|本期目录/Table of Contents|

[1]孙丽娜.ＶＥＧＦ、ＭＣＰ１、ＣＴＧＦ与糖尿病肾病关系的研究进展[J].慢性病学杂志,2013,(02):127-129.
点击复制

ＶＥＧＦ、ＭＣＰ１、ＣＴＧＦ与糖尿病肾病关系的研究进展(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2013年02期
页码:
127-129
栏目:
综述
出版日期:
2013-02-28

文章信息/Info

Title:
-
作者:
孙丽娜
盘锦市中心医院输血科,辽宁 盘锦 124010
Author(s):
-
关键词:
血管内皮生长因子;  单核细胞趋化蛋白-1;  结缔组织生长因子;  糖尿病肾病
Keywords:
-
分类号:
R587.2
DOI:
-
摘要:
血管内皮生长因子(VEGF)可刺激血管内皮细胞分裂、增殖,增加血管通透性,在糖尿病肾病(DN)中主要引起炎性反应,促进蛋白尿的形成。单核细胞趋化蛋白-1(MCP-1)主要趋化单核细胞和T淋巴细胞,使各种炎性细胞尤其是单核细胞向病变部位聚集。在DN中MCP-1除引起肾进行性损伤外,还促进肾的纤维化。结缔组织生长因子(CTGF)是致纤维化因子,可促进肾的纤维化和蛋白尿的形成。
Abstract:
-

参考文献/References:

[1] Hyder S,Murthy L,Stancel G.Progestin regulation of vascular endothelial growth factor in human breast cancer cells [J].Cancer Res,1998,58(2):392-395.
[2] Tzouveleki MM,Tsartsalis S,Tomos C.Vascular endothelial growth factors(VEGF)in the pathogenesis of diabetic nephropathy of type 1 diabetes mellitus [J].Curr Drug Targets,2011,12(1):107-114.
[3] Wu FT,Stefanini MO,Mac Gabhann F,et al.A systems biology perspective on sVEGFR1: its biological function,pathogenic role and therapeutic use [J].J Cell Mol Med,2010,14(3):528- 652.
[4] Feliers D,Duraisamy S,Barnes JL,et al.Translational regulation of vascular endothelial growth factor expression in renal epithelial cells by angiotensinⅡ [J].Am J Physiol Renal Physiol,2005,288(3):F521-F529.
[5] 周青,王冬芽,郭兵,等.糖尿病大鼠肾组织VEGF和TGF-β1的动态表达及意义[J].江西医药,2008,43(1):13-16.
[6] Baelde HJ,Eikmans M,Lappin DW,et al.Reduction of VEGF-A and CTGF expression in diabetic nephropathy is associated with podocyte loss [J].Kidney Int,2007,71(7):637-645.
[7] Tesch HG.MCP-1/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy [J].Am J Physiol Renal Physiol,2008,294(4): F697-F701.
[8] Biswas SK,Sodhi A,Paul S,et al.Regulation of nitric oxide production by murine peritoneal macrophages treated in vitro with chemokine monocyte chemoattractant protein 1 [J].Nitric Oxide,2001,5(6):566-579.
[9] Cheng J,Diaz Encarnacion MM,Warner GM,et al.TGF-beta1 stimulates monocyte chemoattractant protein-1 expression in mesangial cells through a phosphodiesterase isoenzyme 4-dependent process [J].Am J Physiol Cell Physiol,2005,289(4):C959-C970.
[10] Ito Y,Aten J,Bende RJ,et al.Expression of connective tissue growth factor in human renal fibrosis [J].Kidney Int,1998,53(4):853-861.
[11] Burns WC,Twigg SM,Forbes JM,et al.Connective tissue growthfactor plays an important role in advanced glycation end productinduced tubular to-mesenchymal transition: implications fordiabetic renal dis epithelial-ease [J].J Am Soc Nephrol,2006,17(9):2484-2494.

备注/Memo

备注/Memo:
作者简介:孙丽娜,硕士,副主任检验师,主要从事糖尿病及并发症的研究工作 通讯作者:孙丽娜,E-mail:sunlinapj@126.com
更新日期/Last Update: 2014-07-08