作者：赵珂，E-mail: qwbl26@163.com

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更新日期/Last Update: 2020-11-28