|本期目录/Table of Contents|

[1]许锦鸿.原发性高血压患者诊室收缩压变异性与轻度认知功能障碍相关性[J].慢性病学杂志,2019,20(10):1470-1473.
　XUJin-hong.Relationship between visit-to-visit blood pressure variability and mild cognition impairment[J].,2019,20(10):1470-1473.
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原发性高血压患者诊室收缩压变异性与轻度认知功能障碍相关性

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
20
期数:
2019年10期
页码:
1470-1473
栏目:
论　著
出版日期:
2019-10-28

文章信息/Info

Title:
Relationship between visit-to-visit blood pressure variability and mild cognition impairment
作者:
许锦鸿
福建省立医院，福州 350000
Author(s):
XUJin-hong
Departmentof Cardiology,FujianProvincialHospital,Fuzhou350000,China Correspondingauthor:XUJin-hong,E-mail:452034664@qq.com
关键词:
原发性高血压病; 血压变异性; 轻度认知功能障碍; 蒙特利尔认知功能评估
Keywords:
Essential hypertension;  Blood pressure variability;  Mild cognition impairment;  Montreal cogni-tive assessment
分类号:
R544.1
DOI:
-
摘要:
目的 探讨原发性高血压患者诊室血压变异性（VVBPV）与轻度认知功能障碍（MCI）的相关性。 方法 选取福建省立医院收治的100例高血压门诊患者的临床资料，分析患者基本信息[性别、年龄、身高、体 质量、降压方案、体质量指数（BMI）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、 空腹血糖（FPG）、诊室血压]，VVBPV以诊室收缩压标准差（SD）、变异系数（CV）、连续变异（SV）、独立 于均值的变异（VIM）评估，采用蒙特利尔认知评估量表（MoCA）评估患者认知功能水平。结果高-VIM组 年龄高于低-VIM组，钙通道阻滞剂（CCBS）使用率低于低-VIM组，差异均有统计学意义（P<0.05）。两组 性别、是否合并糖尿病、是否吸烟、BMI、TC、TG、LDL-C、FPG、肾素-血管紧张素系统抑制剂（RAS-I） 的使用、β受体阻滞剂的使用、利尿剂的使用、收缩压、舒张压、心率均无显著性差异。SD、SV、CV、VIM与 收缩压的Pearson相关系数分别为0.146、0.151、-0.045、-0.03，但P>0.05，四个变异性指标均独立于收缩压 值。高-VIM组MoCA总分、视空间及执行功能、注意力、延迟回忆均低于低-VIM组，差异有统计学意义 （P<0.05）。校正年龄的影响，上诉指标仍显著低于低-VIM组（P<0.05）。年龄、VIM、使用CCBs均是影响 MoCA的重要因素。结论 VVBPV独立于血压值，且与MCI相关，因此降压治疗不仅是降低血压值，同时也 需关注BPV，争取平稳降压。
Abstract:
Objective To study the relationship between visit- to- visit blood pressure variability （VVBPV）and mild cognition impairment（MCI）. Methods The clinic date of100 hypertensive outpatients of Fujian Provincial Hospital were analyzed. Basic information of patients was analyzed, in-cluding sex, age, height, weight, antihypertensive treatment, body mass index（BMI）, total choles-terol（TC）, triglycerides（TG）, low-density lipoprotein cholesterol（LDL-C）, fasting blood glucose （FPG）and clinic blood pressure（BP）. The standard deviation（SD）, coefficient of variation（CV）, successive variation（SV）and variation independent of mean（VIM）of clinic systolic blood pressure （SBP）were used to assess VVBPV. The Montreal cognitive assessment（MoCA）was used to detect MCI.Results The high-VIM group had higher mean age and lower rate of administered calcium channel blockers（CCBs）than the low-VIM group（P<0.05）. These two groups of patients did not differ significantly in gender, diabetes mellitus, smoking history, BMI, TC, TG, LDL-C, FPG, medications [renin-angiotensin system inhibitor（RAS-I）, β-receptor blocker, diuretic], SBP, diastol-ic blood pressure （DBP）, heart rate（HR）. The Pearson correlation coefficients of SD, SV, CV, VIM with SBP were0.146, 0.151, -0.045, -0.03, respectively（P>0.05）, and they were all inde-pendent of SBP. The high-VIM group had a significantly lower total MoCA score and lower scores on visuoexecutive, attention and recall, before and after adjustment for age. Multiple linear regression analysis showed that age and VIM and administered CCBs were independent factors for MoCA after adjusting for covariates. Conclusions VVBPV, independent of mean BP, was related to MCI. Anti-hypertensive treatment should be targeted not only towards reducing mean BP levels but also to stabi-lizing BPV.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介：许锦鸿，硕士，住院医师，研究方向：高血压 通信作者：许锦鸿，E-mail：452034664@qq.com
更新日期/Last Update: 2019-10-28