|本期目录/Table of Contents|

[1]周超,付翠平.450例结肠息肉临床特点及癌变相关因素分析[J].慢性病学杂志,2019,20(12):1803-1806.
　ZHOUChao,FUCui-ping.Analysis of clinical characteristics and carcinogenesis related factors in450cases with colonic polyps[J].,2019,20(12):1803-1806.
点击复制

450例结肠息肉临床特点及癌变相关因素分析

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
20
期数:
2019年12期
页码:
1803-1806
栏目:
论　著
出版日期:
2019-12-28

文章信息/Info

Title:
Analysis of clinical characteristics and carcinogenesis related factors in450cases with colonic polyps
作者:
周超; 付翠平
兖矿新里程总医院消化内科，山东 邹城 273500
Author(s):
ZHOUChao; FUCui-ping
DepartmentofGastroenterology, YankuangNewJourneyGeneral Hospital,Zoucheng273500,Shandong, China Correspondingauthor:ZHOUChao,E-mail:zhouchao2007001@163.com
关键词:
结肠息肉; 临床特点; 癌变; 相关因素
Keywords:
Colonic polyp;  Clinical characteristics;  Carcinogenesis;  Related factors
分类号:
R574.62
DOI:
-
摘要:
目的 总结结肠息肉患者的临床及病理组织学特点，探讨相关癌变因素。方法 回顾性分析450例结肠 息肉患者的临床资料，根据病理特点分为非腺瘤性息肉组（142例）及腺瘤性息肉组（308例），腺瘤性息肉组根 据患者上皮内瘤变程度分为低级别瘤变组（237例）及高级别瘤变组（71例），对各组间年龄、性别及息肉数目、 直径、分布位置、山田分型、表面黏膜情况、分叶、临床表现进行统计分析。结果 结肠息肉患者中腺瘤发生 率为68.44%，腺瘤性息肉中高级别瘤变组与低级别瘤变组在消化道出血症状差异有统计学意义（P<0.05），腺瘤 性息肉和非腺瘤性息肉组在性别、分布部位差异无统计学意义（P>0.05）；在年龄、息肉数目、息肉直径、山田 分型、表面黏膜形态、分叶情况方面差异有统计学意义（P<0.05），高级别瘤变组与低级别瘤变组在息肉直径、 山田分型、表面黏膜形态、分叶情况方面差异有统计学意义（P<0.05）。结论 结肠息肉的临床特点中高级别瘤 变患者更容易出现消化道出血，息肉直径大于1 cm、山田Ⅲ型及Ⅳ型、表面糜烂或溃疡、分叶者高级别上皮内 瘤变发生率增高。
Abstract:
objective To summarize the clinical and histopathological characteristics of patients with co-lonic polyps and to explore the related carcinogenesis factors of the disease. Methods A total of450 patients with colonic polyps were divided into non-adenomatous polyp group（n=142）and adenomatous polyp group（n=308）according to their pathological characteristics by retrospective analysis. The adeno-matous polyp group was divided into low-grade group（n=237）and high-grade groups（n=71）accord-ing to the degree of intraepithelial neoplasia. The age, sex, number of polyps, diameter, distribution, Yamada classification, surface mucosa, lobulation and clinical manifestations were statistically analyzed. Results The incidence of adenoma in patients with colonic polyps was68.44%. There was a signifi-cant difference in gastrointestinal bleeding symptoms between high-grade adenomatous polyps and low-grade adenomatous polyps（P<0.05）. There was no significant difference in sex and distribution be-tween adenomatous polyp group and non-adenomatous polyp group（P>0.05）. There were significant differences in age, number of polyps, the diameter of polyps, Yamada classification, surface mucosa morphology and lobulation between adenomatous polyp group and non-adenomatous polyp group（P< 0.05）. There were significant differences in polyp diameter, Yamada classification, surface mucosa morphology and lobulation between the high-grade neoplastic group and low-grade neoplastic group（P< 0.05）. Conclusions The clinical characteristics of colonic polyps are more likely to have gastrointes-tinal bleeding in patients with high-grade tumors, and the incidence of high-grade intraepithelial neopla-sia is higher in patients with polyps larger than 1 cm, Yamada Ⅲand Ⅳ, surface erosion or ulcer and lobulation.

参考文献/References:

[1] Krishn SR, Kaur S, Smith LM,et al. Mucins and associ-ated glycan signatures in colon adenoma- carcinoma se-quence:prospective pathological implication(s) for early diag-nosis of colon cancer [J]. Cancer Lett,2016,374(2):304-314. [2] Lieberman DA, Rex DK, Winawer SJ, et al. Guidelines for colonoscopy surveillance after screening and polypecto-my: a consensus update by the US Multi- Society Task Force on Colorectal Cancer [J]. Gastroenterology,2012,143 (3):844-857. [3] 张玥石,菊芳,中国人群结直肠癌疾病负担分析[J].中华流行病学 杂志,2015,36(7):709-714. [4] Calderwood AH, Lasser KE, Roy HK. Colon adenoma features and their impact on risk of future advanced adeno-mas and colorectal cancer [J]. World J Gastrointest Oncol, 2016,8(12):826-834. [5] Corley DA, Jensen CD, Marks AR, et al. Variation of Adenoma Prevalence by Age, Sex, Race, and Colon Lo-cation in a Large Population: Implications for Screening and Quality Programs [J]. Clin Gastroenterol Hepatol, 2013,11(2):172–180. [6] 樊丽伟,李洵,孟晓明,等.Tat结合蛋白30在结直肠腺瘤及结直肠 癌组织中的表达[J].中华实验外科杂志,2017,34(1):52-54. [7] 黄宁,吴万春.电子结肠镜检查回盲部病变12328例分析[J].中华 消化病与影像杂志(电子版),2014,4(4):161-165. [8] Kim JH, Nam KS, Kwon HJ,et al. Assessment of colon polyp morphology: Is education effective [J]. World J Gas-troenterol, 2017,23(34):6281-6286. [9] 陈平,袁晓琴,谢玲,等.上海市嘉定地区1265例结肠直肠息肉内 镜下诊治临床资料回顾性分析[J].胃肠病学和肝病学杂志,2016, 25(5):524-528.

备注/Memo

备注/Memo:
作者简介：周超，硕士，主治医师，研究方向：胃肠疾病 通信作者：周超，E-mail：zhouchao2007001@163.com
更新日期/Last Update: 2019-12-28