|本期目录/Table of Contents|

[1]李亚红,曾青,张俊梅,等.肥胖与代谢综合征的研究进展[J].慢性病学杂志,2018,(8):1038-1042.
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肥胖与代谢综合征的研究进展(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2018年8期
页码:
1038-1042
栏目:
综 述
出版日期:
2018-08-31

文章信息/Info

Title:
-
作者:
李亚红1;  曾青2;  张俊梅1;  黄祥泓2;  王玉1
1. 兰州大学公共卫生学院，兰州730000； 2. 兰州大学脂20 体重控制科学研究中心，兰州730000
Author(s):
-
关键词:
代谢综合征; 肥胖; 减脂; 精准营养
Keywords:
-
分类号:
R589.2
DOI:
-
摘要:
代谢综合征的发生会增加患心血管疾病及过早死亡的风险，而胰岛素抵抗是代谢综合征的核心。随着研究 者对代谢综合征研究的深入，发现肥胖与代谢综合征的发生紧密联系，而脂肪细胞分泌的脂肪细胞因子是其联系 的桥梁。脂肪细胞因子不仅导致体质量失衡，还会导致机体产生胰岛素抵抗进而引发一系列疾病，包括脂质、血 压、凝血、纤溶和炎症的改变，同时还会导致内皮功能障碍和动脉粥样硬化。通过预防肥胖防治代谢综合征发 展，研究代谢综合征的预防和治疗方案。
Abstract:
-

参考文献/References:


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[5] Van Gaal LF, Mertens IL, De Block C E. Mechanisms linking obesity with cardiovascular disease [J]. Nature, 2006,444(7121):875-880.
[6] Zhang X, Lerman LO. The metabolic syndrome and chronic kidney disease [J]. Transl Res, 2017,183(5):14-25.
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[8] Matsuzawa Y. The metabolic syndrome and adipocytokines [J]. Febs Letters, 2006,580(12):2917-2921.
[9] Beltrán- Sánchez H, Harhay MO, Harhay MM, et al. Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999-2010 [J]. J Am Coll Cardiol, 2013, 62(8):697-703.
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[14] Razani B, Chakravarthy MV, Semenkovich CF. Insulin Resistance and Atherosclerosis [J]. Endocrinol Metab Clin North Am, 2008,37(3):603-621.
[15] Qi Y, Xu Z, Zhu Q, et al. Myocardial loss of IＲS1 and I ＲS2 causes heart failure and is controlled by p38alpha MAPK during insulin resistance [J]. Diabetes, 2013,62(11): 3887-3900.
[16] Adiels M, Borén J, Caslake MJ, et al. Overproduction of VLDL1 Driven by Hyperglycemia Is a Dominant Feature of Diabetic Dyslipidemia [J]. Arterioscler Thromb Vasc Biol, 2005,25(8):1697-1703.
[17] Boucher J, Kahn CR. Differential Roles of Insulin and IGF- 1 Receptor in Brown and White Adipose Tissue and Development of Lipoatrophic Diabetes [J]. Diabetes, 2013, 62:37.
[18] Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance [J]. J Clin Invest, 2006,582(1):97-105.
[19] Guo S, Copps KD, Dong X, et al. The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis [J]. Mol Cell Biol, 2009,29(18): 5070- 5083.
[20] Fu Y, Luo N, Klein RL, et al. Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation [J]. J Lipid Res, 2005,46(7):1369-1379.
[21] Achari AE, Jain SK. Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction [J]. Int J Mol Sci, 2017,18:1321.
[22] Mangge H, Almer G, Truschnig- Wilders M, et al. Inflammation, adiponectin, obesity and cardiovascular risk [J]. Curr Med Chem, 2010,17(36):4511-4520.
[23] Elian V. Weight loss in young obese subjects improves lipids and adipokinges levels and reduces arterial stiffness [J]. Acta Endocrinol, 2013,9(1):79-86.
[24] Oswal A, Yeo G. Leptin and the control of body weight: a review of its diverse central targets, signaling mechanisms, and role in the pathogenesis of obesity [J]. Obesity, 2010,18(2):221-229.
[25] Houde AA, Légaré C, Biron S, et al. Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDLcholesterol levels in severely obese men and women [J]. BMC Med Genet, 2015,16(1):29.
[1] World Health Organization. Obesity and Overweight. Available online [EB/OL] . [2016-11-12]. http://www.who.int/ mediacentre/factsheets/fs311/en.
[2] World Health Organization Regional Office for Europe. Available online [EB/OL] . [2016- 11- 12]. http://www. euro.who.int/data/assets/pdf_file/0003/294474/European- Food-Nutrition-Action-Plan-20152020-en.
[3] World Health Organization. Obesity and Diabetes: The Slow- Motion Disaster Keynote Address at the 47th Meeting of the National Academy of Medicine. Available online. [EB/OL]. [2016-11-12]. http://www.who.int/dg/speeches/ 2016/obesity-diabetes-disaster/en.
[4] Wen J, Yang J, Shi Y, et al. Comparisons of Different Metabolic Syndrome Definitions and Associations with Coronary Heart Disease, Stroke, and Peripheral Arterial Disease in a Rural Chinese Population [J]. Plos One, 2015,10 (5):1-15.
[5] Van Gaal LF, Mertens IL, De Block C E. Mechanisms linking obesity with cardiovascular disease [J]. Nature, 2006,444(7121):875-880.
[6] Zhang X, Lerman LO. The metabolic syndrome and chronic kidney disease [J]. Transl Res, 2017,183(5):14-25.
[7] Reaven GM. Banting lecture 1988 : Role of insulin resistance in human disease [J]. Physiological Reviews, 1988,75 (3):473-486.
[8] Matsuzawa Y. The metabolic syndrome and adipocytokines [J]. Febs Letters, 2006,580(12):2917-2921.
[9] Beltrán- Sánchez H, Harhay MO, Harhay MM, et al. Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999-2010 [J]. J Am Coll Cardiol, 2013, 62(8):697-703.
[10] Xiao J, Wu CL, Gao YX, et al. Prevalence of metabolic syndrome and its risk factors among rural adults in Nantong, China [J]. Sci Rep, 2016,6:38089.
[11] Kassi E, Pervanidou P, Kaltsas G, et al. Metabolic syndrome: definitions and controversies [J]. Bmc Med, 2011,9 (1):48-61.
[12] 中华医学会糖尿病学分会代谢综合征研究协作组.中华医学会糖 尿病学分会关于代谢综合征的建议[J].中国糖尿病杂志,2004,12 (3):156-161.
[13] Robertson MD, Wright JW, Loizon E, et al. Insulin-sensitizing effects on muscle and adipose tissue after dietary fiber intake in men and women with metabolic syndrome [J]. J Clin Endocrinol Metab, 2012,97(9):3326-3332.
[14] Razani B, Chakravarthy MV, Semenkovich CF. Insulin Resistance and Atherosclerosis [J]. Endocrinol Metab Clin North Am, 2008,37(3):603-621.
[15] Qi Y, Xu Z, Zhu Q, et al. Myocardial loss of IＲS1 and I ＲS2 causes heart failure and is controlled by p38alpha MAPK during insulin resistance [J]. Diabetes, 2013,62(11): 3887-3900.
[16] Adiels M, Borén J, Caslake MJ, et al. Overproduction of VLDL1 Driven by Hyperglycemia Is a Dominant Feature of Diabetic Dyslipidemia [J]. Arterioscler Thromb Vasc Biol, 2005,25(8):1697-1703.
[17] Boucher J, Kahn CR. Differential Roles of Insulin and IGF- 1 Receptor in Brown and White Adipose Tissue and Development of Lipoatrophic Diabetes [J]. Diabetes, 2013, 62:37.
[18] Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance [J]. J Clin Invest, 2006,582(1):97-105.
[19] Guo S, Copps KD, Dong X, et al. The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis [J]. Mol Cell Biol, 2009,29(18): 5070- 5083.
[20] Fu Y, Luo N, Klein RL, et al. Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation [J]. J Lipid Res, 2005,46(7):1369-1379.
[21] Achari AE, Jain SK. Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction [J]. Int J Mol Sci, 2017,18:1321.
[22] Mangge H, Almer G, Truschnig- Wilders M, et al. Inflammation, adiponectin, obesity and cardiovascular risk [J]. Curr Med Chem, 2010,17(36):4511-4520.
[23] Elian V. Weight loss in young obese subjects improves lipids and adipokinges levels and reduces arterial stiffness [J]. Acta Endocrinol, 2013,9(1):79-86.
[24] Oswal A, Yeo G. Leptin and the control of body weight: a review of its diverse central targets, signaling mechanisms, and role in the pathogenesis of obesity [J]. Obesity, 2010,18(2):221-229.
[25] Houde AA, Légaré C, Biron S, et al. Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDLcholesterol levels in severely obese men and women [J]. BMC Med Genet, 2015,16(1):29.

备注/Memo

备注/Memo:
作者简介：李亚红，硕士在读，研究方向：公共营养和人 群健康。 通信作者：王玉，E-mail:wangyu@lzu.edu.cn;黄祥泓，Email: felixhuang@zhi20.com
更新日期/Last Update: 2018-08-30