|本期目录/Table of Contents|

[1]邢益祥,谢贞兰,刘晨.Beclin1、p53及Ki-67在宫颈病变中表达及临床意义[J].慢性病学杂志,2019,20(12):1786-1788.
　XINGYi-xiang,XIEZhen-lan,LIUChen.Expression and clinicopathological significance of Beclin1, p53 and Ki-67in cervical lesions[J].,2019,20(12):1786-1788.
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Beclin1、p53及Ki-67在宫颈病变中表达及临床意义

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
20
期数:
2019年12期
页码:
1786-1788
栏目:
论　著
出版日期:
2019-12-28

文章信息/Info

Title:
Expression and clinicopathological significance of Beclin1, p53 and Ki-67in cervical lesions
作者:
邢益祥; 谢贞兰; 刘晨
铜陵市人民医院病理科，安徽 铜陵 244009
Author(s):
XINGYi-xiang; XIEZhen-lan; LIUChen
Departmentof Pathology, Tongling People’sHospital,Tongling244009,Anhui,China Correspondinauthor:XINGYi-xiang,E-mail:904601185@qq.com
关键词:
宫颈病变; 宫颈鳞状上皮低级别上皮内病变; 宫颈鳞状细胞癌; Beclin1; p53; Ki-67
Keywords:
Cervical lesions;  Low grade squamous intraepithelial lesion;  Cervical squamous cell carcino-ma;  Beclin1;  p53;  Ki-67
分类号:
R737.33
DOI:
-
摘要:
目的 探讨Beclin1、p53及Ki-67在宫颈病变中的表达及临床意义。方法 回顾性分析铜陵市人民医 院2018年5月—2019年3月的131例宫颈病变组织切片，宫颈鳞状细胞癌（SCC）41例、宫颈鳞状上皮高级别上 皮内病变（HSIL）35例和宫颈鳞状上皮低级别上皮内病变（LSIL）35例、正常宫颈组织（NC）20例。检测并 比较各组间Beclin1、p53、Ki-67表达情况。结果 在NC组、LSIL组、HSIL组和SCC组，Beclin1阳性率 分别为95.00%、82.86%、62.86%和31.71%；p53阳性率分别为5.00%、14.29%、40.00%和56.10%；Ki-67阳性 率分别为5.00%、77.14%、91.43%和92.68%。NC组与SCC、HSIL组间Beclin1、p53和Ki-67表达比较，差 异有统计学意义（P<0.05）；NC组与LSIL组Beclin1和p53表达比较，差异无统计学意义（P>0.05）；NC组与 LSIL组间Ki-67表达比较，差异有统计学意义（P<0.05）；LSIL组与SCC、HSIL三组间Beclin1、p53和Ki-67表达比较，差异有统计学意义（P<0.05）；LSIL组与SCC组间Beclin1、p53 和Ki-67表达比较，差异有统 计学意义（P<0.05）；HSIL组与SCC组Beclin1表达比较，差异有统计学意义（P<0.05）。HSIL组与SCC组 p53和Ki-67表达比较，差异无统计学意义（P>0.05）。结论 联合检测Beclin1、p53及Ki-67对宫颈病变中 NC与SCC、HSIL之间，以及LSIL与SCC、HSIL之间的鉴别诊断有一定指导作用，对NC与LSIL之间鉴别诊 断作用有限。
Abstract:
Objective To investigate the expression and prognostic significance of Beclin1, p53 and Ki-67 in cervical lesions. Method Cervical lesion specimens of41 patients with squamous cell carci-noma（SCC group）, 35 high grade squamous intraepithelial lesion（HSIL group）, 35 low grade squamous intraepithelial lesion（LSIL）, and 20 patients with normal cervical tissue（NC group）were collected from May 2018 to March 2019 in Tongling People’s Hospital. Immunohistochemistry was used to observe the expressions of Beclin 1, p53 and Ki-67. Results In NC group, LSIL group, HSIL group and SCC group, the positive rates of Beclin1 were 95.00%,82.86%,62.86% and 31.71%, respectively; the positive rates of p53 were5.00%,14.29%,40.00% and56.10%, respective-ly; the positive rates of Ki-67 were5.00%,77.14%,91.43% and92.68%, respectively. There were significant differences in the expression of Beclin 1, p53 and Ki-67 between NC group and SCC group, HSIL group（P<0.05）. There was no significant difference in the expression of Beclin 1 and p53 between NC group and LSIL group（P>0.05）. There was significant difference in the expressionof Ki-67 between NC group and LSIL group（P<0.05）. There were significant differences in the ex-pression of Beclin 1, p53 and Ki-67 between LSIL group and SCC group, HSIL group（P<0.05）. There were significant differences in the expression of p53 and Ki-67 between LSIL group and SCC group（P<0.05）. There was significant difference in the expression of Belin 1 between HSIL group and SCC group（P<0.05）. There was no significant difference in the expression of p53 and Ki-67 between HSIL group and SCC group（P>0.05）. Conclusion Combined detection of Beclin1 pro-tein, p53 protein and Ki-67 proliferation index plays a guiding role in the differential diagnosis be-tween NC, SCC and HSIL, as well as between LSIL, SCC and HSIL in cervical lesions. The value of differential diagnosis between NC and LSIL is limited.

参考文献/References:

[1] Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013[J]. CA Cancer J Cline, 2013,63(1):11-30. [2] 尤小燕,王雅莉,刘文枝,等.高危型HPV联合行不行检测在宫颈 癌及癌前病变筛查中临床意义[J].实用预防医学,2017,24(8): 986-988. [3] 田君才,杜国亮,张桂霞.人工免疫组化判定结果与灰度值相关性 [J].临床与实验病理学杂志,2010,26(1):112-113. [4] Ding L, Wang S, Wang W,et al. Tanshinone IIA affects autophagy and apoptosis of glioma cells by inhibting phos-phatidylionsitol3-kinase/Akt/mammalian target of rapamy-cin signaling pathway [J]. Pharmacology, 2016,99(1-2):99-102. [5] Li XY, Wang GQ. The correlation between Beclin1、P53 and the malignancy,efficacy and prognosis of lung cancer [J]. Chinese J Microecol, 2010,22(8):714-718. [6] Valente G, Morani F, Nicotra G,et al. Expression and clinical significance of the autophagy proteins Beclin 1 and LC3 in ovarian cancer [J]. Biomed Res Int, 2014,2014(8): 462-658. [7] 张晶,舒丽莎,陈江平,等.Beclin 1、MAP1LC3B和mTOP在宫颈 病变中的表达及临床意义[J].河北北方学院学报,2017,33(6):1-5. [8] 张欣宁,吴海燕,刘永珠,等.Beclin 1和P53在宫颈癌中的表达意 义及其与预后的关系[J].吉林医学,2018,39(7):1206-1208. [9] Yang N, Han F, Cui H,et al. Matrine suppresses prolif-eration and induces apoptosis in human cholangiocarcinoma cells through suppression of JAK2/STAT3 signaling [J]. Pharmacol Rep,2015,67(2):388-393. [10] 马慧,尹利荣,王芳,等.P-JAK2/P-STAT3与突变型P53蛋白 在宫颈病变中的表达及临床意义[J].天津医药,2016,44(2):221-225. [11] 余俐,彭杰青,陈尚武.宫颈上皮内瘤变中P16INK4A和Ki-67的 表达[J].临床与实验病理学杂志,2007,23(6):665-668. [12] 陆卉.p16IN4A、p53、Ki-67及ER在宫颈病变中表达的意义[J]. 实用妇科内分泌杂志,2018,5(19):118-119.

备注/Memo

备注/Memo:
作者简介：邢益祥，硕士，副主任医师，研究方向：乳腺、妇科病理 通信作者：邢益祥，E-mail：904601185@qq.com
更新日期/Last Update: 2019-12-28