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[1]叶俏.特发性肺纤维化与胃食管反流的研究进展[J].慢性病学杂志,2015,(01):39-43.
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特发性肺纤维化与胃食管反流的研究进展(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2015年01期
页码:
39-43
栏目:
综述
出版日期:
2015-01-29

文章信息/Info

Title:
-
作者:
叶俏
首都医科大学附属北京朝阳医院，职业病与中毒医学科，北京100020
Author(s):
-
关键词:
特发性肺纤维化; 胃食管反流; 肺损伤
Keywords:
-
分类号:
R563.9
DOI:
-
摘要:
特发性肺纤维化（IPF） 是一类慢性纤维化性肺疾病，隐匿起病，迅速进展，导致患者发生呼吸衰竭 和死亡。IPF 病因不清，其发病可能与易感基因、老龄、烟草暴露、环境因素、病毒、免疫失衡，以及慢 性胃肠道酸或非酸物质反流和吸入等因素有关。目前的假说认为，具有易感倾向的个体，尤其是老龄人群 反复慢性微吸入引起肺泡上皮细胞损伤和修复异常，导致肺成纤维细胞增殖和活化，胶原沉积和肺纤维化 形成。IPF 合并高发的胃食管反流为假说提供了依据。部分IPF 急性加重患者的支气管肺泡灌洗液中可以 检测到增高的胃蛋白酶，为胃液成分进入下呼吸道提供了直接的证据，提示慢性微吸入可能在IPF 急性加 重中起作用。药物或外科治疗胃食管反流可以使IPF 患者肺功能维持稳定，抗胃食管反流为IPF 的治疗提 供了新的靶点。目前，亟待进行前瞻性临床研究，观察干预胃食管反流对IPF 疾病病程的影响，进一步阐 明胃食管反流与IPF 病情进展的关系。
Abstract:
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参考文献/References:

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金面上项目（81370159）；北 京自然科学基金面上项目（7142058） 作者简介：叶俏，博士，主任医师，主要从事呼吸系统 病的研究工作 通信作者：叶俏，E-mail: birmyeqiao@sina.com
更新日期/Last Update: 2015-01-15