|本期目录/Table of Contents|

[1]张晓峰,陈文,张健,等.急性发作期哮喘患者血小板参数的变化及其临床意义[J].慢性病学杂志,2019,20(07):972-975.
　ZHANGXiao-feng,CHENWen,ZHANGJian,et al.Platelet Parameters in Patients with Bronchial Asthma in Acute Exacerbation[J].,2019,20(07):972-975.
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急性发作期哮喘患者血小板参数的变化及其临床意义(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
20
期数:
2019年07期
页码:
972-975
栏目:
论　著
出版日期:
2019-07-28

文章信息/Info

Title:
Platelet Parameters in Patients with Bronchial Asthma in Acute Exacerbation
作者:
张晓峰; 陈文; 张健; 张佳倩; 崔玉宝
无锡市人民医院医学检验科，江苏 无锡 214023
Author(s):
ZHANGXiao-feng; CHENWen; ZHANGJian; ZHANGJia-qian; CUIYu-bao
DepartmentofMedical Laboratory,Wuxi People'sHospital,Affiliated toNanjingMedicalUniversity,Jiangsu214023,China Correspondingauthor:CUIYu-bao,E-mail：ybcui1975@hotmail.com
关键词:
血小板参数; 支气管哮喘; 急性发作; 诊断; 受试者工作特征曲线
Keywords:
Platelet parameters;  Bronchial asthma;  Acute exacerbation;  Diagnosis;  Receiver operating characteristic curve
分类号:
R541.1
DOI:
-
摘要:
目的 了解支气管哮喘（简称哮喘）急性发作时血小板参数的变化及临床意义。方法 以无锡市人民医 院收治的356例急性发作期哮喘患者为病例组、1481名体检合格者为对照组，比较两组研究对象的外周血血小板 计数（PLT）、平均血小板体积（MPV）、血小板压积（PCT）、血小板分布宽度（PDW）、血小板淋巴细胞比值 （PLR）的检测结果。结果 病例组PLT、MPV、PCT、PLR高于对照组，PDW低于对照组，差异均有统计 学意义（P<0.05）。病例组中，哮喘合并肺部感染者的MPV和PCT水平均低于单纯哮喘患者，差异有统计学意 义（P<0.05）。所有血小板参数诊断哮喘急性发作的受试者工作特征曲线下面积（AUC）均有统计学意义（P< 0.05），其中，PDW的AUC最高为0.870；在Cutoff值下，灵敏度和特异度分别为0.983和0.803。MPV和PCT 诊断哮喘急性发作合并肺部感染的AUC均有统计学意义（P<0.05），分别为0.766和0.695；在Cutoff值下，灵 敏度和特异度分别为0.742、0.850和0.714、0.500。结论 哮喘急性发作患者血小板参数均异常，合并肺部感 染可使MPV、PCT等部分参数下降，建议将PDW、MPV、PCT用于哮喘急性发作的预警指标。
Abstract:
Objective To analyze platelet parameters in bronchial asthma in acute exacerbation and to provide clinical basis for its clinical diagnosis and treatments. Methods 356 patients with bronchial asthma in acute exacerbation were involved as the case group, and 1481 healthy individuals receiving physical examinations were treated as the control group. The platelet count（PLT）, the mean platelet volume（MPV）, the platelet hematocrit（PCT）, the platelet distribution width（PDW）, the ratio of platelet to lymphocyte（PLR）in the peripheral blood were detected and compared between the two groups. Results The levels of PLT, MPV, PCT and PLR in the case group were higher than those in the control group, and the level of PDW was lower than that in the control group, all of which were statistically significant（P<0.05）. Among the case group, the levels of MPV and PCT of the patients with bronchial asthma complicated with pulmonary infections were lower than those in pa-tients with simple bronchial asthma （without pulmonary infections）with significant difference（P< 0.05）. The areas under the receiver operating characteristic curves （AUC）of each platelet parameter had statistical significance in the diagnosis of acute exacerbation of bronchial asthma（P<0.05）. Among them, the AUC of PDW was the highest（0.870）. Under the Cutoff values, the sensitivity and speci-ficity were 0.983 and 0.803, respectively. The AUC of MPV and PCR in the diagnosis of acute exac-erbation of bronchial asthma complicated with pulmonary infection were 0.766 and 0.695, respectively（P<0.05）. Under the Cutoff values, the sensitivities and specificities were 0.742, 0.850 and 0.714, 0.500, respectively. Conclusions The patients with bronchial asthma in acute exacerbation may show abnormal platelet parameters, and MPV and PCT may decrease in those cases with pulmonary infec-tions. In brief, the PDW, MPV and PCR may serve as prediction indicators for bronchial asthma in acute exacerbation.

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备注/Memo

备注/Memo:
基金项目：江苏省重点研发计划（BE2018627），无锡市卫计委重大课题（Z201701） 作者简介：张晓峰，本科，副主任技师，主要从事临床检验诊断学工作 通信作者：崔玉宝，E-mail：ybcui1975@hotmail.com
更新日期/Last Update: 2019-07-28