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《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:

21

期数:

2020年01期

页码:

21-23

栏目:

论　著

出版日期:

2020-01-28

文章信息/Info

Title:

Gut microbiome analysis in elderly patients with non-small cell lung cancer

作者:

归崎峰; 王安鸽; 谭中菊; 赵新秀; 杨云梅

浙江大学医学院附属第一医院老年科，杭州310003

Author(s):

GUIQi-feng; WANGAn-ge; TANZhong-ju; ZHAOXin-xiu; YANGYun-mei

DepartmentofGeriatrics,theFirstAffiliatedHospital,SchoolofMedicine,ZhejiangUniversity,Hangzhou310003,China Correspondingauthor: YANG Yun-mei,E-mail:yangyunmei2008@sina.com

关键词:

老年人; 非小细胞肺癌; 肠道菌群

Keywords:

Elderly;  Non-small cell lung cancer;  Gut microbiome

分类号:

R734.2

DOI:

-

摘要:

目的 探讨老年肺癌肠道微生态特点。方法 收集老年非小细胞肺癌（non-small cell lung cancer， NSCLC）患者26例和健康老年人49例，通过定量PCR方法检测其肠道8种产丁酸菌的组成差异。结果 和健 康老年人比较，老年NSCLC患者中除梭菌组4未见明显下降外，其余7种产丁酸菌：普拉梭菌、柔嫩梭菌、梭菌 组1、直肠真杆菌、ClusterⅣRumioococcus spp、Clostridial cluster ⅩⅣa和Roseburia spp. and E. rectale均 显著降低（P<0.05）。结论 老年NSCLC患者中存在肠道微生态失调，具体表现为产丁酸菌减少。

Abstract:

Objective To investigate the gut microbiome characteristicsof elderly lung cancer patients. Methods Totally49 healthy elderly and 26 elderly non-small cell lung cancer（NSCLC）patients were enrolled. Quantitative PCR was used to detect the difference in the composition of gut butyrate-producing bacteria between two groups. Results Compared with healthy elderly, except forClostridial cluster Ⅳwhich did not significantly decrease, the other seven butyric acid-producing bacteria, includ-ing Faecalibacteriumprausnitzii, Clostridiumleptum, Clostridial cluster I, Eubacteriumrectale, Cluster ⅣRumioococcus spp, Clostridial cluster ⅩⅣa, and Roseburia spp. and E. rectale were significantly re-duced in elderly NSCLC patients. Conclusion Elderly NSCLC patients had gut microbiome dysbio-sis, which presented as the decrease of gut butyrate-producing bacteria.

参考文献/References:

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备注/Memo

备注/Memo:

基金项目：老年病科国家临床重点专科建设项目；浙江省中 医药（中西医结合）重点学科建设计划（2017-XK- A31）；浙江省医药卫生一般研究计划 （2017-KY1-002-024） 作者简介：归崎峰，博士，副主任医师，研究方向：老年 肠道微生态 通信作者：杨云梅，E-mail：yangyunmei2008@sina.com

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更新日期/Last Update: 2020-01-28