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《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:

21

期数:

2020年06期

页码:

824-827

栏目:

论　著

出版日期:

2020-06-28

文章信息/Info

Title:

Expression levels and clinical value of serum immunoglobulin E and hs-CRP in patients with chronic obstructive pulmonary disease

作者:

杨华1; 秦英季1; 李林栋2

1.山东聊城茌平区人民医院，山东 聊城 252100； 2.聊城市茌平区卫生健康局，山东 聊城 252100

Author(s):

YANGHua * ; QINYing-ji; LILin-dong

*People’s Hospital of Chiping District,Liaocheng,Shandong252100,China Correspondingauthor:YANG Hua,E-mial:chipingicu@sina.com

关键词:

慢性阻塞性肺疾病; 稳定期; 急性期; 免疫球蛋白E; 超敏C反应蛋白; 肺功能

Keywords:

Chronic obstructive pulmonary disease;  Stable phase;  Acute phase;  Immunoglobulin E;  High-sensitivity C-reactive protein;  Pulmonary function

分类号:

R563.9

DOI:

-

摘要:

目的 探讨慢性阻塞性肺疾病（COPD）患者血清免疫球蛋白E（IgE）、超敏C反应蛋白（hs-CRP）的 表达水平及临床意义。方法 选取山东聊城茌平区人民医院2017年2月—2020年2月收治的100例COPD患者 作为观察组，另选100例同期健康体检者作为对照组。检测各组血清IgE和hs-CRP因子水平，比较稳定期组和 加重期组，不同肺功能分级患者血清IgE和hs-CRP因子水平。结果 观察组血清IgE、hs-CRP因子均显著高 于对照组，差异均有统计学意义（P<0.05）。加重期组血清IgE、hs-CRP因子水平均显著高于稳定期组，差异均 有统计学意义（P<0.05）。不同肺功能患者血清IgE、hs-CRP因子水平比较，差异均有统计学意义（P<0.05）。 Ⅳ级组血清IgE、hs-CRP因子水平均明显高于Ⅲ级组，Ⅲ级组血清IgE、hs-CRP因子水平均显著高于Ⅱ级组， 差异均有统计学意义（P<0.05）。血清IgE、hs-CRP与肺功能分级呈正相关性（P<0.05）。结论 血清IgE、 hs-CRP参与了COPD疾病发生、发展，稳定期会明显升高，与患者肺功能呈正相关性。

Abstract:

Objective To explore the expression levels and clinical significance of serum immunoglobu-lin E（IgE）and high-sensitivity C-reactive protein（hs-CRP）in patients with chronic obstructive pul-monary disease（COPD）. Methods Totally100 patients with COPD admitted from February 2017 to February 2020 in the People’s Hospital of Chiping District were selected as the observation group, and another 100 healthy persons were selected as the control group. The levels of serum IgE and hs-CRP factors were detected and compared among different severity groups（stabilization group and aggra-vation group）and different lung function grade groups（Ⅱ-Ⅳgrades）. Results The serum IgE and hs-CRP factors in the observation group were significantly higher than those in the control group, and the differences were statistically significant（P<0.05）. The levels of serum IgE and hs-CRP factors in the exacerbation group were significantly higher than those in the stable group, and the differences were statistically significant（P<0.05）. The differences in serum IgE and hs-CRP factor levels in pa-tients with different lung functions were statistically significant （P<0.05）. The levels of serum IgE and hs-CRP factors in the grade Ⅳgroup were significantly higher than those in the grade Ⅲgroup, and the levels of serum IgE and hs-CRP factors in the grade Ⅲgroup were significantly higher than those in the grade Ⅱgroup（P<0.05）. Serum IgE and hs-CRP were positively correlated with lungfunction grade （P<0.05）. Conclusion Serum IgE and hs-CRP are involved in the occurrence and development of COPD disease and significantly increased in the stable period, and they are positively correlated with the patient’s lung function.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介：杨华，本科，主治医师，研究方向：呼吸内科 通信作者：杨华，E-mail：chipingicu@sina.com

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更新日期/Last Update: 2020-06-28