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Title:: Comparison of the effect of reaglinide and pyrazine cyclohexylurea on the patients with type 2 diabetes mellitus complicated with arteriosclerosis

作者:: 赖荣昌; 魏九金; 广东省东莞市桥头医院内科，广东东莞523523

Author(s):: LAI Rong-chang; WEI Jiu-jin; Department of internal medicine, Qiaotou Hospital, Dongguan, Guangdong 523523 Corresponding author: LAI Rong-chang, E-mail: LaiRC@163.com

关键词:: 2型糖尿病; 吡磺环己脲; 瑞格列奈; 动脉硬化; 血糖

Keywords:: Type 2 diabetes; Pyrazine cyclohexylurea; Reglienet; Arteriosclerosis; Blood sugar

分类号:: R587.1

DOI:: -

摘要:: 目的探讨瑞格列奈和吡磺环己脲治疗2 型糖尿病合并动脉硬化的临床应用效果。方法选取广东省东莞市桥头医院2016 年1 月—2017 年12 月收治的70 例2 型糖尿病合并动脉硬化患者，按照随机数字法分为观察组和对照组，每组35 例。其中，对照组予以吡磺环己脲治疗，观察组予以瑞格列奈治疗，两组患者均治疗3 个月。比较两组患者空腹血糖水平、餐后2h 血糖水平、C 反应蛋白（CRP）水平、血清氧化型低密度脂蛋白（oxLDL）水平及满意度情况。结果两组患者治疗前空腹血糖、餐后2h 血糖水平比较差异无统计学意义（P＞0.05），治疗后两组患者空腹血糖、餐后2h 血糖水平均显著降低，且观察组显著低于对照组（P＜0.05）。两组患者治疗前 CRP 和oxLDL 水平比较差异无统计学意义（P＞0.05），治疗后两组患者CRP 和oxLDL 水平均显著降低，且观察组显著低于对照组（P＜0.05）。观察组患者满意度（97.14%）显著高于对照组（80.00%），差异有统计学意义（P＜0.05）。结论瑞格列奈治疗2 型糖尿病合并动脉硬化相较于吡磺环己脲治疗可显著控制患者血糖水平，改善动脉粥样硬化病变，且患者具有较高的满意度。

Abstract:: Objective To explore the clinical efficacy of reaglinide and pyrazylium cyclohexylurea in the treatment of type 2 diabetes mellitus complicated with arteriosclerosis. Methods A total of 70 patients with type 2 diabetes complicated with arteriosclerosis came from Qiaotou Hospital in Dongguan city of Guangdong province were selected from January 2016 to December 2017. The subjects were divided into observation group and control group by random number table method, each 35 cases. The control group was treated with pyrazine cyclohexylurea for 3 months, the observation group was treated with reaglinide for 3 months. The fasting blood glucose level, 2 h postprandial blood glucose level, C reactive protein （CRP） level, serum oxidized low- density lipoprotein （oxLDL） level and satisfaction were compared between the two groups. Results There were no statistically significant differences in fasting blood glucose and 2 h postprandial blood glucose levels between the two groups before and after treatment （all P>0.05） . After treatment, fasting blood glucose and 2 h postprandial blood glucose levels of the two groups were significantly reduced, and the observation group was significantly lower than the control group （all P<0.05） . There was no statistically significant difference in the levels of CRP and oxLDL between the two groups before treatment （all P>0.05） . The levels of CRP and ox- LDL were significantly decreased in both groups after treatment, and the observation group was signifi-cantly lower than the control group （all P<0.05） . The satisfaction of patients in the observation group （97.14%） was significantly higher than that of the control group （80.00%）（P<0.05） . Conclusion Reaglinide can significantly control the blood glucose level and improve the atherosclerotic lesions and the satisfaction of patients with type 2 diabetes combined with arteriosclerosis, the effect of which was better than pyrazine cyclohexylurea.

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《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

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