«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:

20

期数:

2019年07期

页码:

980-983

栏目:

论　著

出版日期:

2019-07-28

文章信息/Info

Title:

Effect of Huaiqihuang Granule in the treatment of children with asthma and its effect on the immune indicators

作者:

肖华志

山东荣成市妇幼保健院，山东 荣成 264300

Author(s):

XIAOHua-zhi

RongchengMaternal andChild HealthCareHospitalofShandong Province,Rongcheng,Shandong264300,China Correspondingauthor: XIAOHua-zhi,E-mail:Xiaohuazhi303302@163.com

关键词:

槐杞黄颗粒; 沙美特罗替卡松粉吸入剂; 孟鲁司特钠; 免疫指标; 肺功能

Keywords:

Huaiqihuang Granule;  Salmeterol and ticasone powder inhalation;  Montelukast sodium;  Im-mune indicators;  Lung function

分类号:

R725.6

DOI:

-

摘要:

目的 探讨槐杞黄颗粒联合西药治疗哮喘的临床疗效，及对各项免疫指标的影响，为临床治疗提供参 考。方法 选取山东荣成市妇幼保健院2017年1—12月收治的100例哮喘患儿，随机分为观察组与对照组，每 组50例。对照组给予舒利迭联合孟鲁司特钠治疗，观察组在对照组基础上给予槐杞黄颗粒治疗，两组均持续 治疗4周。治疗前后，观察并比较两组中医证候积分、临床疗效、免疫功能指标水平[白细胞介素4（IL-4）、白 细胞介素4（IL-8）、γ-干扰素（IFN-γ）]、肺功能指标[用力肺活量（FVC）、第1秒用力呼气容积（FEV1）、 FEV1/FVC]，统计两组不良反应发生情况。结果 治疗前，两组中医证候积分比较，差异均无统计学意义 （P>0.05）；治疗后，观察组日间证候积分与夜间证候积分均低于本组治疗前和同期对照组，差异有统计学意义 （P<0.05）。观察组总有效率为98.0%，高于对照组的84.0%，差异有统计学意义（P<0.05）。治疗前，两组IL-4、IL-8和IFN-γ水平比较，差异均无统计学意义（P>0.05）；治疗后，两组IL-4、IL-8水平低于本组治疗前 和同期对照组，IFN-γ水平高于本组治疗前和同期对照组，差异有统计学意义（P<0.05）。治疗前，两组FVC、 FEV1及FEV1/FVC水平比较，差异均无统计学意义（P>0.05）；治疗后，观察组FVC、FEV1及FEV1/ FVC水平低于本组治疗前和同期对照组，差异有统计学意义（P<0.05）。两组均无严重不良反应发生。结论 槐杞黄颗粒联合西药治疗小儿哮喘能显著提高临床疗效，改善免疫功能指标、证候积分及改善肺功能。

Abstract:

bjective To discuss the effect of Huaiqihuang Granule combined with western medicine in the treatment ofchildren with asthmaand its effect on the immune indicators. Methods Totally100 children with asthma in Rongcheng Maternal and Child Health Care Hospital from January to Decem-ber 2017 were randomly collected and divided into observation group and control group,50 cases in each group.The control group was treated with salmeterol and montelukast sodium. On the basis of the control group, the observation group was treated with Huaiqihuang Granule. The clinical efficacy, pul-monary function index, serum inflammatory factor levels and syndrome score of the two groups were compared before and after treatment. Results Before treatment, there was no significant difference in traditional Chinese medicine （TCM）syndrome scores between the two groups（P>0.05）, but after treatment, the daytime syndrome scores and night syndrome scores in the observation group were sig-nificantly lower than those before treatment and those in the control group（P<0.05）. The total effec-tive rate in the observation group was 98.0%, which was significantly higher than that in the controlgroup （84.0%）（P<0.05）. Before treatment, there was no significant difference in the levels of IL-4, IL-8 and IFN-γ between the two groups, but after treatment, the levels of IL-4, IL-8 in the observation group were lower than those before treatment and those in the control group, and the level of IFN-γ in the observation group was significantly higher than that before treatment and that in the control group（P<0.05）. Before treatment, there was no significant difference in the levels of FVC, FEV1 and FEV1/FVC between the two groups, but the levels of FVC, FEV1 and FEV1/FVC in the observation group were significantly lower than those before treatment and those in the control group （P<0.05）. No serious adverse reactions occurred in both groups. Conclusion Huaiqihuang Granule combined with western medicine in the treatment of infantile asthma can significantly improve the clini-cal efficacy, immune function, syndrome scores, and lung function.

参考文献/References:

[1] Ichinose M, Sugiura H, Nagase H, et al. Japanese guide-lines for adult asthma 2017 [J]. Allergol Int, 2017,66(2): 163-189.
[2] 全国儿科哮喘协作组,中国疾病预防控制中心环境与健康相关产 品安全所.第三次中国城市儿童哮喘流行病学调查[J].中华儿科 杂志,2013,51(10):729-735.
[3] 梁东阁,李会娟,黄晗.槐杞黄颗粒对喘息性支气管炎患儿免疫功 能影响分析[J].药品评价,2018,15(11):21-23.
[4] 单丽沈,尚云晓,李淼,等.槐杞黄颗粒佐治肺炎支原体肺炎患儿 的多中心随机对照临床研究[J].国际儿科学杂志,2018,45(1): 53-57,72.
[5] 中华医学会儿科学分会呼吸学组《中华儿科杂志》编辑委员会.儿 童支气管哮喘诊断与防治指南（2016年版）[J].中华儿科杂志, 2016,54(3):167-181.
[6] 蒋成,储红梅,曹雪晴.布地奈德联合槐杞黄合理对哮喘患儿肺功 能和免疫功能的影响[J].云南中医学院学报,2018,41(2):30-33.
[7] 王彩云,连宁芳,王碧瑛,等.重症支气管哮喘患者CD4T淋巴细胞 免疫功能分析[J].免疫学杂志,2019,35(2):157-162.
[8] 刘永传.孟鲁司特治疗支气管哮喘的用药效果及对免疫状态的影 响分析[J].中国医药指南,2019,17(6):22-23.
[9] 孙晓慧.匹多莫德辅助应用对小儿支气管哮喘肺功能及免疫功能 的影响[J].安徽医药,2019,23(2):364-367.
[10] 鲁玉敏.支气管哮喘急性发作期儿童25-羟维生素D3水平与细胞 免疫功能的关系[J].中国妇幼保健,2019,34(4):843-845.
[11] 叶娟.信必可都保联合噻托溴铵治疗对COPD合并支气管哮喘患 者肺功能、免疫功能及气道阻力的影响[J].标记免疫分析与临床, 2019,26(2):264-268,289.
[12] 刘爽,米继强,张多,等.槐杞黄颗粒调节“哮喘苗期”小儿体液免疫 的临床研究[J].中国社区医师,2018,34(34):112-113.
[13] 刘爽,米继强,王嘉欣,等.槐杞黄颗粒调节哮喘患儿体液免疫机 理初探[J].中国社区医师,2018,34(33):20-21.
[14] 岳淑娜.布地奈德混悬液雾化吸入联合槐杞黄颗粒治疗小儿支气 管哮喘急性发作的效果[J].河南医学研究,2019,28(3):478-479.

备注/Memo

备注/Memo:

作者简介：肖华志，大学本科，副主任医师，研究方向：儿科呼吸 通信作者：肖华志，E-mail：Xiaohuazhi303302@163.com

常用功能

更新日期/Last Update: 2019-07-28