|本期目录/Table of Contents|

[1]袁平,张小鸿,王家兴,等.血清miR-135b在结直肠癌中的表达及临床意义[J].慢性病学杂志,2019,20(08):1121-1124.
　YUANPing *,ZHANGXiao-hong,WANGJia-xing,et al.Expression and clinical significance of serum miR-135b in colorectal cancer[J].,2019,20(08):1121-1124.
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血清miR-135b在结直肠癌中的表达及临床意义(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
20
期数:
2019年08期
页码:
1121-1124
栏目:
论　著
出版日期:
2019-07-28

文章信息/Info

Title:
Expression and clinical significance of serum miR-135b in colorectal cancer
作者:
袁平1; 2; 张小鸿1; 2; 王家兴3; 江丽3
1.福建省疾病预防控制中心实验室质量管理科，福州 350001； 2.福建医科大学公共卫生学院教学基地，福州 350108； 3.福建医科大学附属第一医院，福州 350001
Author(s):
YUANPing * ; ZHANGXiao-hong; WANGJia-xing; JIANGLi
*Fujian CenterforDisease ControlandPrevention,Fuzhou350001,China Correspondingauthor:YUANPing,E-mail:441777195@qq.com
关键词:
血清; miR-135b; 结直肠癌; 早期筛查
Keywords:
Serum;  miR-135b;  Colorectal cancer;  Early screening
分类号:
R735.34
DOI:
-
摘要:
的 探讨血清miR-135b在结直肠癌中的表达及临床意义，为结直肠癌（CRC）发生发展提供诊断依 据。方法 选取2016年7月—2017年7月福建医科大学附属第一医院及协和医院收治的46例结直肠癌确诊患者 作为观察组，另选取46名健康人群作为对照组。观察并比较两组血清miR-135b表达水平[中位数M（四分位 数，IQR）]，采用logistic回归模型分析miR-135b表达与结直肠癌临床病理参数的关系。结果 观察组miR-135b表达量为11.60（3.14~109.65），高于对照组的9.84（5.12~28.06），差异有统计学意义（P<0.05）。miR-135b表达量与淋巴结转移、Dukes分期密切相关（P<0.05）。结论 血清miR-135b高表达与结直肠癌的发生、 恶性程度及淋巴结转移相关，可能作为结直肠癌早期筛查及是否侵袭转移的生物学指标。
Abstract:
Objective To investigate expression and the clinical significance of serum miR-135b in colorectal cancer. Methods The expression of miR-135b in serum of 46 pairs of colorectal cancer patients and healthy controls with matched at 1∶1 was detected by quantitative real-time polymerase chain reaction（qRT-PCR）. The relationship between miR-135b and clinical pathology of colorectal cancer was analyzed by logistic regression. Results The relative expression of miR-135b [M（IQR）] in the serum of colorectal cancer patients [11.60（3.14-109.65）] was higher than that of the healthy controls [9.84（5.12-28.06）], P<0.05. The logistic regression analysis showed that the high expres-sion of miR-135b was correlated with lymph node metastasis and Dukes stage in colorectal cancer pa-tients（P<0.05）. Conclusion The high expression of miR-135b was closely related to the occur-rence, development, invasion and metastasis of colorectal cancer. miR-135b might be used as a biolog-ical indicator for the early screening and the invasion and metastasis of colorectal cancer.

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备注/Memo

备注/Memo:
基金项目：福建省卫生健康委中青年骨干人才培养项目 （2015-ZQN-JC-9）；福建省卫生计生青年科 研课题（2018-1-23） 作者简介：袁平，硕士，副主任医师，研究方向：肿瘤分 子流行病学 通信作者：袁平，E-mail：441777195@qq.com.
更新日期/Last Update: 2019-07-28