|本期目录/Table of Contents|

[1]鲁琳,李永秋,于大勇,等.肥胖阿尔茨海默病患者血清脂联素和瘦素的水平及意义[J].慢性病学杂志,2018,(8):1002-1004.
　LU Lin*,LI Yong-qiu,YU Da-yong,et al.Levels of the adiponectin and leptin in serum of obese patients with Alzheimer’s Disease[J].,2018,(8):1002-1004.
点击复制

肥胖阿尔茨海默病患者血清脂联素和瘦素的水平及意义(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2018年8期
页码:
1002-1004
栏目:
论　著
出版日期:
2018-08-31

文章信息/Info

Title:
Levels of the adiponectin and leptin in serum of obese patients with Alzheimer’s Disease
作者:
鲁琳1;  李永秋1;  于大勇2;  王颖3;  付子娟1;  吴冰4;  李相华1;  张冬森1
1. 唐山市工人医院神内一科，河北唐山063000； 2. 唐山市丰润区人民医院重症医学科，河北唐山064000； 3. 唐山市工人医院急诊综合病区监护室，河北唐山063000； 4. 唐山市工人医院检验科，河北唐山063000
Author(s):
LU Lin*;  LI Yong-qiu;  YU Da-yong;  WANG Ying;  FU Zi-juan;  WU Bing;  LI Xiang-hua;  ZHANG Dong-sen
*The First Department of Neurology, Tangshan Gongren Hospital, Tangshan, Hebei 063000, China Corresponding author: LI Yong-qiu, E-mail: yongqiuli@126.com
关键词:
阿尔茨海默病; 肥胖; 脂联素; 瘦素
Keywords:
Alzheimer’s disease;  Obesity;  Adiponectin;  Leptin
分类号:
R589.2
DOI:
-
摘要:
目的探讨肥胖阿尔茨海默病（AD） 患者血清脂联素和血清瘦素的临床特点，为临床诊断提供参考。 方法选取肥胖的30 例AD 患者作为肥胖组，非肥胖的35 例AD 患者作为对照组，同期健康人30 例作为健康 组，测定三组人群血清脂联素和瘦素水平。结果肥胖组血清脂联素[ （20.14±1.76） ng/ml]明显低于对照组 [ （28.16±2.34） ng/ml]和健康组[ （47.58±5.72） ng/ml]，差异有统计学意义（P<0.05）；对照组血清脂联素显著 低于健康组（P<0.05）；肥胖组血清瘦素水平[ （3.32±0.71） ng/ml]明显高于对照组[ （2.12±0.98） ng/ml，P< 0.05） ]，但低于健康组[ （6.83±0.85） ng/ml，P<0.05]；对照组血清瘦素水平显著低于健康组（P<0.05）。结论 AD 与机体内脂联素和瘦素的水平有关，且肥胖对脂联素及瘦素有一定影响。
Abstract:
Objective To explore the clinical character of adiponectin and leptin in serum of obese patients with Alzheimer’s disease （AD） . Methods Thirty obese patients with AD were selected as obese group; 35 non-obese patients with AD were selected as control group; 30 healthy people were selected as healthy group. The levels of adiponectin and leptin in serum of the three groups were measured and compared. Results The serum level of adiponectin in obese group [ （20.14±1.76） ng/ml] was significantly lower than that in control group [ （28.16±2.34） ng/ml] and healthy group [ （47.58± 5.72） ng/ml] （P<0.05） , and the level of adiponectin in control group was significantly lower than that in healthy group （P<0.05） . The serum level of leptin in obese group [ （3.32±0.71） ng/ml] was significantly higher than that in control group [ （2.12±0.98） ng/ml] （P<0.05） , and they were all lower than that in healthy group [ （6.83 ± 0.85） ng/ml] （P<0.05） . Conclusion AD is associated with adiponectin and leptin levels, and obesity has some effects on adiponectin and leptin.

参考文献/References:


[1] 刘悦,晏勇. 脂联素与老年性痴呆的研究进展[J]. 重庆医学,2013 (21):2543-2545.
[2] Fang X, Sweeney G. Mechanisms regulating energy me tabolism by adiponectin in obesity and diabetes [J]. Biochem Soc Trans, 2006,34(Pt5):798-801.
[3] 毛红仙,汪大望. 瘦素、抵抗素是联系肥胖与糖代谢异常和脂代 谢异常的纽带和桥梁吗[J]. 浙江医学,2003,25(5):319-321.
[4] Behnwski J. Apelinarut visfatin: unique “beneficial” adipokines upregulated in obesity [J]. Med Sci Monit, 2006,12 (6):RA112-119.
[5] Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose- specific protein, adiponectin, in obesity. 1999 [J]. Biochem Biophys Res Commun, 2012,425(3): 560-564.
[6] HottaK, Funahashi T, Arita Y, et al. Plasma concentrations of a novel adiposes specific protein, adiponectin in type 2 diabetic patients [J]. Arterioscler Thromb Vasc Biol, 2000,20(6):1595-1599.
[7] Psilopanagioti A, Papadaki H, Kranioti EF, et al. Expression of adiponectin and adiponectin receptors in human pituitary gland and brain [J]. Neuroendocrinology, 2009,89(1): 38-47.
[8] Kamogawa K, Kohara K, Tabara Y, et al. Abdominal fat, adipose- derived hormones and mild cognitive impairment: the J- SHIPP study [J]. Dement Geriatr Cogn Disord, 2010,30(5):432-439.
[9] Tvarijonaviciute A, Carrillo- Sanchez JD, Ceron JJ. Effect of estradiol and progesterone on metabolic biomarkers in healthy bitches [J]. Reprod Domest Anim, 2013,48(3):520- 524.
[10] 赵菊兰,夏天,李荣,等. 单纯性肥胖患者血清脂联素、血清瘦素 与肾损伤的相关性分析[J]. 天津医科大学学报,2016,22(1):34- 40.
[11] 王春艳,杜瑞平,张兴夫,等.瘦素及其生理功能概述[J].动物营养 学报,2012,24(3):423-427.
[12] Weng Z, Signore AP, Gao Y, et al. Leptin protects against 6- hydroxydopamine- induced dopaminergic cell death via mitogen- activated protein kinase signaling [J]. J Biol Chem, 2007,282 (47):34479-34491.

备注/Memo

备注/Memo:
基金项目： 河北省卫生和计划生育委员会医学科学研究重点 课题计划（20171376）；河北省卫生计生委2017 年度医学科学研究课题计划项目 作者简介：鲁琳，本科，主治医师，研究方向：神经内科 通信作者：李永秋，E-mail：yongqiuli@126.com
更新日期/Last Update: 2018-08-30