|本期目录/Table of Contents|

[1]李慧,吴云,赵兴胜.1/4 剂量的四联疗法初步治疗高血压的研究现状[J].慢性病学杂志,2017,(10):1114-1117.
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1/4 剂量的四联疗法初步治疗高血压的研究现状(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2017年10期
页码:
1114-1117
栏目:
综述
出版日期:
2017-11-05

文章信息/Info

Title:
-
作者:
李慧1 吴云2 赵兴胜2
1. 内蒙古医科大学,呼和浩特010010;2. 内蒙古自治区人民医院,呼和浩特010010
Author(s):
-
关键词:
高血压低剂量联合疗法药物四分之一剂量治疗
Keywords:
-
分类号:
R544.1
DOI:
-
摘要:
高血压是最常见的慢性非传染性疾病,具有“三高”——高患病率、高致残率、高死亡率,“三低”—— 低知晓率、低控制率、低治愈率的特点。其中,低控制率是阻碍高血压降压达标的关键因素。目前,高血压多采 用联合疗法实现有效降压,本文就高血压低剂量联合疗法的相关研究进行了综述,特别提出了药物四分之一剂量 治疗(Quadpill) 这一新概念,即:分别取A、B、C、D (尤指噻嗪类) 四类降压药标准剂量的四分之一,联合 制成一枚复方药丸,作为高血压的初始治疗方案。鉴于四分之一剂量四联降压疗法可以在保证最优降压效果的同 时降低不良反应的发生率,故未来将成为高血压防治策略的新趋势。
Abstract:
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参考文献/References:

[1] Lim SS, Vos T, Flaxman AD, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990- 2010: a systematic analysis for the Global Burden of Disease Study 2010 [J]. Lancet, 2012,380(9859):2224-2260.
[2] Chow CK, Teo KK, Rangarajan S, et al. PURE (Prospective Urban Rural Epidemiology) Study investigators. Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high, middle, and low-income countries [J]. JAMA, 2013(310):959- 968.
[3] Gradman AH. Rationale for triple- combination therapy for management of high blood pressure [J]. J Clin Hypertens (Greenwich), 2010,12(11):869-878.
[4] Law MR, Wald NJ, Morris JK, et al. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials [J]. BMJ, 2003,326(7404): 1427.
[5] Gradman AH, Basile JN, Carter BL, et al. Combination therapy in hypertension[J]. J Clin Hypertens (Greenwich), 2011,13(3):146-154.
[6] Neaton JD, Grimm RU Jr, Prineas RJ, et al. Treatment of mild hypertension study.Final results [J]. JAMA,1993, 270(6):713-724.
[7] Mahmud A, Feely J. Low- Dose Quadruple Antihypertensive Combination More Efficacious Than Individual Agents- A Preliminary Report [J]. Hypertension, 2007,49(2):272.
[8] Chow G, Thakkar J, Bennett A, et al. Quarter-dose quadruple combination therapy for initial treatment of hypertension: placebo- controlled, crossover, randomised trial and systematic review [J]. Lancet, 2017,389(10073):1035-1042.
[9] Mancia G, Rea F, Cuspidi C, et al. Blood pressure control in hypertension. Pros and cons of available treatment strategies [J]. J Hypertens, 2017,35(2):225-233.
[10] Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ ESC guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC) [J]. J Hypertens, 2013,31(7):1281-1357.
[11] Mancia G, Omboni S, Parati G, et al. Clinical value of ambulatory blood pressure monitoring [J]. Hypertension, 2015,116(6):1034-1045.
[12] The SPRINT Research Group, Wright JT Jr, Williamson JD, et al. A randomized trial of intensive versus standard blood pressure control [J]. N Engl J Med, 2015,373(22): 2103-2116.
[13] Ettehad D, Emdin CA, Kiran A, et al. Blood pressure lowering for prevention of cardiovascular disease and death. A systematic review and meta- analysis [J]. Lancet, 2016, 387(10022):957-961.
[14] Mancia G, Parati G. Office compared with ambulatory blood pressure in assessing response to antihypertensive treatment: a meta analysis [J]. J Hypertens, 2004,22(3): 435-445.
[15] Mancia G, Grassi G. Systolic and diastolic blood pressure control in antihypertensive drug trials [J]. J Hypertens, 2002,20(8):1461-1464.
[16] Bennett A, Chow CK, Chou M, et al. Efficacy and Safety of Quarter- Dose Blood Pressure- Lowering Agents: A Systematic Review and Meta- Analysis of Randomized Controlled Trials [J]. Hypertension, 2017,70(1):85-93.
[17] Wald DS, Morris JK, Wald NJ, et al. Randomized Polypill crossover trial in people aged 50 and over [J]. PLoS One, 2012,7(7):e41297.
[18] Holzgreve H. Combination versus Monotherapy as Initial Treatment in Hypertension [J]. Herz, 2003,28(8):725-732.
[19] Jones DW, Hall JE. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure and Evidence from new Hypertension Trials [J]. Hypertension, 2004,43(1):1-3.
[20] Weber MA, Julius S, Kjeldsen SE, et al. Blood pressure dependent and independent effects of antihypertensive treatment on clinical events in the VALUE trial [J]. Lancet, 2004,363(9426):2049-2051.

备注/Memo

备注/Memo:
资助项目:内蒙古自治区科技创新引导项目 作者简介:李慧,硕士研究生,研究方向:高血压 通讯作者:赵兴胜,E-mail:zhaoxs1121@163.com
更新日期/Last Update: 2017-10-30