|本期目录/Table of Contents|

[1]王建中,吴木松,姚德镇.依达拉奉联合前列地尔辅助治疗不稳定性心绞痛的可行性分析[J].慢性病学杂志,2018,(03):273-276.
　WANGJian-zhong,WUMu-song,YAODe-zhen.Feasibility analysis of edaravin combined with alprostadil in the treatment of unstable angina pectoris[J].,2018,(03):273-276.
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依达拉奉联合前列地尔辅助治疗不稳定性心绞痛的可行性分析(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2018年03期
页码:
273-276
栏目:
论著
出版日期:
2018-03-28

文章信息/Info

Title:
Feasibility analysis of edaravin combined with alprostadil in the treatment of unstable angina pectoris
作者:
王建中; 吴木松; 姚德镇
广东省汕尾中医医院内科，广东 汕尾 516600
Author(s):
WANGJian-zhong; WUMu-song; YAODe-zhen
InternalMedicineDepartment,ShanweiTraditional Chinese MedicineHospital,Guangdong516600,China Correspondingauthor:WANGJian-zhong,E-mail:wangjz@163.com
关键词:
不稳定型心绞痛; 依达拉奉; 前列地尔; 氧自由基
Keywords:
Unstable angina pectoris;  Edaravone;  Alprostadil;  Oxygen radical
分类号:
R541
DOI:
-
摘要:
目的 不稳定性心绞痛具有独特的病理机制及临床预后，如不及时治疗，很可能会进展成为急性心肌梗 死。本研究探讨依达拉奉辅助治疗不稳定性心绞痛的有效性和安全性。方法 选取2015年6月—2017年2月广 东省汕尾中医医院心内科收治的60例不稳定型心绞痛患者，采用随机数字表法分为观察组和对照组，每组 30例。入院后给予静卧休息、吸氧及口服阿司匹林、硝酸异山梨酯、他汀类调脂药物等常规治疗，其中对照组在 常规治疗的基础上采用前列地尔治疗，观察组在对照组的治疗基础上联合依达拉奉治疗。两组患者治疗2周后， 评价临床疗效、心绞痛发作频率、最长持续时间，心电图缺血指标改善及不良反应发生率。结果 两组患者治 疗总有效率分别为90.00%和76.67%，观察组显著高于对照组，差异有统计学意义（P<0.05）。两组患者治疗后 心绞痛发作频率分别为（2.43±0.71）次和（3.96±0.93）次；最长持续时间分别为（3.18±1.37）min和（4.94± 1.55）min，观察组显著低于对照组，差异均有统计学意义（P<0.05）。两组患者心电图缺血改善患者比例分别为 93.33%和76.67%，观察组改善显著高于对照组，差异有统计学意义（P<0.05）。两组患者不良反应发生率分别为 23.33%和26.67%，差异无统计学意义（P>0.05）。结论 前列地尔联合依达拉奉治疗不稳定性心绞痛临床疗效 确切，能够显著提升治疗有效率，降低心绞痛发作频率及持续时间，促进心电图缺血指标改善且未增加不良反应 发生率。
Abstract:
Objective Unstable angina pectoris has specific pathomechanism and prognosis, and it will be progressed into acute myocardial infarction if it is not timely treated. This subject was to investigate the efficacy and safety of edaravin in the treatment of unstable angina pectoris. Methods Totally60 cases of unstable angina patients treated in Internal Medicine Department, Shanwei Traditional Chinese Medicine Hospital from June2015 to February 2017 were divided into observation group and control group by random number table method, 30 cases in each group. All subjects received routine treatment such as repose rest, oxygen uptake, and oral aspirin, isosorbide dinitrate, lipid statin drugs, etc. On the basis of the above-mentioned treatment, the control group received alprostadil, and observation group received edaravin and alprostadil. After two weeks of treatment, clinical efficacy was evaluated, and these indexes such as angina attack frequency, maximum duration, electrocardiogram ischemia index and adverse reaction rate were observed. Results The total clinical effect rate in the control group and observation group was 90.00%,76.67%, respectively, which was significantly higher in the obser-vation group than in the control group（P<0.05）. The angina frequency in the control group and ob-servation group was（2.43±0.71）times,（3.96±0.93）times, respectively, and the longest duration was （3.18±1.37）min,（4.94±1.55）min，respectively, which were significantly lower in the observation group than in the control group（P<0.05）. Ischemia ECG index improved rate in the observation group and the control group was 93.33% and76.67%, respectively, which was significantly higher in the observation group than in the control group（P<0.05）. The adverse reactions rate in the observa-tion group and the control group was 23.33% and26.67%, and there was no significant difference be-tween the two groups（P>0.05）. Conclusion Edaravin combined with alprostadil has the exact clini-cal curative effect in treatment of unstable angina pectoris, and it can significantly enhance treatment ef-ficiency, reduce angina frequency and duration, improve ischemia ECG indexes, but did not increase the incidence of adverse reactions.

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备注/Memo

备注/Memo:
作者简介：王建中，大学本科，主治医师，研究方向：心血管内科 通信作者：王建中，E-mail：wangjz@163.com
更新日期/Last Update: 2018-03-28