|本期目录/Table of Contents|

[1]陈路.度洛西汀与舍曲林治疗伴有躯体症状老年性抑郁症的疗效及安全性比较[J].慢性病学杂志,2019,20(09):1321-1323.
　CHENLu.Comparison of efficacy and safety of duloxetine and sertraline in the treatment of senile depression with somatic symptoms[J].,2019,20(09):1321-1323.
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度洛西汀与舍曲林治疗伴有躯体症状老年性抑郁症的疗效及安全性比较(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
20
期数:
2019年09期
页码:
1321-1323
栏目:
论　著
出版日期:
2019-08-28

文章信息/Info

Title:
Comparison of efficacy and safety of duloxetine and sertraline in the treatment of senile depression with somatic symptoms
作者:
陈路
商丘市第二人民医院，河南 商丘 476000
Author(s):
CHENLu
ShangqiuSecondPeople's Hospital,Shangqiu,Henan476000,China Correspondingauthor:CHENLu,E-mial:151450386@qq.com
关键词:
度洛西汀; 舍曲林; 抑郁症; 老年人; 躯体症状
Keywords:
Duloxetine;  Sertraline;  Depression;  Eledrly;  Somatic symptoms
分类号:
R453
DOI:
-
摘要:
目的 比较度洛西汀与舍曲林治疗伴有躯体症状老年性抑郁症的疗效及安全性，为临床治疗提供参考。 方法 选取2017年3月—2018年3月商丘市第二人民医院收治的80例伴有躯体症状的老年性抑郁症患者，随机 分为对照组和观察组，每组40例。观察组口服度洛西汀治疗，对照组口服舍曲林治疗，两组均持续治疗6周。治 疗前后，采用汉密顿抑郁量表（HAMD）评估并比较两组抑郁状态，观察并比较两组不良反应发生情况和临床疗 效。结果 治疗前，两组各项HAMD因子评分比较，差异无统计学意义（P>0.05）；治疗后，观察组各项 HAMD因子评分均显著低于本组治疗前和同期对照组，差异有统计学意义（P<0.05）。观察组临床治疗总有效率 为97.50%，与对照组的92.50%比较，差异无统计学意义（P>0.05）。观察组不良反应总发生率为7.50%，低于对 照组的22.50%，差异有统计学意义（P<0.05）。结论 对伴有躯体症状老年性抑郁症患者采用度洛西汀治疗效 果与舍曲林类似，但前者用药安全性更高。
Abstract:
Objective To compare the efficacy and safety of duloxetine and sertraline in the treatment of senile depression with somatic symptoms. Methods Eighty elderly depressive patients with somatic symptoms were randomly divided into control group and observation group. The control group was treated with sertraline, while the observation group was treated with duloxetine, and both groups were treated for six weeks. Before and after treatment, Hamilton Depression scale （HAMD）was used to evaluate the state of depression. The occurrence of adverse reactions and clinical efficacy between the two groups were observed and compared after treatment. Results Before treatment, there was no sig-nificant difference in the HAMD scores between the two groups（P>0.05）. After treatment, the scores of HAMD factors in the observation group were significantly lower than those before treatment and the control group at the same time, and the differences were statistically significant（P<0.05）. The total effective rate of clinical treatment in the observation group was97.50%, and there was no significant difference compared with 92.50% in the control group（P>0.05）. The incidence of adverse reactions in the observation group was 7.50%, which was lower than22.50% in the control group（P< 0.05）. Conclusion Duloxetine is similar to sertraline in the treatment of senile depression with so-matic symptoms, but the safety of duloxetine is higher than sertraline.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介：陈路，大学本科，主治医师，研究方向：精神科，临床心理科 通信作者：陈路，E-mail：151450386@qq.com
更新日期/Last Update: 2019-08-28