|本期目录/Table of Contents|

[1]朱玮玮,华琦.GNB3 基因C825T 位多态性与高血压患者发生心脑血管事件相关性研究进展[J].慢性病学杂志,2015,(6):658-660.
点击复制

GNB3 基因C825T 位多态性与高血压患者发生心脑血管事件相关性研究进展(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2015年6期
页码:
658-660
栏目:
综 述
出版日期:
2015-12-27

文章信息/Info

Title:
-
作者:
朱玮玮;  华琦
首都医科大学宣武医院心脏科，北京100053
Author(s):
-
关键词:
G 蛋白; 基因多态性; 高血压; 心脑血管事件
Keywords:
-
分类号:
R394.5；R541.3
DOI:
-
摘要:
心脑血管事件是东方国家死亡的首要原因，已经成为世界关注的健康问题。另外，高血压是心血管疾 病中发生率最高的疾病，在其发生中起重要作用。研究表明GNB3 基因C825T 多态性与高血压、肥胖、糖 尿病有关。而这些都是心脑血管疾病的危险因素，它们可能有共同的遗传特点。因此，研究此基因多态性 在心血管事件和高血压发生、发展中的作用意义重大。
Abstract:
-

参考文献/References:

［1] Fernández- Real JM, Pe?arroja G, Richart C, et al. G protein beta3 gene variant, vascular function, and insulin sensitivity in type 2 diabetes ［J]. Hypertension, 2003,41(1):124-129. [/br]［2］ Brand E, Wang JG, Herrmann SM, et al. An epidemiological study of blood pressure and metabolic phenotypes in relation to the Gβ3C825T polymorphism ［J]. Hypertension, 2003,21 (4):729-737. [/br]［3］ Siffert W, Rosskopf D, Siffert G, et al. Association of a hu? man G protein β3 subunit varaiant with hypertension ［J]. Nat Genet, 1998,18(1):45-48. [/br]［4］ Hengstenberg C, Schunkert H, Mayer B, et al. Association between a polymorphism in the G protein beta3 subunit gene (GNB3) with arterial hypertension but not with myocardial in? farction ［J]. Cardiovasc Res, 2001,49(4):820-827. [/br]［5］ Siffert W, Forster P, Jockel KH, et al. Worldwide ethnic dis? tribution of the G protein beta3 subunit 825T allele and its asso? ciation with obesity in Caucasian, Chinese, and Black African individuals ［J]. Am Soc Nephrol, 1999,10(9):1921-1930. [/br]［6］ Larson N, Hutchinson R, Boerwinkle E. Lack of association of 3 functional variants with hypertension in African Americans ［J]. Hypertension,2000,35(6):1297-1300. [/br]［7］ Ishikawa K, Imai Y, Katsuya T, et al. Human G- protein be? ta3 subunit variant is associated with serum potassium and total cholesterol levels but not with blood pressure ［J]. Am J Hy? pertens, 2000,13(2):140-145. [/br]［8］ Tsai CH, Yeh HI, Chou Y, et al. G protein beta3 subunit and essential hypertension in Taiwan: a case- control study ［J]. Int J Cardiol,2000,73(2):191-195. [/br]［9］ Hegele RA, Harris SB, Hanley AJG, et al. G protein b 3 sub? unit gene variant and blood pressure variation in Canadian Oji- Cree ［J]. Hypertension,1998,32(4):688-692. [/br]［10］ Huang X, Ju Z, Song Y, et al. Lack of association between the G protein beta3 subunit gene and essential hypertension in Chi? nese: a case- control and a family- based study ［J]. J Mol Med (Berl), 2003,81(11):729-735. [/br]［11］ Zethelius B, Berglund L, Sundstrom J, et al. Use of multiple biomarkers to improve the prediction of death from cardiovas? cular causes ［J]. N Engl J Med, 2008,358(20):2107-2116. [/br]［12］ Melander O, Newton- Cheh C, Almgren P, et al. Novel and conventional biomarkers for prediction of incident cardiovascu? lar events in the community ［J]. Am Med Assoc, 2009,302 (1):49-57. [/br]［13］ Daimon M, Sato H, Kaino W, et al. Association of the G-pro? tein β3 subunit gene polymorphism with the incidence of cardio? vascular disease independent of hypertension: the Funagata study ［J]. Hum Hypertension, 2013,27(10):612-616. [/br]［14］ Frey UH, Moebus S, M?hlenkamp S, et al. GNB3 gene 825 TT variant predicts hard coronary events in the populationbased Heinz Nixdorf Recall study ［J]. Atherosclerosis,2014, 237(2):437-442. [/br]［15］ von Beckerath N, Schusterschitz Y, Koch W, et al. G protein beta 3 subunit 825T allele carriage and risk of coronary artery disease ［J]. Atherosclerosis, 2003,167(1):135-139. [/br]［16］ Bagos PG, Elefsinioti AL, Nikolopoulos GK, et al. The GNB3 C825T polymorphism and essential hypertension: a me? ta- analysis of 34 studies including 14,094 cases and 17,760 controls ［J]. Hypertens, 2007,25(3):487-500. [/br]［17］ Morrison AC, Doris PA, Folsom AR, et al. G- protein beta3 subunit and alpha- adducin polymorphisms and risk of subclini? cal and clinical stroke ［J]. Stroke, 2001,32(4):822-829. [/br]［18］ Naber CK, Husing J, Wolfhard U, et al. Interaction of the ACE D allele and the GNB3 825T allele in myocardial infarc? tion ［J]. Hypertension, 2000,36(6):986- 989. [/br]［19］ Yamada Y, Izawa H, Ichihara S, et al. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes［J]. N Engl J Med, 2002,347(24):1916-1923. [/br]［20］ Ansari- Lari MA, Muzny DM, Lu J, et al. A gene- rich clus? ter between the CD4 and triosephosphate isomerase genes at human chromosome 12p13 ［J]. Genome Res, 1996,6(4):314- 326. [/br]［21］ Naber C, Hermann BL, Vietzke D, et al. Enhanced epineph? rine induced platelet aggregation in individuals carrying the G protein beta3 subunit 825T allele ［J]. FEBS Lett, 2000,484 (3):199-201. [/br]［22］ McBride CA, Hale SA, Subramanian M, et al. The relation? ship of a family history forhypertension, myocardial infarction, or stroke with cardiovascular physiology in young women ［J]. Reprod Sci, 2014,21(4):509-516. [/br]［23］ Dong Y, Zhu H, Wang X, et al. Obesity reveals an association between blood pressure and the G- protein beta3- subunit gene: a study of female dizygotic twins ［J]. Pharmacogenet? ics, 2004,14(7):419-427. [/br]［24］ Casiglia E, Tikhonoff V, Boschetti G, et al. The C825T GNB3 polymorphism, independent of blood pressure, predicts cerebrovascular risk at a population level ［J]. Am J Hyper? tens, 2012,25(4):451-457. [/br]［25］ Morrison AC, Doris PA, Folsom AR, et al. Atherosclerosis Risk in Communities Study. G- protein beta3 subunit and al? pha- adducin polymorphisms and risk of subclinical and clinical stroke ［J]. Stroke, 2001,32(4):822-829. [/br]［26］ Zhang L, Zhang H, Sun K, et al. The 825C/T polymorphism of G- protein beta3 subunit gene and risk of ischaemic stroke ［J]. J Hum Hypertens, 2005,19(9):709-714. [/br]［27］ Kostulas K, Brophy VH, Moraitis K, et al. Genetic profile of ischemic cerebrovascular disease and carotid stenosis ［J]. Ac? ta Neurol Scand, 2008,118(3):146-152.

备注/Memo

备注/Memo:
基金项目：国家863 计划项目（2012AA02A516） 作者简介：朱玮玮，在读博士，住院医师，主要从事高血 压疾病研究。 通信作者：华琦，E-mail: huaqi5371@medmail.com.cn
更新日期/Last Update: 2015-12-27