|本期目录/Table of Contents|

[1]刘晓红.盐酸美金刚治疗老年帕金森病痴呆的临床疗效及不良反应[J].慢性病学杂志,2019,20(01):36-38.
　LIU Xiao-hong.Clinical efficacy and adverse reactions of memantine hydrochloride on patients with senile Parkinson’s disease dementia[J].,2019,20(01):36-38.
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盐酸美金刚治疗老年帕金森病痴呆的临床疗效及不良反应(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
20
期数:
2019年01期
页码:
36-38
栏目:
论　著
出版日期:
2019-01-30

文章信息/Info

Title:
Clinical efficacy and adverse reactions of memantine hydrochloride on patients with senile Parkinson’s disease dementia
作者:
刘晓红
登封市中医院，河南登封452470
Author(s):
LIU Xiao-hong
Traditional Chinese Medicine of Dengfeng City, Dengfeng, Henan 452470, China Corresponding author: LIU Xiao-hong, E-mail: 13653813225@163.com
关键词:
盐酸美金刚; 老年帕金森病; 痴呆; 不良反应
Keywords:
Memantine hydrochloride;  Senile Parkinson’s disease;  Dementia;  Adverse reaction
分类号:
R742.5
DOI:
-
摘要:
目的探讨盐酸美金刚治疗老年帕金森病痴呆的疗效及不良反应。方法选取2017年1月—2018年1月 登封市中医院60 例就诊的老年帕金森痴呆患者，随机分为观察组和对照组，每组30 例。其中，对照组给予盐酸 多奈哌齐治疗，观察组给予盐酸美金刚治疗，对比两组的蒙特利尔量表评分、治疗总有效率及不良反应发生率。 结果治疗前，两组患者的蒙特利尔认知量表评分比较差异无统计学意义（P＞0.05）；治疗后，观察组的蒙特 利尔认知量表评分（23.78±3.12） 分高于对照组的（20.47±3.45） 分，差异有统计学意义（P＜0.05）。治疗后， 观察组总有效率（93.33%） 高于对照组（73.33%），差异有统计学意义（P＜0.05）。治疗后，观察组的不良反应 发生率（16.67%） 低于对照组（26.67%），差异有统计学意义（P＜0.05）。结论盐酸美金刚治疗老年帕金森 病痴呆的临床疗效显著，可降低不良反应发生率。
Abstract:
Objective To investigate the efficacy and side effects of memantine hydrochloride in the treatment of patients with dementia induced by senile Parkinson’s disease. Methods Totally 60 cases of patients with senile Parkinson dementia who came from Traditional Chinese Medicine of Dengfeng City from January 2017 to January 2018 were randomly divided into the observation group and the control group, 30 cases in each group. The control group was given donepezil hydrochloride. The observation group was given the memantine hydrochloride. The Montreal scale, the total effective rate of treatment and the incidence of adverse reactions were compared between the two groups. Results Before treatment, the Montreal cognitive scale score was not significantly different between the two groups （P>0.05） . After treatment, the Montreal cognitive scale score of the observation group was higher than that of the control group （23.78±3.12 vs. 20.47±3.45, P<0.05） ; the total effective rate of the observation group was higher than that of the control group （93.33% vs. 73.33%, P<0.05） ; the incidence of adverse reactions in the observation group was lower than that in the control group （16.67% vs. 26.67%, P<0.05） . Conclusion Memantine hydrochloride is effective in treating dementia caused by senile Parkinson’s disease and can reduce the incidence of adverse reactions.

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备注/Memo

备注/Memo:
作者简介：刘晓红，大学本科，副主任医师，研究方向：内科 通信作者：刘晓红，E-mail: 13653813225@163.com
更新日期/Last Update: 2019-01-30