|本期目录/Table of Contents|

[1]刘华,孙善会,肖东杰,等.间充质干细胞治疗哮喘的作用研究进展[J].慢性病学杂志,2013,(09):682-684.
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间充质干细胞治疗哮喘的作用研究进展(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2013年09期
页码:
682-684
栏目:
综述
出版日期:
2013-09-30

文章信息/Info

Title:
-
作者:
刘华1; 2; 孙善会1; 肖东杰1; 2; 杨坦1; 汪运山1; 2
1.山东大学附属济南市中心医院中心实验室,山东 济南 250013; 2.山东省移植与组织工程研究中心,山东 济南 250013
Author(s):
-
关键词:
间充质干细胞;  哮喘;  治疗
Keywords:
-
分类号:
R562.2+5
DOI:
-
摘要:
哮喘作为一种慢性炎症疾患,其发病率在世界范围内仍呈上升趋势。目前研究表明哮喘是多个免疫细胞参与的气道炎症与高反应疾病,其中CD4+T淋巴细胞在调控气道炎症中发挥主要作用。目前以糖皮质激素为首的抗炎药物联合长效β2受体激动剂为主的症状缓解药物作为一线治疗方案,并不能达到哮喘的理想控制效果及逆转哮喘病理改变,因此有必要寻求哮喘防治新方法。间充质干细胞是一类具有高度可塑性的细胞群体,除具有多向分化潜能外,还具有免疫调节作用。目前研究表明间充质干细胞可定植到肺组织并分化为肺上皮细胞,通过免疫调节作用,改善Th1/Th2失衡,上调Treg细胞数量,调控Th17比例等机制缓解哮喘病情。目前间充质干细胞治疗哮喘的大多数实验尚停留在动物实验水平,临床应用较少,间充质干细胞移植在临床中的应用尚面临巨大的挑战。
Abstract:
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参考文献/References:

[1] 钟南山,徐军,施焕军,等.支气管哮端基础与临床[M].北京:人民卫生出版社,2006: 1-14.
[2] Poon AH,Eidelman DH,Martin JG,et al.Pathogenesis of severe asthma[J].Clin Exp Allergy,2012,42(5):625-637.
[3] Anderson GP.Endotyping asthma:new insights into key pathogenic mechanisms in a complex,heterogeneous disease[J].Lancet,2008,372(9643):1107-1119.
[4] Robinson DS,Hamid Q,Ying S,et al.Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma[J].N Engl J Med,1992,30,326(5):298-304.
[5] 周辰,陈军浩,殷凯生.辅助性T细胞17和调节性T细胞在哮喘小鼠中的失衡表达及其意义[J].中国呼吸与危重监护杂志,2010,9(1):28-31.
[6] 施宇衡,时国朝,万欢英.支气管哮喘患者外周血Th17、CD4+CD25+Treg细胞表达特征[J].中国免疫学杂志,2010,26,740-743.
[7] Mishra A,Yao X,Levine SJ.From bedside to bench to clinic trials: identifying new treatments for severe asthma[J].Dis Model Mech,2013,6(4):877-888.
[8] 林慧婷,蔡飒,潘宇,等.骨髓间充质干细胞移植在哮喘小鼠肺组织中的作用[J].感染、炎症、修复,2012,13(3):134-137.
[9] 黄芸,欧阳海峰,吴朔,等.外源性间充质干细胞减轻支气管哮喘小鼠气道炎症的研究[J].国际呼吸杂志,2010,30(11):102-106.
[10] Sueblinvong V,Loi R,Eisenhauer PL,et al.Derivation of lung epithelium from human cord blood-derived mesenchymal stem cells[J].Am J Respir Crit Care Med,2008,177(7):701.
[11] Mac Sweeney R,McAuley DF.Mesenchymal stem cell therapy in acute lung injury: is it time for a clinical trial[J].Thorax,2012,67(6):475-476.
[12] Abreu SC,Antunes MA,de Castro JC,et al.Bone marrow-derived mononuclear cells vs.mesenchymal stromal cells in experimental allergic asthma[J].Respir Physiol Neurobiol,2013,187(2):190-198.
[13] Krampera M,Glennie S,Dyson J,et al.Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide[J].Blood,2003,101(9):3722-3729.
[14] Ge X,Bai C,Yang J,et al.Effect of mesenchymal stem cells on inhibiting airway remodeling and airway inflammation in chronic asthma[J].J Cell Biochem,2013,114(7):1595-1605.
[15] Sun YQ,Deng MX,He J,et al.Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice[J].Stem Cells,2012,30(12):2692-2699.
[16] Di Ianni M,Del Papa B,De Ioanni M,et al.Mesenchymal cells recruit and regulate T regulatory cells[J].Exp Hematol,2008,36(3):309-318.
[17] Ge X,Bai C,Yang J,et al.Intratracheal transplantation of bone marrow-derived mesenchymal stem cells reduced airway inflammation and up-regulated CD4(+)CD25(+)regulatory T cells in asthmatic mouse[J].Cell Biol Int,2013,37(7):675-686.
[18] 李建国,颛孙永勋,冉丕鑫,等.骨髓间充质干细胞对哮喘小鼠CD4+CD25+调节性T 细胞及气道炎症的影响[J].中国组织工程研究及临床康复,2008,12(47):9302-9305.
[19] Guo Z,Zheng C,Chen Z,et al.Fetal BM-derived mesenchymal stem cells promote the expansion of human Th17 cells,but inhibit the production of Th1 cells[J].Eur J Immunol,2009,39(10):2840-2849.
[20] Rafei M,Campeau PM,Aguilar-Mahecha A,et al.Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner[J].J Immunol,2009,182(10):5994-6002.
[21] 刘华,陈亚娜,郑燕,等.人脐带间充质干细胞对宫颈癌Hela细胞增殖的影响[J].山东大学学报(医学版),2013,51(6): 29-33.
[22] Ye H,Cheng J,Tang Y,et al.Human bone marrow-derived mesenchymal stem cells produced TGF beta contributes to progression and metastasis of prostate cancer[J].Cancer Invest,2012,30(7):513-518.
[23] De Boeck A,Pauwels P,Hensen K,et al.Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signalling[J].Gut,2013,62(4):550-560.

备注/Memo

备注/Memo:
本文为“泉城之秋——陆台莱姆病研讨会暨免疫病学中国泰山论坛”征文 基金项目:国家青年科学基金项目(81200950); 山东省医药卫生科技发展计划项目(2011QW002); 济南市青年科技明星计划(20100316) 作者简介:刘华,博士,检验技师,主要从事干细胞基础研究及临床应用研究 通讯作者:汪运山,E-mail:sdjnwys@163.com
更新日期/Last Update: 2013-09-30