|本期目录/Table of Contents|

[1]邓灿,林巧威,丁勇泉,等.手术去势联合比卡鲁胺片治疗高龄晚期前列腺癌患者的疗效及安全性分析[J].慢性病学杂志,2019,20(02):181-183.
　DENG Can,LIN Qiao-wei,DING Yong-quan,et al.Efficacy and safety of surgical castration combined with bicalutamide in patients with advanced prostate cancer[J].,2019,20(02):181-183.
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手术去势联合比卡鲁胺片治疗高龄晚期前列腺癌患者的疗效及安全性分析(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
20
期数:
2019年02期
页码:
181-183
栏目:
论　著
出版日期:
2019-03-28

文章信息/Info

Title:
Efficacy and safety of surgical castration combined with bicalutamide in patients with advanced prostate cancer
作者:
邓灿;  林巧威;  丁勇泉;  李汉强;  邱峻辉
高州市人民医院泌尿外科一区，广东高州525200
Author(s):
DENG Can;  LIN Qiao-wei;  DING Yong-quan;  LI Han-qiang;  QIU Jun-hui
Department of Urology, Gaozhou People's Hospital, Gaozhou, Guangdong 525200, China Corresponding author: DENG Can, E-mail: dengcan2012@126.com
关键词:
前列腺癌; 手术去势; 比卡鲁胺片; 不良反应; 前列腺特异性抗原
Keywords:
Prostate cancer;  Surgical castration;  Bicalutamide tablets;  Adverse reactions;  Prostate specific antigen
分类号:
R737.25
DOI:
-
摘要:
目的探讨手术去势联合比卡鲁胺片治疗高龄晚期前列腺癌患者的临床疗效及安全性分析，为临床治疗 提供参考。方法纳入高州市人民医院2013 年1月至2017 年8月收治的前列腺癌患者共60例，随机分为对照组 和观察组，各30例。对照组患者采用双侧睾丸切除术，观察组患者在对照组基础上联合服用比卡鲁胺片治疗，治 疗1个月后观察两组患者的临床疗效，对患者进行随访，观察不良反应发生情况。结果对照组和观察组治疗的 总有效率分别为66.67%和90.00%，差异有统计学意义（P<0.05）。对照组和观察组治疗期间的不良反应发生率 分别为60.00%和23.33%，差异有统计学意义（P<0.05）。治疗前，两组患者的前列腺特异性抗原（PSA） 水平 比较，差异无统计学意义（P>0.05）；治疗1、6、12个月后，观察组PSA 水平较对照组明显降低，差异均有统计 学意义（P<0.05）。结论手术去势联合比卡鲁胺片治疗高龄晚期前列腺癌患者可有效的改善临床疗效，降低不 良反应发生率，并降低患者PSA 水平。
Abstract:
Objective To observe the efficacy and safety of surgical castration combined with bicalutamide in patients with advanced prostate cancer. Methods A total of 60 patients with prostate cancer from January 2013 to August 2017 were randomly divided into the control group and the observation group, 30 patients in each group. All patients underwent bilateral orchiectomy, and the observation group was given bicalutamide tablets.After 1 month of treatment, the clinical efficacy of the two groups were observed, and patients were followed up to observe the occurrence of adverse reactions. Results The total effective rate of the control group and the observation group were 66.67% and 90.00%, respectively. The total effective rate of the observation group was higher than that of the control group （P<0.05） . The incidence of adverse reactions in the control group and the observation group were 60.00% and 23.33% , respectively. The incidence of adverse reactions in the observation group was lower than that in the control group （P<0.05） . Before treatment, there was no significant difference in the prostate specific antigen （PSA） between the two groups （P>0.05） . After 1, 6, 12 months of treatment, the PSA levels of the observation group were lower thant those of the control group （P<0.05） . Conclusion Surgical castration combined with bicalutamide tablets can effectively improve the clinical efficacy of patients with advanced prostate cancer, and the incidence of adverse reactions is low.

参考文献/References:


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备注/Memo

备注/Memo:
作者简介：邓灿，大学本科，主治医师，研究方向：泌尿外科 通信作者：邓灿，E-mail：837333187@qq.com
更新日期/Last Update: 2019-02-28