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[1]罗德红,张琴,万林,等.早期乳腺癌保乳术后全乳腺放疗瘤床同期推量的大分割调强放疗与常规分割放疗的效果对比[J].慢性病学杂志,2020,21(07):986-989.
　LUODe-hong,ZHANGQin,WANLin,et al.Comparison of the effect between hypo-fractionated-simultaneous integrated boost-intensity modulated radiotherapy and conventional radiotherapy in early-stage breast cancer after breast conserving surgery[J].,2020,21(07):986-989.
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早期乳腺癌保乳术后全乳腺放疗瘤床同期推量的大分割调强放疗与常规分割放疗的效果对比

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
21
期数:
2020年07期
页码:
986-989
栏目:
论　著
出版日期:
2020-07-28

文章信息/Info

Title:
Comparison of the effect between hypo-fractionated-simultaneous integrated boost-intensity modulated radiotherapy and conventional radiotherapy in early-stage breast cancer after breast conserving surgery
作者:
罗德红1; 张琴1; 万林1; 曹梦璐1; 陈车1; 陈睿1; 陆治江1;  金天淑1; 李顺维1; 刘伟2; 王慧静2; 刘道生2
遵义医科大学第三附属医遵义市第一人民医院（1.肿瘤科；2.甲乳外科），贵州 遵义 563200
Author(s):
LUODe-hong; ZHANGQin; WANLin; CAOMeng-lu; CHENChe; CHENRui; LUZhi-jiang;  JINTian-shu; LIShun-wei; LIUWei; WANGHui-jing; LIUDao-sheng
TheThirdAffiliatedHospital of ZunyiMedicalUniversity/FirstPeople’sHospitalofZunyi,Zunyi,Guizhou563000,China Correspondingauthor: LUODe-hong，E-mail:75800743@qq.com
关键词:
乳腺癌; 保乳手术; 瘤床同期推量照射;  大分割; 临床效益
Keywords:
Breast cancer;  Breast conserving surgery;  Hypo-fractionated-simultaneous integrated boost-intensity modulated radiotherapy;  Large division;  Clinical benefits
分类号:
R737
DOI:
-
摘要:
目的 对比分析早期乳腺癌患者保乳术后全乳腺放疗瘤床同期推量的大分割调强放疗（简称HF-SIB-IMRT）与常规分割放疗的初期临床效果及安全性。方法 选取2017年8月—2018年12月遵义市第一人民医院 收治的早期浸润性乳腺癌（pT1-2N0M0期）保乳术后的62例患者。采用随机数字表法将其分为HF-SIB-IMRT 组（32例）和常规放疗组（30例）。两组均采用全乳腺放疗瘤床同期推量的调强放疗，其中HF-SIB-IMRT组 为大分割，PTV（Planning Target Volume）40.5 Gy/15次，PGTV-tb （Planning Gross Tumor Volume-tumor bed）48Gy/15次，总疗程为3周；常规放疗组采用常规分割，PTV50Gy/25次，PGTV-tb2.4Gy/次， 总疗程5周。比较两组的局部控制率、复发率、美容效果及放疗不良反应发生率。结果 随访1年，两组局部控 制率和1年生存率均为100%，均无复发及死亡病例。HF-SIB-IMRT组和常规放疗组放疗结束后1、6个月美容 效果优良率，≤2级急性、晚期皮肤不良反应及血液毒性不良反应发生率比较，差异均无统计学意义（P>0.05）， 而HF-SIB-IMRT组的住院时间及治疗费用均明显低于常规放疗组，差异有统计学意义（P<0.05）。结论 对早期乳腺癌患者保乳术后行全乳腺放疗瘤床同期推量的大分割调强放疗，可获得较满意的近期疗效，不增加放 疗毒副反应，且具有缩短术后辅助放疗住院总时间和减少治疗费用等临床优势。
Abstract:
Objective To compare the clinical efficacy and safety of hypo-fractionated-simultaneous in-tegrated boost-intensity modulated radiotherapy（HF-SIB-IMRT）and conventional segmentation radio-therapy for early-stage breast cancer patients after breast conserving surgery. Methods From August 2017 to December 2018, 62 cases of patients with early-stage breast cancer（pT1-2N0M0 staging）under-went breast conserving surgery in the First People’s Hospital of Zunyi were enrolled and were divided into HF-SIB-IMRT group （32 cases）and conventional radiotherapy group（30 cases）according to the random number table method. The two groups all received intensity modulated radiation therapy for whole breast radiotherapy after breast conserving surgery. The HF-SIB-IMRT group received HF-SIB-IMRT, planning target volume（PTV）40.5 Gy/fifteen times，planning gross tumor volume-tu-mor bed（PGTV-tb）48 Gy/fifteen times，the total treatment course was 3 weeks. The routine radio-therapy group received conventional segmentation, PTV 50 Gy/25 times，PGTV-tb2.4 Gy/one time, the total course of treatment was 5 weeks. The local control rate, recurrence rate, cosmetic effect and incidence of radiation-related side effects were compared between the two groups. Results Both groups were followed up for at least 1 year. The local control rate and the one-year survival rate was all 100% in the two groups. During the follow-up period, there was no recurrence and death patients in both groups．There were no significant difference in cosmetic effect excellence rate on the first month and the sixth month after radiotherapy, the incidence of acute adverse events（0.05）. The hospital stay time and treatment costs in HF-SIB-IMRT group were significantly lower than those in conventional radiotherapy group（P<0.05）. Conclusion HF-SIB-IMRT after breast conserving surgery for early breast cancer patients can ob-tain satisfactory short-term curative effect, without increasing the toxicity and side effects of radiothera-py, and it also can shorten the total course of radiotherapy after breast conserving surgery and treat-ment costs．

参考文献/References:

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备注/Memo

备注/Memo:
作者简介：罗德红，博士研究生，副主任医师，研究方向：临床肿瘤 通信作者：罗德红，E-mail：75800743@qq.com
更新日期/Last Update: 2020-07-28