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《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:

21

期数:

2020年07期

页码:

997-1003

栏目:

预防医学

出版日期:

2020-07-28

文章信息/Info

Title:

Surveillance of adverse event following immunization in Chaoyang district of Beijing from2015to2017

作者:

张彦利1; 白云骅1; 李淑萍1; 唐山贵2; 徐婧怡1; 马莹3; 张军楠1; 杨立清1; 芦强1

1.北京市朝阳区疾病预防控制中心，北京 100021； 2. 厦门大学公共卫生学院，福建 厦门 361102； 3.北京大学公共卫生学院，北京 100191

Author(s):

ZHANGYan-li * ; BAIYun-hua; LIShu-ping; TANGShan-gui; XUJing-yi; MAYing; ZHANGJun-nan; YANGLi-qing; LUQiang

*BeijingChaoyang DistrictCenterforDiseasesPreventionandControl,Beijing100021,China Corrspondingauthor:ZHANG Yan-li,E-mail:zhangyl@163.com

关键词:

疑似预防接种异常反应; 不良反应; 安全性监测

Keywords:

Adverse events following immunization;  Vaccine reaction;  Safety surveillance

分类号:

R186

DOI:

-

摘要:

目的 分析2015—2017年北京市朝阳区疑似预防接种异常反应（AEFI）流行病学特征，为日后预防接 种安全性提供依据。方法 分别通过中国AEFI信息管理系统和中国免疫规划信息管理系统收集北京市朝阳区 2015—2017年发生的AEFI个案数据和北京市朝阳区43个街乡2015—2017年各年疫苗接种时间、剂次等相关数 据信息，采用描述性流行病学方法对相关数据进行分析。结果 2015—2017年北京市朝阳区共报告AEFI 3 415例，报告发生率68.40/10万；不良反应2 926例，报告发生率58.61/10万；AEFI及不良反应报告发生率 逐年增加；AEFI及不良反应男女比例分别为1.20、1.18，年龄集中在0~6岁，散居儿童分别占89.22%和 89.99%；全年均可发生；90%街乡AEFI上报意识增加，双井街道三年总AEFI报告发生率（254.70/10万）最 高；各年不良反应报告发生率前三位的疫苗以第二类疫苗为主，A群流脑疫苗、麻风疫苗不良反应发生率逐年增 高；约92%不良反应在疫苗接种后48h内发生；肌肉注射疫苗不良反应发生率为74.23/10万；81.68%不良反应 症状为发热、局部红肿和局部硬结，所有不良反应病例预后良好。结论 北京市朝阳区2015—2017三年不良反 应发生率远低于WHO参考值，疫苗质量安全可靠，监测的敏感性有待进一步提高。

Abstract:

Objective To analyze the characteristics of adverse events following immunization（AEFI） in Chaoyang district of Beijing during 2015-2017 in order to provide evidence for safety of immuniza-tion. Methods Immunization information and AEFI data in Chaoyang district of Beijing from 2015 to 2017 were collected through the National Immunization Program Information Management System and AEFI Information Management System, respectively; descriptive epidemiological methods were used in this study. Results A total of3 415 cases of AEFI and 2 926 cases of vaccine reactions were re-ported in Chaoyang district of Beijing from 2015 to 2017, with reported incidence of 68.40/100 000 and 58.61/100 000, respectively. The incidence of AEFI and vaccine reaction increased year by year. The sex ratio of AEFI and vaccine reaction was1.20 and 1.18; the age was concentrated in 0 to 6 years old, and scattered children accounted for 89.22% and89.99%, respectively. AEFI and vaccine re-action happened every month. The awareness of reporting AEFI increased year by year with 90% of street township and Shuangjing street owned highest incidence rate with 254.70/100 000. The top three vaccines for the incidence of vaccine reactions were all category 2 vaccines and the incidence of vaccinereactions to influenza A and leprosy vaccines improved year by year. About 92% of vaccine reactions occurred within 48 hours after vaccination. Intramuscular injection stood highest incidence rate, 74.23/ 100 000. 81.68% of vaccine reaction cases were fever, local swelling and local induration, and all events had a good prognosis. Conclusion The incidence of vaccine reaction in Chaoyang district of Beijing from2015 to 2017 was much lower than the WHO reference value and the vaccines were safe and reliable, and the sensitivity of monitoring needs to be further improved then.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介：张彦利，硕士研究生，主管医师，研究方向：免疫接种 通信作者：张彦利，E-mail: zhangyl@163.com

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更新日期/Last Update: 2020-07-28