|本期目录/Table of Contents|

[1]陈皓,姚思宇,郑博文,等.RAS系统新通路ACE2—Ang1—7—Mas轴与心血管疾病的研究进展[J].慢性病学杂志,2019,20(08):1154-1158.
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RAS系统新通路ACE2—Ang1—7—Mas轴与心血管疾病的研究进展(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
20
期数:
2019年08期
页码:
1154-1158
栏目:
综 述
出版日期:
2019-07-28

文章信息/Info

Title:
-
作者:
陈皓; 姚思宇; 郑博文; 方晓明; 潘珍红; 黄宇玲; 王志军
华北理工大学附属医院心内科，河北 唐山 063000
Author(s):
-
关键词:
肾素血管紧张素系统; 心血管疾病; 心力衰竭; 血管紧张素转换酶2; 血管紧张素1-7; Mas
Keywords:
-
分类号:
R363.2
DOI:
-
摘要:
肾素血管紧张素系统（RAS）是人体内重要的神经内分泌系统，其中经典的血管紧张素转换酶（angio-tensin-convertingenzyme，ACE）-血管紧张素II（AngII）-血管紧张素II 1型受体（AT1R）轴在心血管疾病 的发生发展，尤其在心力衰竭启动与恶化过程中起着重要作用。随着研究的深入，血管紧张素转换酶2（ACE2）-血管紧张素1-7（Ang1-7）-Mas轴作为反向调节RAS的新支路成为研究热点，Ang1-7与Mas受体结合后发 挥血管舒张、抗心血管重构效应，并具有抗炎、抗纤维化、抗氧化应激、抑制粥样斑块形成、抗血栓形成等作 用。本文结合国内外相关文献就RAS系统新通路ACE2-Ang1-7-Mas轴与心血管疾病的研究进展做一综述， 旨在为延缓心力衰竭发展，改善患者预后，提高生存质量提供新思路。
Abstract:
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参考文献/References:

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备注/Memo

备注/Memo:
基金项目：河北省教育厅课题（ZD2016159） 作者简介：陈皓，硕士研究生，住院医师，研究方向：心 血管内科 通信作者：王志军，E-mail：wzj300@163.com
更新日期/Last Update: 2019-07-28