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[1]邱萍,静艳,文萍,等.氟哌噻吨美利曲辛治疗非糜烂性反流性食管病的临床疗效观察[J].慢性病学杂志,2018,(03):248-250.
　QIUPing *,JINGYan,WENPing,et al.Clinical effect of flupentixol and melitracen tablets on non-erosive reflux disease[J].,2018,(03):248-250.
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氟哌噻吨美利曲辛治疗非糜烂性反流性食管病的临床疗效观察(PDF)

《慢性病学杂志》[ISSN:1674-8166/CN:11-5900/R]

卷:
期数:
2018年03期
页码:
248-250
栏目:
论著
出版日期:
2018-03-28

文章信息/Info

Title:
Clinical effect of flupentixol and melitracen tablets on non-erosive reflux disease
作者:
邱萍1; 静艳2; 文萍1; 王桂良1; 文剑波1
萍乡市人民医院（1.消化内科；2.药剂科），江西 萍乡 337000
Author(s):
QIUPing * ; JINGYan; WENPing; WANGGui-liang; WENJian-bo
*Departmentof Gastroenterology, People’sHospitalofPingxiang,Pingxiang,Jiangxi337000,China Correspondingauthor:QIUPing,E-mail:992168117@qq.com
关键词:
非糜烂性反流性食管病; 焦虑; 抑郁; 氟哌噻吨美利曲辛片
Keywords:
Non-erosive reflux disease;  Anxiety;  Depressant;  Flupentixol and melitracen tablets
分类号:
R571
DOI:
-
摘要:
目的 探讨常规治疗联合氟哌噻吨美利曲辛对非糜烂性反流性食管病（NERD）患者的临床疗效，为临 床用药提供依据。方法 选取2014年6月至2017年6月被初次诊断为NERD的患者80例作为研究对象，采用汉 密尔顿焦虑量表（HAMA）和汉密尔顿抑郁量表（HAMD）进行焦虑、抑郁程度评分，采用反流性疾病问卷 （RDQ）量表进行症状评分。对照组38例患者给予常规剂量抗酸药和莫沙必利进行治疗，观察组42例患者在对照 组的基础上加用氟哌噻吨美利曲辛（黛力新），疗程均为8周。治疗4周和8周后再次评价两组焦虑、抑郁、 NERD症状，并观察不良反应。结果 80例NERD患者中有58例伴有焦虑或抑郁。治疗4周和8周时，观察组 RDQ评分均低于对照组，差异有统计学意义（P<0.05）；治疗4周和8周后，观察组的HAMA评分和HAMD评 分均低于对照组，差异有统计学意义（P<0.05）。两组均未发现严重不良反应。结论 NERD患者并发焦虑抑 郁的比例高，常规治疗基础上联合氟哌噻吨美利曲辛对NERD患者疗效显著。
Abstract:
Objective To study the clinical effect of conventional treatment combined with flupentixol and melitracen tablets in non-erosive reflux disease（NERD）patients. Methods Totally80 patients during June 2014 to June 2017 who were first diagnosed NERD were selected as the research sub-jects, and they were divided into two groups.The control group （n=38）was treated with routine dose of antiacids and mosapride;the observation group（n=42）was treated with flupentixol and melitracen tablets （Deanxit）on the basis of the control group. All patients were treated for 8 weeks. Before treatment, 4 weeks and8 weeks after treatment, degrees of anxiety and depression in the two groups were evaluated by using the Hamilton Anxiety Scale（HAMA）and Hamilton Depression Scale （HAMD）, and their symptom scores were evaluated by using the reflux disease questionnaire（RDQ） scale. Adverse reactions after treatment in the two groups were observed. Results There were58 pa-tients with anxiety or depressionamong the 80 NERD patients. After4 weeks and8 weeks treatment, RDQ scoresin the observation group were lower than those in the control group, the differences were statistically significant（P<0.05）; HAMA scores and HAMD scoresin the observation group were low-er than those in the control group, the differences were statistically significant（P<0.05）. No serious complications were found in the two groups.Conclusion NERD patients have high incidence rate of anxiety and depression. The conventional treatment combined withflupentixol and melitracen tablets havesignificantly curative effect on patients with NERD.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介：邱萍，大学本科，主治医师，研究方向：胃食管相关疾病的诊治 通信作者：邱萍，E-mail:992168117@qq.com
更新日期/Last Update: 2018-03-28