|本期目录/Table of Contents|

[1]王军凯,李丽.幽门螺旋杆菌和慢性胃炎胃黏膜病理变化的相关性研究[J].慢性病学杂志,2018,(9):1151-1153.
　WANG Jun-kai*,LI Li.Correlation between helicobacter pylori and pathological changes of gastric mucosa in patients with chronic gastritis[J].,2018,(9):1151-1153.
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幽门螺旋杆菌和慢性胃炎胃黏膜病理变化的相关性研究(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2018年9期
页码:
1151-1153
栏目:
论　著
出版日期:
2018-09-30

文章信息/Info

Title:
Correlation between helicobacter pylori and pathological changes of gastric mucosa in patients with chronic gastritis
作者:
王军凯1;  李丽2
1. 许昌市中心医院，河南许昌461000；2. 郑州大学医学院，郑州450001
Author(s):
WANG Jun-kai*;  LI Li
*Central Hospital of Xuchang, Xuchang, Henan 461000, China Corresponding author: WANG Jun-kai, E-mail: doctorw16@126.com
关键词:
幽门螺旋杆菌; 慢性胃炎; 胃黏膜; 病理变化; 相关性
Keywords:
Helicobacter pylori;  Chronic gastritis;  Gastric mucosa;  Pathological changes;  Correlation
分类号:
R573.3
DOI:
-
摘要:
目的探讨幽门螺旋杆菌（Hp） 感染和慢性胃炎（CG） 患者胃黏膜病理变化的相互关系，为临床治疗 提供借鉴依据。方法选取2015 年2 月—2017 年2 月许昌市中心医院收治的68 例CG 患者作为观察组，44 例同 期健康体检者为对照组，对两组进行Hp阳性检查，并分析CG 患者炎症程度、萎缩程度和肠化分级不同病理特征 的Hp 感染情况，分析比较Hp 阳性率。结果观察组Hp 阳性率为84.82%，显著高于对照组的38.39%，差异有 统计学意义（P<0.05）；随CG 炎症程度、萎缩程度、肠化分级等不同病理特征的加剧，Hp 阳性率均逐渐升高， 差异有统计学意义（P<0.05）。结论Hp 和CG 胃黏膜患者病理变化有一定相关性，可反映出患者炎症感染程 度、萎缩程度和肠化分级程度。
Abstract:
Objective To investigate correlation between pathological changes of gastric mucosa in patients with helicobacter pylori （Hp） infection and chronic gastritis （CG） in order to provide reference for clinical treatment. Methods Totally 68 patients with CG treated in Xuchang Central Hospital from February 2015 to February 2017 were selected as the observation group, and 112 healthy subjects were enrolled as control group at the same time. Hp positive examinations were performed in two groups and the degrees of inflammation and atrophy and Hp infection in different pathological grades of intestinal metaplasia of CG patients were analyzed. The positive rate of Hp was compared. Results The positive rate of Hp in the observation group was 84.82% , which was significantly higher than 38.39% in the control group, and the difference was statistically significant （P<0.05） . With the increase of different pathological features, such as CG degree of inflammation, extent of atrophy and grading of intestinal metaplasia, the positive rate of Hp was increased gradually and the difference was statistically significant （P<0.05） . Conclusion Hp has a certain correlation with pathological changes of gastric mucosa in patients with CG, which can reflect the degrees of inflammation, atrophy and intestinal metaplasia.

参考文献/References:


[1] 兰春慧,黎博胜,常辉,等. 幽门螺杆菌感染的慢性胃炎与凋亡基 因的相关性研究[J].重庆医学,2014,43(29):3858-3860.
[2] 卫颖秋.幽门螺杆菌感染及胃黏膜病理改变和血清硫氧还蛋白-1 水平的相关性研究[J].现代中西医结合杂志,2014,23(19):2077- 2079.
[3] 甘远,黄方华,王瑞云,等.幽门螺杆菌感染的治疗现状及进展[J]. 海南医学,2016,27(9):1483-1485.
[4] 房静远,刘文忠,李兆申,等.中国慢性胃炎共识意见[J].胃肠病学, 2013,1(18):24-36.
[5] 钟晓琴,周飞,刘丽秋.2型糖尿病、糖尿病肾病患者幽门螺杆菌感 染及胃黏膜病变发病率临床研究[J].中国基层医药,2016,23(21): 3333-3337.
[6] 邵晓红.幽门螺杆菌感染与慢性胃炎患者胃黏膜病理变化的相关 性研究[J].临床和实验医学杂志,2015,14(17):1416-1418.
[7] 霍永利,李佃贵,马小顺.化浊解毒方对幽门螺杆菌相关性萎缩性 胃炎患者胃黏膜病理的影响[J]. 中医杂志,2014,55(16):1383- 1385.
[8] 姜旻亮,朱赛英,张笑. 胃镜活检标本中性粒细胞、淋巴滤泡与幽 门螺杆菌感染的相关性研究[J].中国基层医药,2014,21(7):1033- 1034.
[9] 王妮娟,李静. 上消化道症状与幽门螺杆菌感染及胃癌前疾病的 相关性研究[J].临床和实验医学杂志,2015,10(4):291-294.
[10] 李虹,肖宏伟. 两种三联疗法治疗幽门螺杆菌阳性消化道溃疡的 效果比较[J].中国基层医药,2014,1(16):2535-2536.
[11] 孙新超,秦旭,张德洋,等. 老年患者胃黏膜不同病理形态幽门螺 杆菌感染相关性研究[J]. 中华医院感染学杂志,2016,26(17): 3881-3882.
[12] 祁旦巳,张旭彤,高宝辉,等. 幽门螺杆菌感染与慢性胃炎患者胃 黏膜病理变化的相关性分析[J]. 中华医院感染学杂志,2016,26 (16):3640-642.

备注/Memo

备注/Memo:
基金项目：河南省教育厅科学研究重点项目（15A360016） 作者简介：王军凯，大学本科，主治医师，主要从事消化 内科疾病的病理研究 通信作者：王军凯，Email: doctorw16@126.com
更新日期/Last Update: 2018-09-30