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[1]刘芳会,周迎生,赵一楠,等.冠心病合并糖尿病死亡患者代谢性危险因素分析[J].慢性病学杂志,2016,(08):838-841.
　LIU Fang-Hui,ZHOU Ying-sheng,ZHAO Yi-nan,et al.Metabolic risk factors in patients died of coronary artery disease and diabetes mellitus[J].,2016,(08):838-841.
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冠心病合并糖尿病死亡患者代谢性危险因素分析(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2016年08期
页码:
838-841
栏目:
内分泌代谢专栏
出版日期:
2016-09-27

文章信息/Info

Title:
Metabolic risk factors in patients died of coronary artery disease and diabetes mellitus
作者:
刘芳会1; 周迎生1; 赵一楠2; 刘静2
1. 首都医科大学附属北京安贞医院内分泌代谢科，北京100029； 2. 北京市心肺血管疾病研究所，北京100029
Author(s):
LIU Fang-Hui;  ZHOU Ying-sheng;  ZHAO Yi-nan;  LIU Jing
Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China Corresponding author: ZHOU Ying-sheng, E-mail: yszhou@ccmu.edu.cn
关键词:
冠心病; 糖尿病; 死亡; 甘油三酯
Keywords:
Diabetes mellitus;  Coronary arteryt disease;  Death;  Triglyceride
分类号:
R587.1
DOI:
-
摘要:
目的回顾性分析冠心病合并糖尿病死亡患者代谢异常特征。方法采用病例对照法，选取2006 年11 月-2016 年3 月近十年间在北京安贞医院心内科住院的冠心病合并糖尿病死亡患者52 例为病例组， 冠心病无糖尿病死亡患者52 例为对照组。所有入选患者以心血管疾病为首要死因且病案资料完整，组间性 别及年龄均匹配。比较一般资料及代谢性指标如总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、空 腹血糖、糖化血红蛋白、血尿酸等。结果冠心病合并糖尿病死亡患者冠心病病程、吸烟史、住院次数及 血脂异常与对照组相比，差异有统计学意义（P＜0.05）；空腹血糖、糖化血红蛋白与对照组相比，差异有 统计学意义（P＜0.01）； 血脂代谢指标中仅甘油三酯水平与对照组相比， 差异有统计学意义（P=0.01）。 结论血糖及甘油三酯水平升高是冠心病合并糖尿病死亡患者的主要代谢异常特征。
Abstract:
Objective To retrospectively analyze the characters of metabolism in patients died of coronary artery disease (CAD) who complicated diabetes mellitus (DM). Methods A total of 52 cases with CAD and DM (CADDM) as case group and 52 CAD patients without DM (CAD-NDM) as the control group were enrolled in this casecontrol study in Beijing Anzhen Hospital between November 2006 to March 2016. Two groups were matched for sex and age. Clinical and demographic date were collected. Metabolic parameters such as total cholesterol, triglycerides, low density lipoprotein, high density lipoprotein, fasting blood glucose, glycosyl ated hemoglobin, serum uric acid and coronary artery lesions betweem two groups were compared. Results The disease course of CAD, smoking, dyslipidemia and number of hospitalizations were significant different (P＜0.05) between CAD- DM group and CAD- NDM group. The differences of fasting blood glucose and glycosylated hemoglobin between the two groups were statistically significant (P<0.001). In blood lipid, the significant difference was only been observed in triglyceride (P=0.011). Conclusions The increased blood glucose and triglycerides are the main characteristics of metabolic disorders in patients died of coronary artery disease and diabetes mellitus.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金资助项目（81041024）；教育部留学回国基金资助项目（2012-940）；北京市学科带头人基金资助 项目（2013-2-006）；北京市科委科研基金资助项目（Z131100004013044）；北京市保健课题［北京市保健办发(2015)35 号］ 作者简介：刘芳会，在读研究生，研究方向：2 型糖尿病、肥胖发病机制及心血管并发症防治 通信作者：周迎生，E-mail: yszhou@ccmu.edu.cn
更新日期/Last Update: 2016-09-27