|本期目录/Table of Contents|

[1]万海伟,杨士伟.双联抗血小板治疗的有效性与安全性评价研究进展[J].慢性病学杂志,2015,(02):195-197.
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双联抗血小板治疗的有效性与安全性评价研究进展(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2015年02期
页码:
195-197
栏目:
综述
出版日期:
2015-04-30

文章信息/Info

Title:
-
作者:
万海伟1;  杨士伟2
1.山东省兖州市中医院，山东济宁272100；2.首都医科大学附属北京安贞医院，北京100029
Author(s):
-
关键词:
经皮冠状动脉介入治疗; 血小板; 阿司匹林; 氯比格雷
Keywords:
-
分类号:
R541.4
DOI:
-
摘要:
经皮冠状动脉介入治疗（PCI） 作为治疗冠心病的有效手段，取得了令人满意效果，且已成为与药物 和外科手术并驾齐驱治疗冠心病的重要手段。阿司匹林和氯比格雷双联抗血小板的治疗预防支架内再狭窄 和血栓事件的发生已成为PCI 围手术期常规的治疗方案，但仍有相当一部分患者发生缺血或出血事件。
Abstract:
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参考文献/References:

[1] Mehta SR, Yusuf S, Peter RJ, et al. Effects of pretreatment with clopidogrel ang aspirin followed by long - term therapy in patients undergoing percutaneous coronary intervention:the PCI-CURE study [J]. Lancet, 2001,358(9281):527-533.
[2] Steinhubl SR, Berger PB, Mann JT, et al. Clopidogrel for the reduction of events dueing observation,Early and sustained du? al oral antiplatelet therapy following percutaneous coronary: a randomized controlled trial [J]. JAMA, 2002,288(19):2411.
[3] 陈军浩,叶树俊,胡锡池.全血电阻抗法和比浊法检测血小板聚 集率方法学比较[D].上海:中国科学院上海冶金研究所,2000.
[4] Hobson AR, Petley GW, Dawkins KD, et al. A novel fifteen minute test of in diviual time- dependent clotting responses to asprin and clopidogrel using modified throm be lastography [J]. Platelets, 2007,18(7):497-505.
[5] 李开亮,司全金,张帷.双联抗血小板治疗急性冠脉综合征临床 疗效观察[J].现代生物医学进展,2011,7(3):1305-1307.
[6] Eikeboom IW, Mentha SR, Anand SS, et al. Adverse impact of bleeding on prognosis in patients with acute coronary syn? dromes [J]. Circulation, 2006,114(8):774-782.
[7] 周爱琴,王小萍,廖伟,等.急性心肌梗死出血患者院外抗血小板 药物使用的随访研究[J].临床心血管病杂志,2010,1(26):36- 38.
[8] Gurbel PA, Bliden KP, SamaraW, et al. Clopidogrel effect on platelet reactivity in patients with rombosis :resuts of the CREST Study [J]. J Am Coll Cardiol, 2005,46:1827-1832.
[9] Gurbel PAJ, Blliden KP, Tantry US, et al. Platelet function measured by VerifyNowtrade mark identifies generalized high platelete reactivity in asprin treated patients [J]. Platelets, 2007,18(16):3156-3164.
[10] Blidem KP, Dichiara J, Tantryu S, et al.Increased risk in pa? tients with high platelet aggregation receiving chronic clopido? grel therapy undergoing percutaneous coronary intervention: is the current antiplatelet therapy adequate [J]. Am Coll cardiol, 2007,49(6):657-666.
[11] Michelson AD. Platelet function testing in cardiovascular dis? eases [J]. Circulation, 2004,110(19):e489-e493.
[12] Kastrati A, Beckerath N, Joost A, et al. Loading with 600 mg clopidogrel in patients with coronary disease with coronary ar? tery disease with and without chronic clopidogrel therapy [J]. Circulation, 2004,110(14):1916-1919.
[13] 严晓伟.抗血小板药物的研发进展[J].中国循环杂志,2011,2 (26):4-5.
[14] Wivioa SD, Antman EM, Gibson CM, et al. Evaluation of prasugrel compared with clop idogrel in patients with acute cor? onary syndromes: design and rationale for the TR ial to assess Improvement ifl Therapeutic O utcomes by optimizing platelet Inhibition with prasugrel Thrombolysis In Myocardial Infarc? tion 38 (TRIT- 11MI38) [J]. Am Heart J, 2006,152(4):627- 635.
[15] Wiviott SD, Trenk D, Frelnger AL, et al. Prasugrel compared with high loading and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention:the prasugrel in comparison to clopidogrel for inhibition of platelet activation and aggregation- throm bolysis in myocardial infarction 44 trial [J]. Circulation, 2007,116(25):2923-2932.
[16] Greenbaum AB, Grines CL, Bittl JA, et al. Initial experience with an intravenous P2Y12platelet receptor antagonist in pa? tients under going percutaneous coronary intervention:results from a 2- part phase II, multicenter, randomized, placebo and active contrail [J]. Am Heart J, 2006,151(3):689-698.

备注/Memo

备注/Memo:
基金项目：国家自然科学基金资助项目（81100143）；北 京市教委重点项目（KZ201110025031）； 首 都临床特色应用研究重点项目（Z0005190042811）； 北京市科技新星项目（Z121107002512053） 作者简介：万海伟，大学本科，主治医师，主要从事冠心 病介入治疗等工作 通信作者：万海伟，E-mail: sci2011@163.com
更新日期/Last Update: 2015-04-15