|本期目录/Table of Contents|

[1]马冉冉,徐晓玲.亲属活体肾移植受者卡氏肺孢子菌肺炎相关危险因素分析[J].慢性病学杂志,2019,20(03):326-329.
　MARan-ran,XUXiao-ling.Related risk factors for pneumocystis pneumonia in related living kidney transplant recipients[J].,2019,20(03):326-329.
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亲属活体肾移植受者卡氏肺孢子菌肺炎相关危险因素分析(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
20
期数:
2019年03期
页码:
326-329
栏目:
论　著
出版日期:
2019-04-10

文章信息/Info

Title:
Related risk factors for pneumocystis pneumonia in related living kidney transplant recipients
作者:
马冉冉; 徐晓玲
安徽医科大学附属省立医院呼吸科，合肥 230001
Author(s):
MARan-ran; XUXiao-ling
DepartmentofRespiratory,AnhuiProvincialHospitalAffiliated toAnhuiMedicalUniversity,Hefei230001,China Correspondingauthor:XUXiao-ling,E-mail:xxlahh08@163.com
关键词:
亲属活体肾移植; 卡氏肺孢子菌肺炎; 危险因素
Keywords:
Living kidney transplant of relatives;  Pneumocystis pneumonia;  Risk factors
分类号:
R563.1；R617
DOI:
-
摘要:
目的 探讨亲属活体肾移植受者卡氏肺孢子菌肺炎（PCP）的相关危险因素，以期早期预防及识别 PCP。方法 采用回顾性研究，在安徽省立医院病案室收集从2010年8月—2018年8月36例亲属活体肾移植受 者发生PCP的患者，将其纳入PCP组，其中病原学确诊为11例，临床诊断有25例。同时收集同期住院的亲属活 体肾移植受者未发生PCP的患者共49例，纳为非PCP组。收集PCP组与非PCP组的供者年龄、受体性别及年 龄、肾移植前透析时间、有无巨细胞病毒感染、从移植到发生PCP或者肺部其他感染时间、中性粒细胞、淋巴细 胞、发生PCP或肺部其他感染时钙离子（Ca）浓度、肌酐、有无糖尿病、多囊肾、有无肾性高血压及有无排斥 反应等指标。结果 单因素分析发现淋巴细胞、血清Ca均是影响亲属活体肾移植受者术后发生PCP的危险因素 （P<0.05），且多因素分析发现淋巴细胞和Ca是影响PCP发生的独立因素（P<0.05）。结论 在亲属活体肾移植 受者中，淋巴细胞≤0.97×10 9 /L，Ca>2.305mmol/L是预测其发生PCP的有效指标。
Abstract:
Objective To study the risk factors associated with pneumocystis pneumonia（PCP）in liv-ing kidney transplant recipients so as to prevent and identify PCP early. Methods A retrospective study was conducted to collect 36 cases of PCP infection in living related kidney recipients who were treated in Anhui Provincial Hospital from August 2010 to August 2018. Among them, 11 cases were confirmed by etiology, and 25 cases were clinically diagnosed. A total of 49 cases not infected PCP were collected as non-PCP group. Donor age and recipient gender and age, dialysis time before kid-ney transplantation, cytomegalovirus（CMV）infection, time from transplantation to PCP infection, neu-trophils and lymphocytes, serum calcium concentration during PCP infection, creatinine, diabetes, hy-pertensive nephropathy, combined rejection reaction between the two groups were compared. Results The result of univariate analysis showed that there were significant differences in lymphocyte and Ca level between PCP group and non-PCP group （P<0.05）. The result of multifactors analysis showed that lymphocyte and Ca level were the independent factors of PCP（P<0.05）.Conclusion In the re-lated living renal transplant recipients, lymphocyte≤0.97×10 9 /L and Ca>2.305 mmol/L are the effective indicators for the prediction of PCP.

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备注/Memo

备注/Memo:
基金项目：安徽省自然科学基金项目（1608085MH216） 作者简介：马冉冉，硕士研究生，研究方向：呼吸系统疾病 通信作者：徐晓玲，E-mail：xxlahh08@163.com
更新日期/Last Update: 2019-03-28