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《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:

21

期数:

2020年09期

页码:

1321-1324

栏目:

论　著

出版日期:

2020-09-28

文章信息/Info

Title:

Correlation analysis of blood flow with MVD, VEGF and vascular parameters in patients with cervical cancer by three-dimensional power Doppler ultrasound

作者:

刘秋兰; 田丰魁; 李泽宽; 赵金花

山东聊城茌平区人民医院超声科，山东 聊城 252100

Author(s):

LIUQiu-lan; TIANFeng-kui; LIZe-kuan; ZHAOJin-hua

DepartmentofUltrasound,ChipingDistrictPeople’sHospital,Liaocheng,Shandong252100,China Correspondingauthor: LIUQiu-lan,E-mail:337957276@qq.com

关键词:

三维能量多普勒超声; 宫颈癌; 微血管密度; 血管内皮生长因子; 血管分级

Keywords:

Three-dimensional power Doppler ultrasound;  Cervical cancer;  Microvessel density;  Vascular endothelial growth factor;  Vascular classification

分类号:

R741

DOI:

-

摘要:

目的 探讨三维能量多普勒超声检测宫颈癌患者的血流参数与微血管密度（MVD）、血管内皮生长因子 （VEGF）的关系。方法 选取2018年1月至2019年12月山东聊城茌平区人民医院病理检查证实的40例宫颈癌 患者（宫颈癌组）、30例宫颈上皮内瘤变患者（宫颈上皮内瘤变组）以及30例慢性宫颈炎患者（对照组）进行三 维能量多普勒超声检查，检测血流参数并对对患者血管进行分级，后通过病理标本免疫组化染色，对比三组 MVD、VEGF及血管分级，并分析相关性。结果 宫颈癌组患者、宫颈上皮内瘤变组患者的MVD、VEGF均 高于对照组，且宫颈癌组患者MVD、VEGF显著高于宫颈上皮内瘤变组，差异有统计学意义（P<0.05）；宫颈 癌组患者的血流指数（FI）、血管指数（VI）以及血管化血流指数（VFI）明显高于对照组患者及宫颈上皮内瘤 变组患者，而宫颈上皮内瘤变组的VFI、VI值明显高于对照组患者，差异有统计学意义（P<0.05）；宫颈癌组血 管分级为Ⅲ级的患者其MVD、VEGF要明显高于血管分级为Ⅱ级、Ⅰ级的患者，血流参数与MVD、VEGF呈 正相关，差异有统计学意义（r=0.859，0.784，P<0.05）。结论 对宫颈癌患者采取三维能量多普勒超声检查， 可以对血流情况进行了解，对血管分级、血流参数进行掌握，并进一步加强对MVD、VEGF的检测，对于临床 检测、治疗宫颈癌患者具有一定的价值。

Abstract:

Objective To investigate the relationship between the blood flow parameters and the expres-sion of microvessel density（MVD）, vascular endothelial growth factor（VEGF）in cervical cancer pa-tients. Methods Totally40 cases of patients with cervical cancer（cervical cancer group）, 30 cases of patients with cervical intraepithelial neoplasia（cervical intraepithelial neoplasia group）and 30 cases of patients with chronic cervicitis（control group）confirmed by pathological examination in Chiping Dis-trict People's Hospital from January 2018 to December 2019 were enrolled, and three-dimensional ener-gy Doppler ultrasound examination were carried out. The blood vessels were detected and the vessel was graded and immunohistochemical staining were carried out in all patients. The MVD, VEGF and vessel classification of the three groups was compared and their correlation was analyzed.Results The MVD, VEGF in cervical cancer group and cervical intraepithelial neoplasia group were significantly higher than those in control group, and which in cervical cancer group were significantly higher than those in cervical intraepithelial neoplasia group（P<0.05）. Blood flow index （FI）, vessel index（VI）, and vascularized blood flow index（VFI）in cervical cancer group were significantly higher than those in control group and cervical intraepithelial neoplasia group, and the VFI, VI in cervical intraepi-thelial neoplasia group were significantly higher than those in control group（P<0.05）. The MVD, VEGF in patients in vascular classificationⅢwere significantly higher than those in patients inⅠ,Ⅱ vascular classification in cervical cancer group（P<0.05）. The vascular parameters were positively relat-ed with MVD, VEGF（r=0.859, 0.784, P<0.05）. Conclusion The three dimensional power dop-pler ultrasound used in patients with cervical cancer can help to effectively understand the blood flow, master the vascular classification, vascular parameter value, further strengthen the accuracy of MVD, VEGF detection results, and have certain value for clinical detection and the treatment for patients with cervical cancer.

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备注/Memo

备注/Memo:

作者简介：刘秋兰，大学本科，主治医师，研究方向：超声诊断及治疗 通信作者：刘秋兰，E-mail:337957276@qq.com

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更新日期/Last Update: 2020-09-28