|本期目录/Table of Contents|

[1]钟伟建,周舸.雾化吸入糖皮质激素治疗慢性阻塞性肺疾病急性加重期的疗效和安全性[J].慢性病学杂志,2019,20(08):1137-1139.
　ZHONGWei-jian,ZHOUGe.Efficacy and safety of inhaled corticosteroid in the treatment of acute exacerbation of chronic obstructive pulmonary disease[J].,2019,20(08):1137-1139.
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雾化吸入糖皮质激素治疗慢性阻塞性肺疾病急性加重期的疗效和安全性(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
20
期数:
2019年08期
页码:
1137-1139
栏目:
论　著
出版日期:
2019-07-28

文章信息/Info

Title:
Efficacy and safety of inhaled corticosteroid in the treatment of acute exacerbation of chronic obstructive pulmonary disease
作者:
钟伟建; 周舸
东莞市麻涌医院内二科，广东 东莞 523100
Author(s):
ZHONGWei-jian; ZHOUGe
Departmentof InternalMedicine,DongguanCity,Guangdong Province,Dongguan523100,China Correspondingauthor: ZHONGWei-jian,E-mail:tsb13654288791@163.com
关键词:
慢性阻塞性肺疾病; 急性加重期; 糖皮质激素; 雾化吸入; 不良反应
Keywords:
Chronic obstructive pulmonary disease;  Acute exacerbation;  Glucocorticoid;  Atomization inha-lation;  Adverse reactions
分类号:
R563.9
DOI:
-
摘要:
目的 探讨雾化吸入糖皮质激素治疗慢性阻塞性肺疾病急性加重期的疗效和安全性，为临床治疗提供参 考。方法 选取2018年1—12月东莞市麻涌医院收治的100例慢性阻塞性肺疾病急性加重期患者，随机分为观 察组和对照组，各50例。对照组采取甲基泼尼松龙针剂静脉滴注治疗，观察组采取布地奈德混悬液雾化吸入治 疗，比较两组肺功能、不良反应发生情况及临床疗效。结果 观察组FEV1占预计值百分比、FEV1/FVC及治 疗总有效率均高于对照组，差异有统计学意义（P<0.05）；观察组不良反应总发生率低于对照组，差异有统计学 意义（P<0.05）。结论 慢性阻塞性肺疾病急性加重期患者采取糖皮质激素雾化吸入治疗可有效改善患者肺功 能，降低不良反应发生率，提高药物使用安全性及临床疗效。
Abstract:
Objective To investigate the efficacy and safety of inhaled glucocorticoid in the treatment of acute exacerbation of chronic obstructive pulmonary disease（COPD）. Methods From January to December2018, 100 patients with acute exacerbation of COPD were randomly divided into observation group and control group. The control group was treated by intravenous injection of methylprednisolone, and the observation group was treated by budesonide suspension atomization inhalation. The pulmonary function, adverse reactions and clinical efficacy were compared between the two groups. Results The predicted value of FEV1%, FEV1/FVC and total effective rate of treatment in the observation group were higher than those in the control group, and the differences were statistically significant（P< 0.05）. The total incidence of nausea and vomiting, dyspnea, oral discomfort, upper abdomen discom-fort, dysphonia and palpitation in the observation group was significantly lower than that in the control group（P<0.05）. Conclusion The aerosol inhalation of glucocorticoid in patients with acute exacerba-tion of COPD can effectively improve the pulmonary function, reduce the incidence of adverse reac-tions, improve the safety of drug use and clinical efficacy.

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备注/Memo

备注/Memo:
作者简介：钟伟建，本科，主治医师，研究方向：呼吸科 通信作者：钟伟建，E-mail：tsb13654288791@163.com
更新日期/Last Update: 2019-07-28